Vitamin D intoxication: a cause of hypocalcaemia and acute renal failure in a HIV patient

Abstract

Hypercalcaemia in patients with HIV infection is usually associated with specific conditions such as lymphoma and granulomatous diseases. We described a case of severe hypercalcaemia consequent to vitamin D intoxication and secondary renal failure in a HIV patient under tenofovir using. Serum creatinine and calcium returned to near normal levels after vitamin D discontinuation, saline and furosemide administration. Some aspects of the drug-induced nephropathy are discussed.

Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review

“…Massive use of vitamin D with consequent development of AKI and association with hyperparathyroidism has been described. Tuon et al [26] described the case of an HIV patient with severe hypercalcemia consequent to vitamin D intoxication and secondary renal failure associated with tenofovir. Serum creatinine and calcium returned to near normal levels after vitamin D discontinuation, saline infusion and furosemide administration.…”

Necrosis tubular aguda por hipercalcemia secundaria a intoxicación por vitamina D

“…Se sugiere que la toxicidad por vitamina D se presenta sólo cuando su administración es superior a 10.000 UI/día, aunque la mayoría de los reportes informan dosis que van entre 100.000 a 600.000 UI por día (19)(20)(21)(22).…”

Nephrocalcinosis associated with the use of anabolic steroid

“…21 Outros casos de IRA e hipercalcemia estiveram associados à suplementação de cálcio e/ou excesso de vitaminas A e D e, em alguns desses, a biópsia demonstrou nefrocalcinose. [21][22][23][24][25][26] tornando-se problema de saúde pública. No Brasil, estudos quantitativos realizados em academias de musculação de São Paulo, Porto Alegre e Goiânia encontraram altas prevalências do uso de anabolizantes (respectivamente, 19%; 11,1% e 9%), alertando para o problema.…”