Vitamin D insufficiency, hemoglobin, and anemia in children with chronic kidney disease

Altemose, Kathleen E.; Kumar, Juhi; Portale, Anthony A.; Warady, Bradley A.; Furth, Susan L.; Fadrowski, Jeffrey J.; Atkinson, Meredith A.

doi:10.1007/s00467-018-4020-5

Cited by 17 publications

(7 citation statements)

References 29 publications

(33 reference statements)

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“…Larson et al [ 20 ] found that vitamin A could directly reflect the degree of anemia in preschool and school-age children as an independent factor through investigation. In addition, Altemose et al [ 21 ] showed that vitamin D deficiency also increased the risk of iron deficiency anemia in children. These studies indicate that increased vitamins A and D can help improve the symptoms of anemia in children.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Changes of Serum Ferritin, Hemoglobin, and Serum Iron (SI) and Treatment Effect of Iron Proteinsuccinylate Oral Solution Combined with Vitamin A and D Drops on Children with Nutritional Iron Deficiency Anemia

Yan-bo

Zhang

et al. 2022

BioMed Research International

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Objective. The purpose was to evaluate the treatment effect of iron proteinsuccinylate oral solution combined with vitamin A and D drops on children with nutritional iron deficiency anemia. Methods. 124 children treated in the outpatient department of our hospital from January 2017 to January 2020 were selected as the study subjects. They were randomly divided into control and observation two groups. The control group was treated with iron proteinsuccinylate oral solution (1.5 mL/kg) in the morning and evening, respectively. The observation group received adjuvant treatment with oral vitamin A and D drops based on the treatment of the control group. The treatment effect of proteinsuccinylate oral solution combined with vitamin A and D drops was evaluated by the serum iron (SI), serum ferritin (SF), and transferrin (TRF) levels, the values of CD3+, CD4+, and CD4+/CD8+, and other evaluation indicators. Results. After treatment, the SI and SF levels of children in both groups significantly increased ( P < 0.01 ) while the TRF level significantly decreased ( P < 0.01 ), and the SI and SF levels in the observation group increased more significantly, and the TRF level decreased more significantly compared with those in the control group ( P < 0.01 ). After treatment, the values of CD3+, CD4+, and CD4+/CD8+ of children in both groups significantly increased compared with those before treatment ( P < 0.01 ), and the values of CD3+, CD4+, and CD4+/CD8+ increased more significantly in the observation group compared with those in the control group ( P < 0.01 ). In addition, the evaluation results of treatment effect showed that the markedly effective rate in the observation group was significantly higher than that in the control group ( P < 0.01 ). Conclusion. Iron proteinsuccinylate oral solution combined with vitamin A and D drops can better improve the anemia symptoms in children, with high application value.

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Section: Discussionmentioning

confidence: 99%

[Retracted] Changes of Serum Ferritin, Hemoglobin, and Serum Iron (SI) and Treatment Effect of Iron Proteinsuccinylate Oral Solution Combined with Vitamin A and D Drops on Children with Nutritional Iron Deficiency Anemia

Yan-bo

Zhang

et al. 2022

BioMed Research International

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“…In several studies vitamin D has been reported to have a direct stimulatory effect on erythroid precursor cells in CKD patients. The burst-forming unit-erythroid (BFU-E) analyze exposed that combined decrease doses of erythropoietin and vitamin D significantly increased proliferation of mononuclear cells isolated from the peripheral blood of patients with CKD compared to low-dose erythropoietin alone (Altemose et al;. Furthermore, high-dose vitamin D increased BFU-E proliferation, but this was not detected in cells obtained from healthy people.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency as risk factor associated with anemia and outcome hemodialysis patients

Ulrahman

Sharba

2022

ijhs

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Background: Vitamin D deficiency and anemia are common problems that increased pathophysiology in the chronic kidney disease (CKD) undergoing hemodialysis (HD). This study was conducted to assess the association between vitamin D and anemia status in HD patients. Methods: This was a cross-sectional study of 65 HD patients and EPO therapy were enrolled; compared with 25 age matched healthy individuals as controls. The current study was investigated serum hepcidin, iron status was included serum ferritin and iron levels, anemia hematological indices such as RBC, Hb, MCV, and MCH, in addition to other clinical parameters of kidney function, and C-reactive protein (CRP) as inflammation markers were performed in both HD patients and controls. Results: The mean patient age was (45.65±13.34) years, with dialysis vintage of median (IQR) was (12 (3-36) month. serum hepcidin were highly significantly increase in HD patients than in the control group (622.3±139.6, and 465.16±80.31pg/ml, respectively p = 0.0001). serum hepcidin significantly associated with 37% anemia severity about (692.4±119.8) pg/ml more than patient with 49.2% of moderate about (605.3±117.7) pg/ml, (p=0.007) as compared with 13.8% of mild anemia groups (531.8±99.12) pg/ml, (p=0.001).

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“…Other important parameters could not be analyzed, such as hepcidin and ferritin. Hepcidin, in particular, as a master regulator for iron absorption, has been shown to distinguish iron deficiency anemia and anemia of inflammation [37,38], with the latter type of anemia possibly benefiting more from vitamin D correction than the former [39,40].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation Modestly Reduces Serum Iron Indices of Healthy Arab Adolescents

et al. 2018

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Vitamin D deficiency has been shown to affect iron status via decreased calcitriol production, translating to decreased erythropoiesis. The present study aimed to determine for the first time whether vitamin D supplementation can affect iron levels among Arab adolescents. A total of 125 out of the initial 200 Saudi adolescents with vitamin D deficiency (serum 25(OH)D < 50 nmol/L) were selected from the Vitamin D-School Project of King Saud University in Riyadh, Saudi Arabia. Cluster randomization was done in schools, and students received either vitamin D tablets (1000 IU/day) (N = 53, mean age 14.1 ± 1.0 years) or vitamin D-fortified milk (40IU/200mL) (N = 72, mean age 14.8 ± 1.4 years). Both groups received nutritional counseling. Anthropometrics, glucose, lipids, iron indices, and 25(OH)D were measured at baseline and after six months. Within group analysis showed that post-intervention, serum 25(OH)D significantly increased by as much as 50%, and a parallel decrease of −42% (p-values <0.001 and 0.002, respectively) was observed in serum iron in the tablet group. These changes were not observed in the control group. Between-group analysis showed a clinically significant increase in serum 25(OH)D (p = 0.001) and decrease in iron (p < 0.001) in the tablet group. The present findings suggest a possible inhibitory role of vitamin D supplementation in the iron indices of healthy adolescents whose 25(OH)D levels are sub-optimal but not severely deficient, implying that the causal relationship between both micronutrients may be dependent on the severity of deficiency, type of iron disorder, and other vascular conditions that are known to affect hematologic indices. Well-designed, randomized trials are needed to confirm the present findings.

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Vitamin D insufficiency, hemoglobin, and anemia in children with chronic kidney disease

Abstract: The data support our hypothesis that vitamin D insufficiency/deficiency increases the odds of anemia in children with CKD. The effect was strong and significant among white, but not black, children.

Cited by 17 publications

References 29 publications

[Retracted] Changes of Serum Ferritin, Hemoglobin, and Serum Iron (SI) and Treatment Effect of Iron Proteinsuccinylate Oral Solution Combined with Vitamin A and D Drops on Children with Nutritional Iron Deficiency Anemia

[Retracted] Changes of Serum Ferritin, Hemoglobin, and Serum Iron (SI) and Treatment Effect of Iron Proteinsuccinylate Oral Solution Combined with Vitamin A and D Drops on Children with Nutritional Iron Deficiency Anemia

Vitamin D deficiency as risk factor associated with anemia and outcome hemodialysis patients

Vitamin D Supplementation Modestly Reduces Serum Iron Indices of Healthy Arab Adolescents

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