Vitamin D levels and bone mineral density in 174 postmenopausal women

Poiană, Cătălina; Cârșote, Mara; Neacşu, Elena; Barbu, Carmen; Gruia, Adriana; Samoila, Ramona; Ene, Cristina

doi:10.1016/j.bone.2009.03.296

Cited by 2 publications

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“…, and competitive protein-binding techniques, in one 41 . In five studies, the laboratory technique employed was not reported [42][43][44][45][46] .…”

Section: Methodsmentioning

confidence: 99%

Prevalence of hypovitaminosis D in postmenopausal women: a systematic review

Valladares

Simões

Bernardo

et al. 2019

Rev. Assoc. Med. Bras.

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SUMMARY BACKGROUND: Hypovitaminosis D is considered a global public health issue. Knowledge of its true dimensions will allow us to design interventions and plan preventive measures that can have a significant impact on human health. OBJECTIVES: The aim of this study was to evaluate the prevalence of hypovitaminosis D, defined as a serum 25-hydroxyvitamin D concentration < 30 ng/ml, in postmenopausal women around the world, as well as to identify the potential associated factors. METHODS: A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses recommendations. Specific search terms were consulted in Medline, Excerpta Medica, and Latin-American and Caribbean Health Sciences Literature databases, with no restriction for the year or language of publication. RESULTS: Of 451 studies initially identified, 32 were selected for analysis. Collectively, those 32 studies evaluated 21,236 postmenopausal women, of whom 16,440 (77.4%) had serum 25-hydroxyvitamin D concentrations < 30 ng/ml. The reported prevalence of hypovitaminosis D ranged from 29% (in the United States) to 99.4% (in China). In six of the studies, the prevalence was above 90%. CONCLUSIONS: If the criterion is the 30 ng/ml cut-off point, the majority of postmenopausal women in the world could be classified as having hypovitaminosis D. Among the studies evaluated, the lowest prevalence reported was nearly 30%. Neither latitude, region of the world, nor laboratory methodology were found to be associated with the prevalence of hypovitaminosis D.

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“…, and competitive protein-binding techniques, in one 41 . In five studies, the laboratory technique employed was not reported [42][43][44][45][46] .…”

Section: Methodsmentioning

confidence: 99%

Prevalence of hypovitaminosis D in postmenopausal women: a systematic review

Valladares

Simões

Bernardo

et al. 2019

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

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Ethinylestradiol liposome preparation and its effects on ovariectomized rats’ osteoporosis

Lu¹,

Ma²,

Hu³

et al. 2011

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Ethinylestradiol liposome (EEL) was prepared by thin film evaporation-extrusion technique and its effects on ovariectomized rat osteoporosis were investigated. The liposomes were characterized with clear homogeneous lamellar vesicles and had the average size of 200 ± 1.5 nm. The long term stability of liposome formulations were tested over a 28-day period at 4°C and ethinylestradiol retention was approximately 80% up to 28 day. Release data of ethinylestradiol was tested in PBS pH 7.4 at 37°C using a dialysis method and its release profiles were biphasic, showing a relatively large burst effect over the first four hours, followed by a slower release phase. Ovariectomized rat model was used to investigate EEL effects on osteoporosis. After three months post-surgery, the rats were divided into two groups and injected intraperitoneally (IP) with 2 μg per kilogram per day of either free ethinylestradiol (EE) or encapsulated ethinlyestradiol (EEL). At termination of one month IP injection, the rats were killed and the bone mineral density (BMD) and alkaline phosphatase (ALP) were measured. BMD value in free EE group increased by 20.3 %, while it increased by 37.8 % in EEL group. According to ALP value, the two treatment groups increased by 28.6 % and 42.0 %, respectively. These data indicated that ethinlyetradiol liposome had better effect than that of free ethinylestradiol did in treatment of the ovariectomized rats' osteoporosis. But the metabolites and biodistribution of ethinylestradiol liposome in vivo need to investigate in the further research work.

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Vitamin D levels and bone mineral density in 174 postmenopausal women

Cited by 2 publications

References 0 publications

Prevalence of hypovitaminosis D in postmenopausal women: a systematic review

Prevalence of hypovitaminosis D in postmenopausal women: a systematic review

Ethinylestradiol liposome preparation and its effects on ovariectomized rats’ osteoporosis

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