Vitamin-D-Mangel in der Schweizer Sonnenstube?

Quarenghi, Massimo; Aubry, Emilie; Aeberhard, Carla; Ossola, Nicola; Marone, Claudio; Stanga, Zeno

doi:10.1024/1661-8157/a002836

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…An adequate supply of vitamin D can hardly be achieved with a usual diet and under normal exposition to sun light in temperate latitudes. Vitamin D deficiency occurs frequently, especially during winter months [ 1 , 2 ] and year around in elderly people who can only produce a reduced amount of vitamin D in their skin [ 3 ]. Other risk factors include dark skin (since melanin impairs the effect of UV-B radiation), overweight (because vitamin D is trapped in fatty tissue), lack of exercise, and cultural or religious dress codes (due to underexposure of the skin to sunlight) [ 4 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial

Rothen

Rutishauser

Walter

et al. 2020

BMC Pharmacol Toxicol

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Background: To assess adherence to and preference for vitamin D substitution with different pharmaceutical forms and frequencies of administration. Methods: A focus group of stakeholders aimed at preparing the design of an interventional, randomized, crossover study with 2 × 2 groups obtaining monthly or weekly vitamin D products in liquid or solid form for 3 months each. Dosage corresponds to cumulated amount of recommended 800 IU daily (5.600 IU weekly / 24.000 IU monthly). Main inclusion criteria were a vitamin D serum value < 50 nmol/l and age ≥ 18 years. Primary endpoint was adherence, secondary endpoints were preferences and vitamin D serum levels. Results: The focus group reached consensus for preference of a monthly administration of solid forms to adults. Full datasets were obtained from 97 participants. Adherence was significantly higher with monthly (79.5-100.0%) than weekly (66.4-98.1%) administration. Vitamin D levels increased significantly (p < 0.001) in all participants. An optimal value of > 75 nmol/l was achieved by 32% after 3 months and by 50% after 6 months. Preferred formulation was solid form (tablets, capsules) for 71% of participants, and preferred dosage frequency was monthly for 39% of participants. Conclusions: Monthly oral vitamin D in solid form lead to the highest adherence, and is preferred by the participants. However, only one third of study participants achieved values in the optimal range of > 75 nmol/l cholecalciferol using weekly or monthly administration providing an average daily cholecalciferol dose of 800 IU.

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Section: Introductionmentioning

confidence: 99%

Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial

Rothen

Rutishauser

Walter

et al. 2020

BMC Pharmacol Toxicol

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Renal insufficiency and magnesium deficiency correlate with a decreased formation of biologically active cholecalciferol: a retrospective observational study

et al. 2022

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Vitamin-D-Status bei Mitarbeitenden eines universitären Schweizer Geriatriespitals

Härdi

Reinhard

Conzelmann

et al. 2018

Praxis

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Vitamin D Level in Employees of a Swiss University Geriatric Hospital Abstract. Vitamin D plays an important role in health. The aim of this study was to determine the vitamin D level in hospital employees from different age, sex and occupational groups. 281 employees took part in the investigation. Vitamin D (25-OH) was determined by serum sample analysis, the mean value was 59.5 nmol/l. 43.1 % of participants showed a vitamin D deficiency (<50 nmol/l). Low vitamin D levels significantly correlated with increased BMI. Women, physically active employees and those in occupations with medical content had significantly higher vitamin D levels. Sports activity and substitution were independent predictors of vitamin D level. The study illustrated that increased sun exposure and/or vitamin D supplementation are needed.

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Vitamin-D-Mangel in der Schweizer Sonnenstube?

Cited by 4 publications

References 17 publications

Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial

Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial

Renal insufficiency and magnesium deficiency correlate with a decreased formation of biologically active cholecalciferol: a retrospective observational study

Vitamin-D-Status bei Mitarbeitenden eines universitären Schweizer Geriatriespitals

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