Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review

Abstract

Vitamin D is known to increase Ca absorption in adults. However, the threshold vitamin D status to benefit Ca absorption is lower than the target vitamin D status for higher bone mineral density and lower fracture risk, pointing to another pathway for vitamin D to benefit bone. One possibility is by affecting osteoblast and osteoclasts directly. Vitamin D-related bone metabolism may also be affected by soy isoflavones, which selectively bind to the estrogen receptor β and may reduce bone loss in postmenopausal women. We discuss a possible synergistic effect of soy isoflavones and vitamin D on bone by affecting osteoblast and osteoclast formation and activity in postmenopausal women.

Niveau de connaissance et composition minérale de Hydrocotyle bonariensis Lam. (Araliaceae), une plante utilisée dans les ménages du District d’Abidjan (Côte d’Ivoire)

“…Chacun de ces micronutriments joue un rôle important dans le métabolisme de l'organisme. Le calcium a un effet sur la santé des os en termes de protection (Park et Weaver, 2012) ; le magnésium peut faire baisser la tension artérielle, le taux du cholestérol et est impliqué dans les systèmes de défenses naturelles contre les agressions de toute sorte ; il est très important pour la femme enceinte (Sidor et al, 2016). Le fer a un rôle essentiel dans le métabolisme des globules rouges (hémoglobine), dans la fonction musculaire.…”

Modulatory effects of l-arginine and soy enriched diet on bone homeostasis abnormalities in streptozotocin-induced diabetic rats

“…Soy also increases ERb expression that lead to an increase in the expression of vitamin D (VD) receptor and VD metabolites in osteoblastic cells, so soy and VD can synergistically stimulate bone formation [66]. Regarding bone resorption, soy enriched diet decreased serum cathepsin k level and downregulated the expression of bone cathepsin k mRNA in diabetic rats due to inhibition of the tyrosine-specific protein kinase activity of the epidermal growth factor (EGF) receptor on osteoclasts cells that results in decreased osteoclastic protein synthesis [67].…”

The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism

“…In vitro studies have shown that isoflavones increase vitamin D receptor expression on the cell surface and, thus, could potentiate the action of vitamin D [24]. Furthermore, it has been found that isoflavones can inhibit the CYP24 enzyme, which is involved in the degradation of 1,25-dihydroxycholecalciferol and its precursor 25-hydroxycholecalciferol, which would increase plasma levels [10].…”