Vitamin D intoxication presenting as acute renal failure

Naik, Muzafar; Banday, K A; Najar, M Saleem; Reshi, A R; Bhat, Mohd Ashraf

doi:10.4103/0971-4065.43693

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…Significant injury after vitamin D intoxication has been reported in individual cases and in small case series from manufacturing errors, dosing errors, and misuse of OTC vitamin D supplementation. [4][5][6][7][8][9][10][11][12][13] Severe clinical effects after vitamin D intoxication have occurred in children and adults, and have included confusion, seizures, coma, renal failure, cardiac arrhythmias, and psychiatric disturbances. Severe events appear to be uncommon however, despite the massive increase in the use of vitamin D both by prescription and as a widely available OTC vitamin supplement.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D exposures reported to US poison centers 2000–2014

et al. 2015

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There has been an increased use of vitamin D both by prescription and by the public as a widely available supplement. We evaluated 15 years of single-substance vitamin D exposures to US poison centers. Methods: Retrospective analysis of data from the National Poison Data System (NPDS) to evaluate clinical effects, trends, and outcomes of exposures to vitamin D over the period January 1, 2000 through June 30, 2014. Cases were limited to exposures involving vitamin D as a single substance. Multiple vitamin products that may have included vitamin D were not included in this study. Results: From 2000 through June 30, 2014, there were 25,397 human exposures to vitamin D reported to NPDS. There was a mean of 196 cases per year from 2000 to 2005, followed by a 1600% increase in exposures between 2005 and 2011 to a new annual mean of 4535 exposures per year. The mean and median ages were 23.4 years and 10 years, respectively. There were no fatalities, but five (0.02%) major effect outcomes. Serious medical outcomes (major or moderate outcome) were infrequent, ranging from 2 patients/year to 22 patients/year. Clinical effects were primarily gastrointestinal (0.7–1.5%) and mild neurological effects (0.2–0.4%). There was a decline in the percentage of patients treated in a health care facility and of patients with serious medical outcome. Conclusion: Despite the enormous increase in number of exposures, there was not a significant increase in patients with a serious medical outcome. Rare severe outcomes may occur.

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Section: Discussionmentioning

confidence: 99%

Vitamin D exposures reported to US poison centers 2000–2014

et al. 2015

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“…In studies determining vitamin D safety and efficacy, considering hypercalcemia as a critical effect, the adverse effect occurring at the lowest intake, there were no increases in mean calcium levels with higher vitamin D intakes tested in controlled trials up to 100,000 IU per day (8). Common circumstances of vitamin D intoxication are wrong formulations, prescriptions, self medications, increasing use of activated vitamin D formulations for replacement and inadvertent high doses of vitamin D for musculoskeletal and joint problems (9)(10)(11)(12)(13). Factors predisposing an individual to vitamin D toxicity include elderly, increased calcium intake, parenteral vitamin D therapy, decreased renal function, diminished estrogen levels, presence of granulomatous diseases (14).…”

Section: Discussionmentioning

confidence: 99%

An unusual case of hypercalcemia in a patient of concomitant hypoparathyroidism and celiac disease

Somani

Kotwal

Upreti

2016

ccmbm

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SummaryMilk alkali syndrome has shown resurgence with increase in use of (prescription or non prescription) calcium supplements. Cases of iatrogenic vitamin D intoxication has also increased due to increasing use of high doses of injectable vitamin D formulations by physicians, surgeons, orthopaedicians, gynecologists and other specialties inadvertently. Here, we present an unusual case of a 17-year-old boy who presented with iatrogenic hypercalcemia as a result of combination of milk alkali syndrome with vitamin D intoxication despite being a case of hypoparathyroidism and concomitantly suffering from celiac disease.

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“…Las manifestaciones clínicas de esta intoxicación son afectación renal, en ocasiones con insuficiencia renal (65%), alteraciones gastrointestinales (23%) e hipertensión arterial (52%) 11 . Analíticamente se caracteriza por altas concentraciones séricas de 25-hidroxivitamina D, hipercalcemia, hipercalciuria e hiperfosfatemia 12 .…”

Section: Discussionunclassified