Vitamin D level in patients with type 1 diabetes and its relation to tissue transglutaminase immunoglobulin A antibodies

Ahmad, Asmaa; Hussein, Omnia A.; Saedii, Ahmed

doi:10.4103/ejim.ejim_31_19

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…Type 1 diabetes mellitus (T1DM) is among the most recognizable chronic autoimmune diseases present at a young age, involving numerous genetic and environmental risk factors in its pathological process [ 1 ]. Children with T1DM face a higher risk of developing celiac disease (CD) compared to the general population [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of celiac-related antibodies and its impact on metabolic control in Egyptian children with type 1 diabetes mellitus

Baseer,

Mohammed,

Elwafa

et al. 2024

BMC Pediatr

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Objective The simultaneous presence of celiac disease and type 1 diabetes (T1DM) is coupled with more hazards of comorbidities and complications. This current study aimed to screen for celiac disease in Egyptian children with type 1 diabetes and evaluate its impact on glycemic control. Methods A cross-sectional study was verified with 200 Egyptian children diagnosed with T1DM and having a diabetic duration of less than five years. Testing for anti-tissue transglutaminase IgA (tTG-IgA), anti-tissue transglutaminase IgG (tTG-IgG), anti-Endomysial IgA (EMA), and Hb A1c levels were done. Results The serological screening revealed that 11 cases (5.5%) tested positive; 8 children with T1DM (4.0%) showed tTG-IgA antibodies ≥ 10 times the upper limit of normal (ULN) with at least one symptom; and 3 cases (1.5%) had levels between 20 and 50 IU/ml (considering a cut-off point of 10 U/ML for positive results). Intestinal biopsy was performed for these three cases, with one case detected to have subtotal villous atrophy, resulting in an overall prevalence of celiac disease in T1DM as 4.5%. Children with positive screening exhibited a higher insulin dose, a higher HbA1c, an increased frequency of hypoglycemic attacks, and recurrent DKA compared to negative cases. A negative correlation was detected between tTG-IgA antibodies with height Z score and hemoglobin level, while a positive correlation was found between tTG-IgA antibodies and HbA1c level. Conclusion Undiagnosed celiac disease in children with T1DM negatively impacted metabolic control and affected their general health.

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Section: Introductionmentioning

confidence: 99%