Vitamin D Insufficiency

Thacher, Tom D.; Clarke, B.L.

doi:10.4065/mcp.2010.0567

Cited by 681 publications

(576 citation statements)

References 88 publications

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“…Vitamin D deficiency was defined as serum concentration <20 ng/ml based on modified Holick's classification (Thacher and Clarke 2011), while Creactive protein levels in excess of 5 mg/l were considered elevated.…”

Section: Laboratory Investigationsmentioning

confidence: 99%

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Tay

Ding

Leung

et al. 2015

AGE

140

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With considerable variation including potential sex-specific differential rate of skeletal muscle loss, identifying modifiable factors for sarcopenia will be pivotal to guide targeted interventions. This study seeks to identify clinical and biological correlates of sarcopenia in community-dwelling older adults, with emphasis on the role of anabolic and catabolic stimuli, and special reference to gender specificity. In this crosssectional study involving 200 community-dwelling and functionally independent older adults aged ≥50 years, sarcopenia was defined using the Asian Working Group for Sarcopenia criteria. Comorbidities, cognitive and functional performance, physical activity and nutritional status were routinely assessed. Biochemical parameters included haematological indices, lipid panel, vitamin D level, anabolic hormones [insulin-like growth factor-1 (IGF-1), free testosterone (males only)] and catabolic markers [inflammatory markers (interleukin-6, Creactive protein) and myostatin]. Multiple logistic regression was performed to identify independent predictors for sarcopenia. Age was associated with sarcopenia in both genders. Malnutrition conferred significantly higher odds for sarcopenia in women (OR=5.71, 95 % CI 1.13-28.84.44, p=0.035) while higher but acceptable range serum triglyceride was protective in men (OR=0.05, 95 % CI 0.00-0.52, p=0.012). Higher serum myostatin independently associated with higher odds for sarcopenia in men (OR=1.11, 95 % CI 1.00-1.24, p=0.041). Serum IGF-1 was significantly lower amongst female sarcopenic subjects, with demonstrable trend for protective effect against sarcopenia in multiple regression models, such that each 1 ng/ml increase in IGF-1 was associated with 1 % decline in odds of sarcopenia in women (p=0.095). Our findings support differential pathophysiological mechanisms for sarcopenia that, if corroborated, may have clinical utility in guiding sex-specific targeted interventions for community-dwelling older adults.

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Section: Laboratory Investigationsmentioning

confidence: 99%

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Tay

Ding

Leung

et al. 2015

AGE

140

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“…Its deficiency is related to rickets in children, osteomalacia and other forms of skeletal diseases in adults. Growing body of evidence relates VDD with cardiovascular disease, some types of cancers, diabetes and mental illnesses [7]. Body can synthesize vitamin D in the skin when exposed to UV-β radiation.…”

Section: Introductionmentioning

confidence: 99%

Assessment of vitamin D intake among Libyan women – adaptation and validation of specific food frequency questionnaire

Faid

Nikolić

Milešević

et al. 2018

Libyan Journal of Medicine

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Vitamin D deficiency (VDD) has pandemic proportions worldwide. Numerous studies report on high prevalence of VDD in sunny regions like Near East and North Africa (NENA). Previous studies indicated that Libyan population was at risk of VDD. To contribute to the body of evidence, measurement of vitamin D status on children, adults, in Misurata region was conducted, and confirmed with validated dietary intake study. Serum 25(OH)D was analysed using electrochemiluminescence protein binding assay. Existing Food Frequency Questionnaires (FFQ) were adapted to Libyan Women Food Frequency Questionnaire (LW-FFQ). Repeated 24 h dietary recalls and LW-FFQ were employed in vitamin D intake evaluation. LW-FFQ was validated using 24 h dietary recall and vitamin D status as referent methods. The questionnaires included anthropometry and lifestyle information. Vitamin D status assessment revealed inadequate levels (25(OH)D < 50 nmol/l) in almost 80% of participants. Women (25-64 y) were identified as the most vulnerable group with vitamin D inadequacy present in 82% (61.6% had 25(OH)D < 25 nmol/l, and 20.2% had 25–50 nmol/l 25(OH)D). Average Vitamin D intake within the study sample (n = 316) was 3.9 ± 7.9 µg/d, with 92% participants below both Institute of Medicine (IOM) (10 µg/d) and European Food Safety Authority (15 µg/d) recommendations. Measured vitamin D status, in 13% of this group, correlated significantly (p = 0.015) with intake estimates. Based on self-report, consumption of vitamin D supplements does not exist among study participants. Additional lifestyle factors influencing vitamin D status were analysed. Only 2% of study participants spend approximately 11 min on the sun daily, 60.4% were obese, 23.1% were overweight and 71.2% reported low physical activity. These findings confirm previous reports on high prevalence of VDD in women across NENA, and in Libya. The situation calls for multi-sectoral actions and public health initiatives to address dietary and lifestyle habits.

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“…Vitamin D is a prohormone with a key role in the maintenance of both skeletal, and as is increasingly recognized, nonskeletal health [1]. Vitamin D 3 (cholecalciferol) can be obtained in the diet from animal sources or supplementation, or be produced in the skin via exposure to ultraviolet B radiation from sunlight.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D insufficiency in myeloproliferative neoplasms and myelodysplastic syndromes: Clinical correlates and prognostic studies

et al. 2011

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Vitamin D insufficiency is commonly observed in the general population; observational studies have suggested an association with increased risk of cancer development. We examined the clinical and prognostic relevance of low plasma levels of 25-hydroxyvitamin D (25[OH]D) in myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS). A total of 409 patients were studied: 247 (60%) with primary myelofibrosis (PMF), 74 (18%) with de novo MDS, 63 (15%) with polycythemia vera (PV), and 25 (6%) with essential thrombocythemia (ET). Plasma 25(OH)D levels were measured by liquid chromatography-tandem mass spectrometry; a level lower than 25 ng/mL indicated vitamin D insufficiency and a level lower than 10 ng/mL indicated severe deficiency. The proportion of patients with 25(OH)D insufficiency was significantly greater in PMF (48%) and PV (43%) when compared with ET (28%) and MDS (28%) (P 5 0.01). Severe 25(OH)D deficiency was significantly more frequent in ET (12%) and PMF (9%), compared with PV (3%) and MDS (1%) (P 5 0.05). There were no significant correlations between 25(OH)D insufficiency, or severe deficiency, and a variety of clinical or laboratory variables in PMF, MDS, or PV. Furthermore, Vitamin D insufficiency did not influence either overall or leukemia-free survival in PMF, MDS, or PV (P > 0.05). We conclude that while hypovitaminosis D is relatively common in MPN and MDS, its clinical relevance for prognosis is limited. Although the roles of vitamin D in calcium and bone homeostasis is well established, recent data point to a broader pleiotropic role in nonskeletal tissues with effects on cell proliferation, differentiation, and apoptosis. Vitamin D receptors and the 1a-hydroxylase enzyme necessary for conversion of 25(OH)D to 1,25(OH) 2 D have been detected in multiple tissues; there, 25(OH)D may be converted to the biologically active metabolite and exert paracrine effects in local tissues without affecting serum vitamin D levels.While several observational studies have suggested an association between lower 25(OH)D levels and certain tumors [3,4], this association is not universal (i.e., does not apply to all tumor types) [5,6] and such preliminary obser-

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Vitamin D Insufficiency

Cited by 681 publications

References 88 publications

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Assessment of vitamin D intake among Libyan women – adaptation and validation of specific food frequency questionnaire

Vitamin D insufficiency in myeloproliferative neoplasms and myelodysplastic syndromes: Clinical correlates and prognostic studies

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