Vitamin D levels in patients with recurrent aphthous stomatitis

Öztekin, Aynure; Öztekin, Coşkun

doi:10.1186/s12903-018-0653-9

Cited by 22 publications

(34 citation statements)

References 27 publications

(26 reference statements)

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“…Khabbazi et al 16 reported that vitamin D levels were significantly lower in study group than control group. Similarly, Oztekin and Oztekin 2 found decreased levels in the serum of patients with recurrent aphthous stomatitis compared to healthy control patients. Also, Bahramian et al 17 reported that the serum levels of vitamin D in patients with recurrent aphthous stomatitis were significantly less than that in healthy individuals.…”

Section: Discussionmentioning

confidence: 81%

“…We also found no correlation between vitamin D status and the severity of the disease. To the best of our knowledge, there are only a few studies conducted in adult population on the relationship between recurrent aphthous stomatitis and vitamin D. 2,5,16 But the results are controversial. Krawiecka et al 5 conducted a study in Poland and found no significant difference between patients with recurrent aphthous stomatitis and healthy individuals in terms of vitamin D levels.…”

Section: Discussionmentioning

confidence: 99%

“…1 These idiopathic lesions are characterized by recurrent painful attacks. 2 The condition is chronic and usually self-limiting in immunocompetent patients. Etiology remains unclear, but local trauma, emotional stress, allergy, toxin exposure, poor oral hygiene, vitamin deficiency, and alterations in the oral flora are defined as risk factors.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Levels in Children With Recurrent Aphthous Stomatitis

Nalbantoğlu

2019

Ear Nose Throat J

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Background: Recurrent aphthous stomatitis is one of the most prevalent oral mucosa diseases and the etiology is unclear. As a potent anti-inflammatory and immunomodulating agent, vitamin D can significantly affect oral cavity homeostasis. However, to the best of our knowledge, no study has been conducted in pediatric population on the potential role of vitamin D in recurrent aphthous stomatitis to date. The aim of the present study is to determine the vitamin D status in recurrent aphthous stomatitis in children. Methods: This study is conducted retrospectively. Seventy-two patients with minor recurrent aphthous stomatitis and 70 age-matched healthy controls included in the study. 25-Hydroxyvitamin D levels were measured in all patients using enzyme immunoassay. Results: Serum vitamin D levels were 16.4 (8.6) ng/mL in patient group and 23.1 (11.5) ng/mL in healthy controls. There was a statistically significant difference between the groups in terms of serum vitamin D levels ( P = .002). There was no significant correlation between serum vitamin D levels and the severity of the recurrent aphthous stomatitis ( r = 0.54, P = .76). Conclusions: Our study showed a significant difference in vitamin D levels between patients with recurrent aphthous stomatitis and the healthy control group. We also found no correlation between vitamin D status and the severity of the disease.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D Levels in Children With Recurrent Aphthous Stomatitis

Nalbantoğlu

2019

Ear Nose Throat J

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“…In this preliminary study, we aimed to better understand periodontopathic patient evaluation, especially from a perspective of inflammatory markers and vitamin D assessment, through an ELISA assay. The evaluation of vitamin D levels is commonly performed in serum, and only a few studies have assessed its levels in gingival crevicular fluid (GCF), which is considered as serum exudate [30,31]. Both blood and GCF sampling have relative invasiveness linked to their withdrawal method.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Salivary Cytokines and Vitamin D Levels in Periodontopathic Patients

Costantini

Sinjari

Piscopo

et al. 2020

IJMS

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Periodontal disease (PD) is an inflammatory condition of the tissues supporting the teeth, which is widespread among the adult population. Evidence shows a relationship between PD and vitamin D levels, which is involved in the regulation of bone metabolism, mineral homeostasis, and inflammatory response. This study aimed to perform a simultaneous evaluation of inflammatory mediators and vitamin D levels in saliva in periodontopathic patients to better understand their role in periodontal disease. In this observational study, clinical periodontal parameter examination was performed for each patient. Moreover, the saliva levels of 25(OH)D3, TGFβ, IL-35, IL-17A, and MMP9 were evaluated using an ELISA assay. An increase in TGFβ, IL-35, MMP9, and IL-17A salivary levels and a reduction in 25(OH)D3 levels were observed in periodontopathic patients with respect to the healthy controls. The present study revealed significant positive correlation between cytokines and highly negative correlation between 25(OH)D3 and salivary cytokine levels. Further studies are needed to better understand if salivary cytokines and vitamin D evaluation may represent a new approach for detection and prevention of progressive diseases, such as PD.

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“…The lesions usually heal spontaneously within 7-10 days without scarring [2][3][4]. Most affected patients usually develop more than one ulcer in each episode, and experience several episodes annually [2] Despite the high prevalence, and the extensive research on RAS, its etiology is still unclear; instead, a number of predisposing factors have been proposed including, but not limited to, genetic predilection, hematologic factors, immunologic defects, vitamins deficiencies, emotional stress, and local trauma [2,3,[5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

et al. 2020

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Background: Recurrent aphthous stomatitis (RAS) is a highly prevalent oral mucosal disease. The management of RAS is quite challenging, and as yet, there is no definitive cure. The present systematic review and meta-analysis assessed the efficacy of a single application of topical doxycycline for the management of RAS. Methods: A comprehensive online search of PubMed, Scopus, Embase, and Web of Science databases was conducted to identify all relevant studies published up to March 31, 2019. All randomized clinical trials that assessed the efficacy of a single application of topical doxycycline in the management of RAS were included. Primary outcome measures were pain scores and/or healing time, while secondary outcomes included the associated side effects. RevMan 5.3 software was used for data analysis. Results: Five clinical trials fulfilled the eligibility criteria, three of which were included in the meta-analysis. All of the included studies found doxycycline effective in alleviating signs and symptoms of RAS. The results of the pooled 3 studies revealed a statistically significant decrease in the healing time in favor of the doxycycline group as compared to the control groups (I 2 = 51%; MD:-1.77, 95% CI: − 2.11, − 1.42, P <0.00001); however, the results showed no significant differences between doxycycline and control groups with regard to pain reduction (I 2 = 96%; MD:-1.28, 95% CI: − 2.83, 0.27; P = 0.11). Conclusion: Although still inconclusive, the available evidence suggests that a single application of topical doxycycline might be effective for reducing signs and symptoms of RAS. However, owing to the limited number of the included studies, further well-designed clinical trials with adequate sample sizes are required to discern the clinical efficacy of topical doxycycline in patients with RAS.

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Vitamin D levels in patients with recurrent aphthous stomatitis

Cited by 22 publications

References 27 publications

Vitamin D Levels in Children With Recurrent Aphthous Stomatitis

Vitamin D Levels in Children With Recurrent Aphthous Stomatitis

Evaluation of Salivary Cytokines and Vitamin D Levels in Periodontopathic Patients

Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

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