Vitamin D levels and vitamin D receptor variants are associated with chronic heart failure in Chinese patients

Abstract

BackgroundVitamin D is an indispensable molecule for human health. Wide ranges of diseases are linked with vitamin D deficiencies. Role of vitamin D in chronic heart failure has been demonstrated in different populations; however, reports are limited in Chinese population. Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling. In the present study, we hypothesized that both vitamin D levels and VDR variants could be associated with the development of chronic heart failure.Materials and MethodsWe enrolled 145, chronic heart failure patients those admitted to Department of Cardiothoracic Surgery, Beijing Luhe Hospital of Capital Medical University and fulfilled NYHA inclusions criteria. In addition, ninety healthy subjects from similar geographical location were enrolled as healthy controls. Plasma levels of vitamin D were quantified by ELISA. VDR variants (BsmI, ApaI, TaqI, and FokI) were genotyped by PCR‐RFLP.ResultsPlasma levels of vitamin D were significantly lower in chronic heart patients compared to healthy controls. Heterozygous and minor allele for FokI and TaqI polymorphisms were significantly higher in heart failure patients when compared to healthy controls. In addition, combined analysis of vitamin D levels and VDR mutants revealed association of vitamin D deficiencies and VDR mutants with chronic heart failure.ConclusionsThe results of the present investigation showed an important role of vitamin D and VDR variants with chronic heart failure.

Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review

“…The included studies were published between 2007 and 2021. Twenty-three studies were conducted in China [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]; ten in the United States [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]; five in Iran [ 47 , 48 , 49 , 50 , 51 ]; four in Italy [ 52 , 53 , 54 , 55 ]; three in the Netherlands [ 56 , 57 , 58 ]; three in Germany [ 59 , 60 , 61 ]; two in Taiwan [ 62 , 63 ]; two in Australia [ 64 , 65 ]; and one each in New Zealand [ 66 …”

“…The included studies assessed different genetic components. Twenty-four studies involved the assessment of single-nucleotide polymorphism (SNP) [ 18 , 19 , 20 , 21 , 26 , 28 , 33 , 39 , 40 , 42 , 43 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 62 , 63 , 67 , 69 , 72 , 74 ], eight studies were on the transcriptome [ 23 , 29 , 36 , 41 , 46 , 54 , 61 , 71 ], twenty-three studied microRNA (miRNA) [ 14 , 15 , 16 , 22 , 23 , 24 , 29 , 30 , 31 , 32 , 37 , 38 , 44 , 55 , 56 , 57 , 58 , 61 , 65 , 66 , 68 , …”

“…Twenty-four of the included studies reported the association of polymorphisms of specific genes in HF [ 18 , 19 , 20 , 21 , 26 , 28 , 33 , 39 , 40 , 42 , 43 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 62 , 63 , 67 , 69 , 72 , 74 ]. These genes included HDC [ 18 ], VDR [ 19 ], ADA [ 20 ], HRH3 [ 21 ], IL-17A/IL-17RA [ 26 ], i [ 28 ], MHRT [ 33 ], HSPB7 and FRMD4B [ 39 ], CLCNKA [ 40 ], TGFBR3 [ 42 ], TNF-α [ 47 ], IL-4 [ 48 ], IL-1 [ 49 ], IL-2 [ 50 ], IL-10 and TGF-β1 [ 51 ], KCNE1 [ 52 ], AGTR1 [ 62 ], MYBPC3 [ 63 ], MIF [ 67 ], LEP [ 69 ], AGT and ACE [ 74 ]. All of these studies involved the examination of SNPs in peripheral blood.…”

Diminished 25‐OH vitamin D3 levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

“…19 There is growing evidence suggesting an association of lower vitamin D levels with susceptibility to CAD and mortality. 20,21 A recent report highlighted connotation between deficient vitamin D levels and severity of CAD. 22 In addition to vitamin D levels, vitamin D receptors (VDR) polymorphisms are also associated with genetic susceptibility to T2D and CAD patients.…”

“…Supplementation of vitamin D in patients with T2D has shown promising findings by lowering blood cholesterols and HDL levels . There is growing evidence suggesting an association of lower vitamin D levels with susceptibility to CAD and mortality . A recent report highlighted connotation between deficient vitamin D levels and severity of CAD …”