Vitamin D levels in Greek patients with systemic lupus erythematosus

Athanassiou, Lambros; Kostoglou-Athanassiou, Ifigenia; Tsakiridis, Pavlos; Devetzi, Eirini; Mavroudi, Maria; Fytas, Pantelis; Koutsilieris, Michael; Athanassiou, Panagiotis

doi:10.1177/09612033211066462

Cited by 8 publications

(6 citation statements)

References 45 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For a long time, vitamin D deficiency has been known to play a vital role in the pathogenesis of autoimmune diseases ( 27 ). Reports have shown that patients with SLE have significantly insufficient vitamin D levels ( 13 ), as do those with other immune diseases, such as multiple sclerosis ( 14 ), autoimmune thyroid disorders ( 15 ), and antiphospholipid syndrome ( 16 ). There is increasing evidence that IgA vasculitis patients also have lower serum levels of vitamin D than healthy children, but most of these previous studies had small sample sizes ( 19 - 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to its well-known functions of regulating calcium and phosphorus metabolism, and maintaining bone health, vitamin D has a broad regulatory effect on the immune system ( 11 , 12 ). Studies have shown that vitamin D deficiency is prevalent in autoimmune diseases, such as systemic lupus erythematosus (SLE) ( 13 ), multiple sclerosis ( 14 ), autoimmune thyroid disorders ( 15 ), and antiphospholipid syndrome ( 16 ). A systematic review showed that SLE patients had significantly lower vitamin D levels than healthy controls ( 13 ), and lower vitamin D levels were associated with SLE disease pathogenesis ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The comparisons of vitamin D3 levels in IgA vasculitis across different subgroups and healthy children: a comparative study

Wang¹,

Ye²

2023

Transl Pediatr

View full text Add to dashboard Cite

Background IgA vasculitis is the most common form of vasculitis in children. Vitamin D deficiency has been observed to contribute to immune function and the pathogenesis of various immune diseases. However, at present, only a few studies with small sample sizes have shown that IgA vasculitis patients have lower vitamin D levels than healthy children. Thus, we conduct a large study to investigate the significance of serum 25-hydroxyvitamin D3 (25(OH)D) levels of children with IgA vasculitis across different subgroups and healthy children. Methods In this retrospective study, 1,063 children were recruited from the Ningbo Women and Children’s Hospital between February 2017 and October 2019, including 663 patients hospitalized with IgA vasculitis and 400 healthy examination children who served as the control group at the same time. There wasn’t any bias in the season. The healthy group came from children who underwent normal physical examination. The 663 IgA vasculitis patients were then divided into the IgA vasculitis-nephritis and non-IgA vasculitis-nephritis groups, streptococcal-infection and no-streptococcal-infection groups, gastrointestinal-involvement and no-gastrointestinal-involvement groups, and joint-involvement and no-joint-involvement groups. The serum 25(OH)D levels at disease onset were analyzed. All the participants were followed up for 6 months from the date of onset. Results The serum 25(OH)D levels of the IgA vasculitis group (15.47±6.58 ng/mL) were significantly lower than those of the healthy control group (22.48±6.24 ng/mL) (P<0.01). There were no significant differences in terms of age and sex between the IgA vasculitis and healthy control group. Further, among the IgA vasculitis patients serum 25(OH)D levels were reduced in the IgA vasculitis-nephritis (12.99±4.92 ng/mL), streptococcal-infection (14.2±6.06 ng/mL), and gastrointestinal-involvement (14.43±6.33 ng/mL) groups (P=0.00, 0.004, 0.002, respectively). The vitamin D levels with IgA vasculitis were significantly lower in winter and spring than summer and autumn. Conversely, the joint-involvement group did not show a significant reduction in vitamin D levels compared to no joints involved group. Conclusions IgA vasculitis patients have reduced vitamin D levels, which suggests that vitamin D deficiency may be involved in the development of IgA vasculitis. Vitamin D supplementation may reduce the incidence of IgA vasculitis, and maintaining high vitamin D levels in IgA vasculitis patients may prevent renal damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The comparisons of vitamin D3 levels in IgA vasculitis across different subgroups and healthy children: a comparative study

Wang¹,

Ye²

2023

Transl Pediatr

View full text Add to dashboard Cite

show abstract

“…Autoantibodies against vitamin D may also be related to its low levels in SLE [ 144 , 150 ]. Low C 3 and C 4 levels may be related to low vitamin D levels in SLE, and both are related to increased disease activity [ 151 , 152 ]. Lupus nephritis may be related to low vitamin D [ 152 , 153 ].…”

Section: Systemic Lupus Erythematosus and Vitamin Dmentioning

confidence: 99%

“…Low C 3 and C 4 levels may be related to low vitamin D levels in SLE, and both are related to increased disease activity [ 151 , 152 ]. Lupus nephritis may be related to low vitamin D [ 152 , 153 ]. In lupus and nephritis patients, VDR expression was studied with immunohistochemistry in renal biopsy specimens.…”

Section: Systemic Lupus Erythematosus and Vitamin Dmentioning

confidence: 99%

Vitamin D and Autoimmune Rheumatic Diseases

Athanassiou

Kostoglou-Athanassiou

Koutsilieris

et al. 2023

Biomolecules

Self Cite

View full text Add to dashboard Cite

Vitamin D is a steroid hormone with potent immune-modulating properties. It has been shown to stimulate innate immunity and induce immune tolerance. Extensive research efforts have shown that vitamin D deficiency may be related to the development of autoimmune diseases. Vitamin D deficiency has been observed in patients with rheumatoid arthritis (RA) and has been shown to be inversely related to disease activity. Moreover, vitamin D deficiency may be implicated in the pathogenesis of the disease. Vitamin D deficiency has also been observed in patients with systemic lupus erythematosus (SLE). It has been found to be inversely related to disease activity and renal involvement. In addition, vitamin D receptor polymorphisms have been studied in SLE. Vitamin D levels have been studied in patients with Sjogren’s syndrome, and vitamin D deficiency may be related to neuropathy and the development of lymphoma in the context of Sjogren’s syndrome. Vitamin D deficiency has been observed in ankylosing spondylitis, psoriatic arthritis (PsA), and idiopathic inflammatory myopathies. Vitamin D deficiency has also been observed in systemic sclerosis. Vitamin D deficiency may be implicated in the pathogenesis of autoimmunity, and it may be administered to prevent autoimmune disease and reduce pain in the context of autoimmune rheumatic disorders.

show abstract

“…The administration of vitamin D (1,200 IU/d vs. placebo) over 4 months (from December to March) significantly reduced the incidence of influenza A in school-aged children by 42% ( Urashima et al, 2010 ). Vitamin D deficiency has also been associated with various autoimmune diseases, including systemic lupus erythematosus ( Athanassiou et al, 2022 ). More recently, vitamin D deficiency was proposed as a possible factor in the susceptibility, severity, and mortality of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection ( Jain and Parsanathan, 2020 ; Razdan et al, 2020 ).…”

Section: Vitaminsmentioning

confidence: 99%

Nutraceuticals as Modulators of Immune Function: A Review of Potential Therapeutic Effects

Medoro,

Davinelli,

Colletti

et al. 2023

Prev. Nutr. Food Sci.

View full text Add to dashboard Cite

Dietary supplementation with nutraceuticals can promote optimal immune system activation, modulating different pathways that enhance immune defenses. Therefore, the immunity-boosting effects of nutraceuticals encompass not only immunomodulatory but also antioxidant, antitumor, antiviral, antibacterial, and antifungal properties, with therapeutic effects against diverse pathological conditions. However, the complexity of the pathways that regulate the immune system, numerous mechanisms of action, and heterogeneity of the immunodeficiencies, and subjects treated make their application in the clinical field difficult. Some nutraceuticals appear to safely improve immune system function, particularly by preventing viral and bacterial infections in specific groups, such as children, the elderly, and athletes, as well as in frail patients, such as those affected by autoimmune diseases, chronic diseases, or cancer. Several nutraceuticals, such as vitamins, mineral salts, polyunsaturated omega-3 fatty acids, many types of phytocompounds, and probiotic strains, have the most consolidated evidence in humans. In most cases, further large and long-term randomized clinical trials are needed to confirm the available preliminary positive data.

show abstract

Vitamin D levels in Greek patients with systemic lupus erythematosus

Cited by 8 publications

References 45 publications

The comparisons of vitamin D3 levels in IgA vasculitis across different subgroups and healthy children: a comparative study

The comparisons of vitamin D3 levels in IgA vasculitis across different subgroups and healthy children: a comparative study

Vitamin D and Autoimmune Rheumatic Diseases

Nutraceuticals as Modulators of Immune Function: A Review of Potential Therapeutic Effects

Contact Info

Product

Resources

About