Vitamin D levels in acne vulgaris patients treated with oral isotretinoin

El‐Hamd, Mohammed Abu; Taieb, Moustafa A El; Ibrahim, Hassan; Aly, Sanaa Shaker

doi:10.1111/jocd.12503

Cited by 30 publications

(42 citation statements)

References 20 publications

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“…In this study, patients showed significantly lower serum 25(OH)D 3 concentration when compared to controls, suggesting that VitD deficiency may be a risk factor for the development of AV. In agreement, previous studied stated that VitD deficiency causes increase sebum production, follicular hyperkeratinization, P acnes overgrowth and exacerbates inflammation in AV . P acnes , via toll‐like receptors, are responsible for CD4 + lymphocytes and macrophages activation which aggravates the pilosebaceous vasculature, pronounces ductal hyperproliferation, and in turn promotes more microbial proliferation .…”

Section: Discussionsupporting

confidence: 90%

“…In agreement, previous studied stated that VitD deficiency causes increase sebum production, follicular hyperkeratinization, P acnes overgrowth and exacerbates inflammation in AV. 1,9,10 P acnes, via toll-like receptors, are responsible for CD4 + lymphocytes and macrophages activation which aggravates the pilosebaceous vasculature, pronounces ductal hyperproliferation, and in turn promotes more microbial proliferation. 10,11 VitD increases forkhead box 1 (FOXO1) transcription and downregulates mTORC1, which is thought to be a main regulator of cell growth and lipogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…1,9,10 P acnes, via toll-like receptors, are responsible for CD4 + lymphocytes and macrophages activation which aggravates the pilosebaceous vasculature, pronounces ductal hyperproliferation, and in turn promotes more microbial proliferation. 10,11 VitD increases forkhead box 1 (FOXO1) transcription and downregulates mTORC1, which is thought to be a main regulator of cell growth and lipogenesis. 12 Thus, VitD-deficient state may be involved in acne pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

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Associations among two vitamin D receptor (VDR) gene polymorphisms (ApaI and TaqI) in acne vulgaris: A pilot susceptibility study

Swelam

El-Barbary

Saudi

et al. 2018

J of Cosmetic Dermatology

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Associations among two vitamin D receptor (VDR) gene polymorphisms (ApaI and TaqI) in acne vulgaris: A pilot susceptibility study

Swelam

El-Barbary

Saudi

et al. 2018

J of Cosmetic Dermatology

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“…Recently, it is found that vitamin D deficiency is associated with many chronic diseases including cancers, cardiovascular diseases, metabolic syndrome, infectious and autoimmune skin diseases, also, AV 19,21,22 . It is considered that vitamin D is important not only in calcium homeostasis, but also in immune system regulation, cell growth and differentiation 23 .…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D is also known as anticomedogenic and antioxidant. The deficiency of vitamin D may facilitate the pathogenesis of AV 6,19 . The relationship between vitamin D and AV depends on possible anti-inflammatory effects of vitamin D 24 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Serum 25 Hydroxy Vitamin D Level on Isotretinoin-Induced Musculoskeletal Symptoms: A Cross-Sectional Study

Mülkoğlu

Karaosmanoğlu

2020

Sci Rep

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Isotretinoin (ISO) is a drug which is used for the treatment of severe and refractory acne vulgaris (AV), over the last few decades. The drug has various musculoskeletal side effects. The aim of this study was to investigate relationship between serum 25 hydroxy (OH) vitamin D levels and the ISOinduced musculoskeletal side effects in patients with AV. We included 87 patients receiving ISO and had musculoskeletal symptoms as adverse effect (AE) group. Another 90 patients receiving ISO for AV and had any musculoskeletal complaints were recruited as control (C) group. Locomotor system examination of the patients was performed by the same clinician. Serum 25 OH vitamin D levels of the all participants were measured. Patients in the AE group were divided into three subgroups by serum 25 OH vitamin D levels. Patients with serum 25 OH vitamin D level lower than 10 ng/ml was classified as Group I, the ones between 10-20 ng/ml as Group II and those higher than 20 ng/ml were classified as Group III. AE and C groups were similar in terms of age and sex (p > 0.05). There was no statistically significant difference in the mean serum vitamin D levels between two groups (p = 0.17). Also, there was no significant difference in number of arthralgia (p = 0.30), myalgia (p = 0.29), low back pain (p = 0.10) and sacroiliitis (p = 0.17) between three subgroups in AE group. In addition, we found no statistically significant correlation between the serum vitamin D levels and age, cumulative dose of ISO, arthralgia, myalgia and sacroiliitis parameters in AE group (p > 0.05). Serum 25 OH vitamin D levels between the AE and C groups were similar. We also found that no significant difference in musculoskeletal adverse events between AE subgroups. Therefore, it can be concluded that vitamin D deficiency has no effect on the musculoskeletal adverse events in patients receiving ISO.

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Oral Supplements and Dermatology: A Review

Reeves,

Luks

2024

Dermatological Reviews

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IntroductionThere is growing interest in the utility of oral supplements for improving overall health and wellness. Dietary supplements and nutraceuticals with antioxidant and anti‐inflammatory properties have gained particular attention for their potential to optimize skin health. This review summarizes evidence for the following vitamins, minerals, and natural compounds in the realm of dermatology: niacinamide, vitamin D, vitamin C, vitamin E, zinc, omega‐3 fatty acids, probiotics, polyphenols, Polypodium leucotomos, coenzyme Q10, and astaxanthin.ResultsNiacinamide and vitamins C, D, and E may all protect against UV damage. Zinc and omega‐3 fatty acids may be useful for the treatment of acne and for minimizing side effects from isotretinoin. There is convincing evidence for the utility of probiotics in complementing standard treatments for acne, psoriasis, and atopic dermatitis. Collagen supplements have demonstrated anti‐aging effects but should not be routinely recommended due to their unreliable quality. Antioxidants such as P. leucotomos, coenzyme Q10, astaxanthin, and polyphenols may play a role in anti‐aging and photoprotection.ConclusionOral supplements may play a beneficial role in skin health, namely in terms of photoprotection, anti‐aging, and inflammatory conditions such as atopic dermatitis, acne, and psoriasis. However, further high‐quality studies are needed.

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Vitamin D levels in acne vulgaris patients treated with oral isotretinoin

Abstract: This study concluded that vitamin D may play a potential role in pathogenesis of acne vulgaris or acne vulgaris may have a negative effect on vitamin D synthesis. Further studies are needed to confirm these potential relations.

Cited by 30 publications

References 20 publications

Associations among two vitamin D receptor (VDR) gene polymorphisms (ApaI and TaqI) in acne vulgaris: A pilot susceptibility study

Associations among two vitamin D receptor (VDR) gene polymorphisms (ApaI and TaqI) in acne vulgaris: A pilot susceptibility study

Effect of Serum 25 Hydroxy Vitamin D Level on Isotretinoin-Induced Musculoskeletal Symptoms: A Cross-Sectional Study

Oral Supplements and Dermatology: A Review

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