Vitamin D insufficiency is associated with increased risk of first-trimester miscarriage in the Odense Child Cohort

Andersen, Louise Bjørkholt; Jørgensen, Jan Stener; Jensen, Tina Kold; Dalgård, Christine; Barington, Torben; Nielsen, Jan; Beck-Nielsen, Signe Sparre; Husby, Steffen; Abrahamsen, Bo; Lamont, Ronald F.; Christesen, Henrik Thybo

doi:10.3945/ajcn.114.103655

Cited by 90 publications

(71 citation statements)

References 41 publications

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“…This corresponds with the findings from previous largescale studies on 25(OH)D concentrations in pregnant women in Nordic countries. The Norwegian Mother and Child Cohort Study found a 25(OH)D mean level of 74 nmol/l in midpregnancy [30] whereas the Danish Odense Child Cohort study revealed a median mid-pregnancy level of 66 nmol/l [31]. The use of cod-liver oil by pregnant women in Norway [32] could potentially contribute to the observed relatively higher 25(OH)D levels.…”

Section: Discussionmentioning

confidence: 91%

Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies

et al. 2016

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Aims/hypothesis The aim of this work was to assess whether neonatal levels of 25-hydroxyvitamin D (25(OH)D) are associated with risk of developing type 1 diabetes before the age of 18 years. Methods Two large-scale studies with different designs-a case-cohort and a case-control-were conducted using Danish national register data and biobank material. Weighted Cox regression and conditional logistic regression were used to calculate HRs and ORs, respectively. The concentration of 25(OH)D was assessed from neonatal dried blood spots using highly sensitive liquid chromatography-tandem mass spectrometry. Quintiles of 25(OH)D 3 were used in the main analyses.Results The case-cohort study included 912 type 1 diabetes cases and 2866 individuals without type 1 diabetes born in Denmark between 1981 and 2002 and followed up until the end of 2012. The case-control study included 527 matched case-control pairs born between 1981 and 1999 and followed up until May 2004. Both studies found no association between 25(OH)D 3 levels and later risk of developing type 1 diabetes. The neonatal total 25(OH)D levels in the studies were low: 46% (case-cohort study) and 51% (case-control study) of individuals had 25(OH)D levels <25 nmol/l. Conclusions/interpretation Our two large-scale national studies showed that 25(OH)D 3 levels around the time of birth were not associated with later type 1 diabetes risk. Whether higher levels of 25(OH)D 3 during pregnancy, acquired by higher doses of supplementation than are recommended today in Ramune Jacobsen and Steffen U. Thorsen are joint first authors.Electronic supplementary material The online version of this article

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Section: Discussionmentioning

confidence: 91%

Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies

et al. 2016

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“…Zhang et al (2017) in a systematic review and meta-analysis, which included 5 cohort studies, [55][56][57][58][59] concluded that an extremely low 25(OH)D level (<20 ng/mL) was significantly associated with an increased risk of SA in the first trimester. Zhang et al (2017) in a systematic review and meta-analysis, which included 5 cohort studies, [55][56][57][58][59] concluded that an extremely low 25(OH)D level (<20 ng/mL) was significantly associated with an increased risk of SA in the first trimester.…”

Section: Introductionmentioning

confidence: 99%

Recurrent pregnancy loss and vitamin D: A review of the literature

Gonçalves

Braga

et al. 2018

American J Rep Immunol

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Recurrent pregnancy loss (RPL) affects approximately 1%-2% of reproductive women. Auto- and cellular immune responses seem to be associated with RPL. Vitamin D (VD) has been shown to play a role in the modulation of the immune system. Effects of VD deficiency (VDD) in pregnancy have been associated with preeclampsia, gestational diabetes, fetal growth restriction, preterm labor, and sporadic spontaneous abortion (SA). We systematically reviewed articles that studied women with 2 or more SA and its association with VD. Eleven studies were included. Studies reported a high prevalence of VD insufficiency (VDI) or VDD in women with RPL and suggested that this could be associated with immunological dysregulation and consequently with RPL. Immunological benefits were reported in the peripheral blood of women with RPL after VD exposure. Thus, it is possible to speculate a beneficial role for VD supplementation in RPL. It seems that there are not differences in the vitamin D receptor (VDR) and CYP27B1 expression in endometrium of women with RPL but, in villous and decidual tissues, RPL women seem to have a decreased expression of VDR and, perhaps, a decreased expression of CYP27B1. Further randomized controlled studies are required to investigate the association between VDD or VDI and RPL.

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“…Two authors (ZH and XJ) independently extracted original data from the selected papers using the developed data abstraction form, and a third author (LX) made a decision when disagreements occurred. Because data for two cohort studies were inaccessible, we tried to contact the authors of these studies via email to acquire the data for calculating the RRs. Andersen et al .…”

Section: Methodsmentioning

confidence: 99%

Meta‐analysis of the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss

Zhang

Huang

Xiao

et al. 2017

Intl J Gynecology & Obste

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Vitamin D insufficiency is associated with increased risk of first-trimester miscarriage in the Odense Child Cohort

Cited by 90 publications

References 41 publications

Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies

Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies

Recurrent pregnancy loss and vitamin D: A review of the literature

Meta‐analysis of the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss

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