Vitamin D levels in children with attention deficit hyperactivity disorder: Association with seasonal and geographical variation, supplementation, inattention severity, and theta:beta ratio

Miller, Melissa C.; Pan, Xueliang; Arnold, L. Eugene; Mulligan, Arielle; Connor, Shea; Bergman, Rachel; deBeus, Roger; Roley‐Roberts, Michelle E.

doi:10.1016/j.biopsycho.2021.108099

Cited by 7 publications

(7 citation statements)

References 44 publications

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“…This association is not universally replicated [ 106 , 107 ]; however, the mean population 25(OH)D 3 levels in these later studies were much higher, making the association difficult to test. Randomised controlled trials of cholecalciferol supplementation in children with ASD or ADHD show diverse outcomes, some showed no beneficial effects and others reported some symptom relief [ 108 , 109 , 110 , 111 , 112 , 113 , 114 ]. In the future, trials examining vitamin D levels in mothers/children prior to supplementation are required as supplementing vitamin D-sufficient mothers or children is likely to have minimal effect, as shown in other clinical trials with vitamin D [ 115 ].…”

Section: Developmental Vitamin D Deficiency Effect On Brain Function ...mentioning

confidence: 99%

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Cui

Eyles

2022

Nutrients

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Twenty of the last one hundred years of vitamin D research have involved investigations of the brain as a target organ for this hormone. Our group was one of the first to investigate brain outcomes resulting from primarily restricting dietary vitamin D during brain development. With the advent of new molecular and neurochemical techniques in neuroscience, there has been increasing interest in the potential neuroprotective actions of vitamin D in response to a variety of adverse exposures and how this hormone could affect brain development and function. Rather than provide an exhaustive summary of this data and a listing of neurological or psychiatric conditions that vitamin D deficiency has been associated with, here, we provide an update on the actions of this vitamin in the brain and cellular processes vitamin D may be targeting in psychiatry and neurology.

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Section: Developmental Vitamin D Deficiency Effect On Brain Function ...mentioning

confidence: 99%

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Cui

Eyles

2022

Nutrients

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“…14 The only review to include a meta-analysis of observational vitamin D studies found null associations with language or any other neurodevelopmental outcome. 15 A handful of small randomised controlled trials of vitamin D supplementation with child neurodevelopment assessments are emerging, [58][59][60][61][62][63][64][65][66][67][68][69][70][71] although only two have intervened during pregnancy. 33,72 Over 600 pregnant Danish women were randomised to either 2800 IU or 400 IU vitamin D 3 per day and a mixture of parent-reported and psychologist assessments was conducted at regular intervals between 1 and 6 years of age.…”

Section: Discussionmentioning

confidence: 99%

Association of cord blood vitamin D with child neurodevelopment at 7 years of age

Gould,

Cuthbert,

Yelland

et al. 2024

J Paediatrics Child Health

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AimThe role of fetal vitamin D [25‐hydroxyvitamin D (25(OH)D)], one of the nuclear steroid transcription regulators, and brain development is unclear. We previously found a weak but persistent association between cord blood 25(OH)D and child language abilities at 18 months and 4 years of age, but no association with cognition or behaviour. The aim of this study was to investigate the association between cord blood 25(OH)D and a range of neurodevelopmental outcomes in these same children at 7 years of age.MethodsCord blood samples from 250 Australian mother–child pairs were analysed for 25(OH)D by mass spectroscopy. Children underwent tests of cognition, language, academic abilities and executive functions with a trained assessor at 7 years of age. Caregivers completed questionnaires to rate their child's behaviour and executive functioning in the home environment. Associations between standardised 25(OH)D and outcomes were assessed using regression models, taking into account possible social and demographic confounders.ResultsStandardised 25(OH)D in cord blood was not associated with any test or parent‐rated scores. Nor was there any association with the risk of having a poor test or parent‐rated score. Likewise, cord blood 25(OH)D categorised as <25, 25–50 and >50 nmol/L was not associated with test scores or parent‐rated scores.ConclusionsThere was no evidence that cord blood vitamin D concentration or deficiency was associated with cognition, language, academic abilities, executive functioning or behaviour at 7 years of age.

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“…The higher the score, the more severe the ADHD symptoms. [16] : 2 mL of fasting venous blood was collected in the morning, and the serum was isolated and stored at −70°C. Chemiluminescence immunoassay was used to detect the level of 25(OH)D in the serum, which was divided into 3 horizontal segments: adequate level (20-100 ng/mL); insufficient level (15-19.9 ng/mL); and deficient level (<15 ng/mL).…”

Section: Adhd Scorementioning

confidence: 99%

Effect of 25 hydroxyvitamin D on attention deficit and hyperactivity in school-age children with ADHD

Yang,

Yuan,

Qiu

et al. 2023

Medicine

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Background: To observe the serum levels of 25 hydroxyvitamin D [25 (OH) D] in healthy school-age children and children with attention deficit hyperactivity disorder (ADHD) and to analyze the effects of serum 25 (OH) D on the symptoms of attention deficit and hyperactivity in school-age children with ADHD. Methods: According to the Diagnostic and Statistical Manual of Mental Disorders DSM-IV diagnostic criteria for ADHD in children, 80 healthy children aged 6 years or less than 10 years old and children diagnosed with ADHD in the Department of Rehabilitation Medicine, Department of Pediatrics and Department of Physical Examination of our hospital were randomly selected as research subjects. The serum 25 (OH) D level, attention deficit hyperactivity (Swanson, Nolan, and Pelham, version IV [SNAP-IV] parental version) score and Conners child behavior (PSQ) index were observed and compared between the 2 groups. In addition, the children with ADHD whose serum 25 (OH) D was lower than normal were treated with supplemental VitD3, and the changes in serum 25 (OH) D, SNAP-IV parental score and PSQ index of ADHD children were observed and compared. Results: Serum 25(OH)D was insufficient or deficient in 26 healthy children, but the SNAP-IV score and PSQ index were normal. Serum 25(OH)D was lower than normal in 69 patients in the ADHD group, which was negatively correlated with SNAP-IV score (r = −0.3479, P = .0034) and negatively correlated with PSQ index (r = −0.3566, P = .0026). After vitamin D3 (VitD3) supplementation in 69 children with serum 25(OH)D levels lower than the normal ADHD group, it was found that the SNAP-IV score (r = −0.4654, P = .0037) and PSQ index (r = −0.5680, P = .0002) of 34 children with ADHD were negatively correlated with the increase in serum 25(OH)D. The SNAP-IV score and PSQ index of the other 35 children with ADHD showed no correlation with the increase in serum 25 (OH) D (P > .05). Conclusion subsections: Serum 25(OH)D levels lower than normal are more common in school-age children, and levels lower than normal are not the key pathogenic factor of ADHD in school-age children, but serum 25(OH)D levels lower than normal may be the upregulation factor of attention deficit and hyperactivity disorder expression in some school-age children with ADHD. The lower level of serum 25(OH)D may be closely related to the severity of ADHD symptoms in some children.

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Vitamin D levels in children with attention deficit hyperactivity disorder: Association with seasonal and geographical variation, supplementation, inattention severity, and theta:beta ratio

Cited by 7 publications

References 44 publications

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Association of cord blood vitamin D with child neurodevelopment at 7 years of age

Effect of 25 hydroxyvitamin D on attention deficit and hyperactivity in school-age children with ADHD

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