Vitamin D levels and atopic eczema in infancy and early childhood in Norway: a cohort study

Berents, Teresa Løvold; Carlsen, Karin C. Lødrup; Mowinckel, Petter; Sandvik, Leiv; Skjerven, Håvard Ove; Rolfsjord, Leif Bjarte; Kvenshagen, Bente; Hunderi, Jon Olav Gjengstø; Bradley, Maria; Liedén, Agne; Carlsen, Kai‐Håkon; Thorsby, Per Medbøe; Gjersvik, Petter

doi:10.1111/bjd.14537

Cited by 20 publications

(23 citation statements)

References 56 publications

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“…1) [11, 12]. Inclusion criteria for the bronchiolitis trial was moderate to severe acute bronchiolitis leading to hospitalization before 12 months of age, excluding those having received any glucocorticoid therapy in the preceding four weeks.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…R501X, 2282del4, R2447X and S3247X were obtained in 558 children [12]. Data on vitamin D levels in the children at enrolment and at two years were obtained for 595 and 450 children, respectively [12]. TEWL was measured on non-lesional skin on the lateral part of upper arm, using the open chamber DermaLab USB (Cortex, Hadsund, Denmark) system and accepting ambient temperatures at 20–25 °C and ambient humidity at 20–50% [11].…”

Section: Methodsmentioning

confidence: 99%

“…Statistical power calculation was performed post hoc based on the assumption that the prevalence of AD was 11% in the first year of life [12]. A population size of 499 children would give a statistical power of 68% to detect at least an 4% increase in AD prevalence for one unit increase in weight-for-length and BMI, assuming R 2 of 0.10.…”

Section: Methodsmentioning

confidence: 99%

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Weight-for-length, early weight-gain velocity and atopic dermatitis in infancy and at two years of age: a cohort study

et al. 2017

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BackgroundOverweight and atopic dermatitis (AD) are major health problems in most industrialised countries, but the relationship between overweight and AD in infants and young children is unclear. We investigated if weight-for-length at birth, in infancy and at two years, as well as early weight-gain velocity, are associated with the development of AD in early life.MethodsCohort study of infants (n = 642), all living in south-east Norway, hospitalized with acute bronchiolitis (n = 404) or recruited from the general population (n = 238), examined at mean age 5.1 months (enrolment) and at a two-year follow-up visit (n = 499; 78%) at mean age 24.6 months. Exposures were weight-for-length (g/cm) at birth, enrolment and two-year follow-up, and early weight-gain velocity (gram/month from birth to enrolment). Excessive weight-for-length was defined as weight-for-length >95th percentile of WHO child-growth standards. Data on weight-for-length at the three time points were obtained for 435, 428 and 473 children. AD was diagnosed according to the Hanifin & Rajka criteria or from a history of physician-diagnosed AD. We performed multivariate analyses with weight-for-length at birth, at enrolment and at the two-year follow-up visit and with early weight gain velocity for the endpoint AD at each visit.ResultsIn adjusted analyses, excessive weight-for-length at enrolment was associated with concurrent AD (OR 3.03; 95% CI 1.23–7.50) and with AD at two years (OR 2.40; 1.11–5.17). In infants without AD, weight-for-length at enrolment increased the risk of AD at two years, with OR being 1.02 (95% CI 1.00–1.04) per increased gram/cm. AD at two years was not associated with concurrent excessive weight-for-length, nor was AD at any time associated with weight-for-length at birth or with early weight-gain velocity.ConclusionsThe results suggest that overweight in infancy may contribute to the development of AD in early life, highlighting the need for child health-care professionals to address potential overweight and atopic disease when advising infants’ caregivers.Trial registrationClinicalTrials.gov number, NCT00817466, EudraCT number, 2009–012667-34.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Weight-for-length, early weight-gain velocity and atopic dermatitis in infancy and at two years of age: a cohort study

et al. 2017

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“…All of these functions support its role in the pathophysiology of AD . While low serum levels of VD have been linked to AD severity in certain populations, these findings have not been replicated in others . Therefore, the evidence to support the improvement of AD with VD supplementation is still weak …”

Section: Introductionmentioning

confidence: 99%

The association between atopic dermatitis and serum 25‐hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features—A cross‐sectional study

Sanmartín¹,

Pardos

Doste³

et al. 2020

Pediatric Dermatology

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Background Previous studies have linked low serum vitamin D (VD) or 25‐hydroxyvitamin D (25(OH)D) levels with increased severity of atopic dermatitis (AD) in children. Objective To investigate the association between serum VD (25(OH)D) levels and AD and AD severity, considering the influence of diet and sun exposure. Methods We performed a prospective cross‐sectional study of healthy controls and children diagnosed with AD. Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun‐induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test. Results The study population consisted of 105 healthy controls and 134 AD patients. Serum 25(OH)D levels were significantly lower in moderate and severe AD than in mild AD, although this association was only significant for patients with light Fitzpatrick skin type (mean(SD) 36.7 (11.9) ng/mL; moderate 28.8 [11.5] ng/mL; and severe 27.6 [12.1] ng/mL, P = .045). Logistic regression analysis revealed a positive association between severe AD and both positive ImmunoCAP Phadiatop test and BMI. Conclusion Our data support an association between VD deficiency and AD severity only in patients with light complexion.

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Associations between serum 25-hydroxyvitamin D levels and allergic sensitization in early childhood

Guo

Deng

et al. 2020

Allergologia et Immunopathologia

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Vitamin D levels and atopic eczema in infancy and early childhood in Norway: a cohort study

Abstract: In this cohort of young children in Norway, we found no association between vitD levels and the presence or severity of AE.

Cited by 20 publications

References 56 publications

Weight-for-length, early weight-gain velocity and atopic dermatitis in infancy and at two years of age: a cohort study

Weight-for-length, early weight-gain velocity and atopic dermatitis in infancy and at two years of age: a cohort study

The association between atopic dermatitis and serum 25‐hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features—A cross‐sectional study

Associations between serum 25-hydroxyvitamin D levels and allergic sensitization in early childhood

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