Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men

Chin, Kok‐Yong; Ima‐Nirwana, Soelaiman; Ngah, Wan Zurinah Wan

doi:10.3109/13685538.2015.1034686

Cited by 40 publications

(43 citation statements)

References 35 publications

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“…differences in sun exposure, diet and BMI between sexes). 52,55 Indeed, 25-(OH)D has been significantly and positively associated with total testosterone and SHBG levels before and after adjustment for age and ethnicity, 56 although VitD supplementation per se does not appear to influence testosterone levels. 57 In addition, short-term administration of testosterone does not appear to alter 25-(OH)D levels.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Katrinaki

Kampa

Margioris

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Katrinaki

Kampa

Margioris

et al. 2016

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“…In men, 25(OH)D levels are positively related to T levels,[9–14] and this association varies by vitamin D receptor genotype[15] and may be attenuated after accounting for adiposity. [9] Treatment with vitamin D supplements may increase T levels.…”

Section: Introductionmentioning

confidence: 99%

“…[9] Treatment with vitamin D supplements may increase T levels. [16] Data from testicular cell cultures suggest that vitamin D, especially 1,25-dihydroxyvitamin D3, has a major role in male steroidogenesis.…”

Section: Introductionmentioning

confidence: 99%

Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA)

et al. 2017

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Introduction 25-hydroxyvitamin D [25(OH)D] deficiency has been associated with low testosterone levels in men, but there are conflicting reports of its associations with sex hormones in women. Less is known about whether these associations are independent of adiposity and lifestyle factors, and whether they differ by race/ethnicity. Aim To examine associations of 25(OH)D concentrations with sex hormone levels. Methods Cross-sectional analysis of 3017 men and 2929 women in a multi-ethnic cohort. Main Outcome Measures Testosterone, estradiol, dehydroepiandrosterone (DHEA), sex hormone binding globulin (SHBG), and free testosterone. Results The mean (SD) levels of 25(OH)D in men and women were 25.7(10.4) and 26.1(12.0) ng/ml, respectively. In men, after adjusting for demographic and lifestyle variables, a 10 ng/ml [25 nmol/L] decrease in 25(OH)D was associated with an average difference of −0.70 nmol/L (95%CI −1.36, −0.05) in SHBG and 0.02 percent (0.01, 0.04) in free testosterone, but was not associated with low total testosterone level (<10.41 nmol/L). In women, a 10 ng/ml decrease in 25(OH)D levels was associated with an average difference of −0.01 nmol/L (−0.01, −0.00) for estradiol, −8.29 nmol/L (−10.13, −6.45) for SHBG, 0.06 percent (0.04, 0.07) for free testosterone, and 0.40 nmol/L (0.19, 0.62) for DHEA. There was no significant interaction by race/ethnicity. Conclusions Lower 25(OH)D concentrations were associated with lower SHBG levels and higher free testosterone levels in both men and women, and lower estradiol and higher DHEA levels in women, independent of adiposity and lifestyle. We observed no significant association of 25(OH)D with total testosterone in men. Future studies are needed to determine whether vitamin D supplementation influences sex hormone levels.

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“…[21] VD was significantly and positively associated with T levels before and after adjustment for age and ethnicity. [19] Vitamin D (actually is a potent steroid hormone) which is positively correlated with T, exhibits a concordant seasonal fluctuation [38] , and elevates when T is supplemented in androgen deficient men. [28] Amazingly, the reverse situation is also true, suggesting that VD supplementation might increase T levels.…”

Section: Vitamin D and Endocrine Systemmentioning

confidence: 99%

“…In an animal study on diabetic rats, it was demonstrated that treatment with VD for 12 weeks increased the serum level of T in treatment groups. [26] In a clini- Abnormalities in calcium and phosphorus homeostasis [10,15] Bronchial asthma [4,7] Coronary artery disease [14,16] Erectile dysfunction [9,17,18] Heart failure [10,16] Hypertension [9,14] Hypogonadism [19][20][21][22] Impaired vascular endothelial and smooth muscle function [9,16] Increased immune or inflammatory response [23,24] Infertility [25,26] Metabolic syndrome [10,14,27] Osteoporosis [19,28,29] Peripheral vascular disease [15,30] Respiratory diseases [3,4] Wearing sunscreen clothes cal randomized controlled trial, which is the first on this topic in literature, Pilz et al [39] investigated the effect of VD supplementation on androgens in men. The results were significant and the researchers observed that overweight men with VDD had a clinically meaningful increase in serum T levels after VD supplementation for 1 year.…”

Section: Vitamin D and Endocrine Systemmentioning

confidence: 99%

The role of vitamin D supplementation on erectile function

Talib

Khalafalla

Cangüven

2017

Turkish Journal of Urology

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In the last few years growing evidence highlighted vitamin D (VD) deficiency is one of the several dynamics that associates with increased atherosclerotic cardiovascular (ASCV) diseases. ASCV diseases and erectile dysfunction (ED) share common risk factors such as diabetes mellitus, hypertension, smoking, hyperlipidemia, and a sedentary lifestyle. The aim of this review was to summarize current progress in VD research by focusing effect of low VD level on different body systems and erectile function. Here we examine research linking VD deficiency and ED and discuss how VD influences ED and its classic risk factors that also associate to increased ED risk. We also summarize research indicating that VD associates with reduced risk of several nonvascular contributing factors for ED. Available literature demonstrates relatively high rates of low VD serum levels in ED patients. Based on the preclinical and clinical data available in the literature, to date, we infer that VD play a critical role in maintaining erectile function in humans. Nevertheless, this should also be tested through randomized controlled studies on the effect of VD supplementation with larger population.

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Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men

Abstract: 25(OH)D is significantly associated with total testosterone and SHBG in Malaysian men but this association is BMI-dependent.

Cited by 40 publications

References 35 publications

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA)

The role of vitamin D supplementation on erectile function

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