Vitamin D levels in patients with chronic hepatitis B virus infection and naturally immunized individuals

Demir, Canan; Demir, Mehmet

doi:10.7243/2052-6954-1-2

Cited by 10 publications

(10 citation statements)

References 30 publications

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“…A decrease of 25 OH vitamin D associated with increased iPTH levels have been reported in patients with chronic hepatitis C or B virus infection [16,17,18]. Similarly, in the HCV-infected HD patients, higher iPTH and ALP have been found [1,19].…”

Section: Discussionmentioning

confidence: 90%

Hepatitis B and C Virus Infection in the Hemodialysis Population from Three Romanian Regions

Schiller

Timar²,

Siriopol³

et al. 2015

Nephron

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Background: After 10 years of systematically nationwide applied measures for reduction of infection risk, in this national prospective observational study, we reassessed the prevalence of hepatitis virus infection prevalence and its influence on the outcome of end-stage kidney disease (ESKD) patients treated with hemodialysis. Methods: Six-hundred ESKD patients (332 men and 268 women, median age 56 years) treated with chronic HD in seven centers from all the historical regions of Romania have been assigned to this study on 1st of November 2010. The aims of this study were to reevaluate the prevalence of the hepatitis B and C virus infection in a HD population from Romania after 10 years of systematically nationwide applied measures for reduction of infection risk and also to assess the impact of these infections on the prognosis of HD patients. Results: HBsAg was positive in 9.5% (n = 57) of the patients, anti-HCV antibodies were detected in 27.3% (n = 164) and 5% (n = 30) were positive for both HBV and HCV infection. The mortality risk was significantly influenced only by age, the presence of coronary artery disease and the 25 OH vitamin D levels. Conclusions: This study shows that the systematically nationwide applied measures for reduction of infection risk significantly decreased HV infection prevalence in HD patients in Romania. The presence of HV infection did not significantly influence the mortality risk in this population.

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Section: Discussionmentioning

confidence: 90%

Hepatitis B and C Virus Infection in the Hemodialysis Population from Three Romanian Regions

Schiller

Timar²,

Siriopol³

et al. 2015

Nephron

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“…In group (I), which represented the inactive HBV disease, the level of vitamin D was significantly higher than group (II), which represented the active HBV infection, suggesting the immunomodulatory effect of vitamin D and its role as anti-microbial agent. [6] This could explain the high viral replication in group (II) compared to group (I) and its subsequent impact on the elevated AST, ALT and AFP levels and relatively reduced levels of albumin in group (II) compared to group (I). The absence of liver cirrhosis and other confounding factors in these groups confirms to a great extent the role of vitamin D in HBV replication and its ability to transform its status from an inactive to an active disease.…”

Section: Discussionmentioning

confidence: 95%

“…Due to its immunomodulatory role, there is growing evidence about the interrelationship between vitamin D and different chronic liver diseases in different stages. [3] Different studies have shown a wide, universal agreement of vitamin D deficiency in patients with chronic hepatitis C virus (HCV) infection, [4,5] chronic HBV, [6,7] nonalcoholic steatohepatitis (NASH) [8] and hepatocellular carcinoma (HCC) [9] with contradictory reports about the impact of vitamin D deficiency on disease pathology and progression.…”

Section: Introductionmentioning

confidence: 99%

Serum vitamin D levels in treatment-naïve chronic hepatitis B patients

Said

Agawy

Ahmed

et al. 2017

Journal of Translational Internal Medicine

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Background and Objectives: According to the demographic health survey conducted in 2015, Egypt had 10% documented prevalence of anti-HBc positive patients aged 1-59 and 1% viremic patients amongst the population in the same age group, with a domination of genotype D. Several studies claimed the possible role of vitamin D deficiency in hepatitis B virus (HBV) replication and disease progression. Patients and Methods: Serum vitamin D levels [25(OH) D3] were assessed in 96 HBeAg negative non-cirrhotic chronic HBV patients and 25 healthy subjects classified as following: Group I: 48 chronic HBV patients with persistently normal ALT levels and HBV DNA level < 2000 IU/mL for ≥ 6 months; Group II: 48 chronic HBV patients with CHB with persistently elevated ALT and HBV DNA level ≥ 2000 IU/mL for ≥ 6 months; and Group III: 25 apparently healthy subjects with normal liver enzymes and negative hepatitis viral markers were taken as the control group. Results: Vitamin D was much more deficient in group II than in group I and group III being 11.55 ± 3.97 ng/mL, 15.03 ± 3.45, 27.00 ± 6.76 ng/mL (P < 0.001), respectively, and a strong negative correlation was observed between vitamin D levels and HBV DNA levels (P = 0.043) in groups I and II. Conclusion: The current study showed high HBV DNA replication in patients with vitamin D deficiency suggesting the antimicrobial immunomodulatory role of vitamin D.

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“…The identification of the role of receptor polymorphism in chronic hepatitis B makes us think that low serum levels of 25(OH)D may have an effect on the course of chronic hepatitis B (14). Thus, in the study by Demir et al (15), 25(OH)D levels were significantly lower in the case group than in the immune and healthy control groups. Similarly, we found that chronic HBV patients had lower levels of 25(OH) D than the control group.…”

Section: Discussionmentioning

confidence: 98%