Vitamin-D measurement in patients with adolescent idiopathic scoliosis

Balioğlu, Mehmet Bülent; Aydin, Canan Gönen; Kargın, Deniz; Albayrak, Akif; Atıcı, Yunus; Taş, Süleyman Kasım; Kaygusuz, Mehmet Akif

doi:10.1097/bpb.0000000000000320

Cited by 50 publications

(86 citation statements)

References 27 publications

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“…Some studies noticed a possible association between vitamin D levels and scoliosis [2,52]. Balioglu et al found lower vitamin D levels and a positive correlation between vitamin D levels and calcium levels [53]. In our research all patients had a vitamin D deficiency, although the calcium level was normal.…”

Section: Discussionsupporting

confidence: 51%

Assessment of Static Plantar Pressure, Stabilometry, Vitamin D and Bone Mineral Density in Female Adolescents with Moderate Idiopathic Scoliosis

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et al. 2020

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(1) Background: Adolescent idiopathic scoliosis (AIS) can be associated with vitamin D deficiency and osteopenia. Plantar pressure and stabilometry offer important information about posture. The objectives of our study were to compare static plantar pressure and stabilometric parameters, serum 25-OH-vitamin D3 and calcium levels, and bone mineral densitometry expressed as z-score in patients with moderate AIS and healthy subjects. (2) Methods: 32 female adolescents (idiopathic S shaped moderate scoliosis, main lumbar curve) and 32 gender and age-matched controls performed: static plantar pressure, stabilometry, serum 25-OH-vitamin D3 and calcium levels, and dual X-ray absorptiometry scans of the spine. (3) Results: In scoliosis patients, significant differences were recorded between right and left foot for total foot, first and fifth metatarsal, and heel loadings. Stabilometry showed a poorer postural control when compared to healthy subjects (p < 0.001). Patients had significantly lower vitamin D, calcium levels, and z-scores. Lumbar Cobb angle was significantly correlated with the z-score (r = −0.39, p = 0.02), with right foot fifth metatarsal load (r = −0.35, p = 0.04), center of pressure CoPx (r = −0.42, p = 0.01), CoP displacement (r = 0.35, p = 0.04) and 90% confidence ellipse area (r = −0.38, p = 0.03). (4) Conclusions: In our study including female adolescents with idiopathic S shaped moderate scoliosis, plantar pressure and stabilometric parameters were influenced by the main scoliotic curve.

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Section: Discussionsupporting

confidence: 51%

Assessment of Static Plantar Pressure, Stabilometry, Vitamin D and Bone Mineral Density in Female Adolescents with Moderate Idiopathic Scoliosis

Căţan

Cerbu

Amăricăi

et al. 2020

IJERPH

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“…No relationship was observed between vitamin D levels and Cobb angle in this study, which contradicts the single study found in the literature that correlated the two variables and showed an inverse relationship 12 . Furthermore, no relationship was found between 25-OHD levels and quality of life assessment.…”

Section: Discussioncontrasting

confidence: 99%

“…Recent studies indicate an interaction between 25-OHD deficiency and development of AIS, 11 , 12 which was corroborated in our study: almost all of the patients (97%) had lower 25-OHD levels than expected. Considering the small number of studies suggesting a correlation between 25-OHD and AIS, further studies are needed to support this hypothesis and to the reasons behind this variation.…”

Section: Discussionsupporting

confidence: 91%

Role of Different Hormones in the Pathogenesis and Severity of Adolescent Idiopathic Scoliosis

et al. 2017

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Objective: To evaluate the hormonal profile of patients with adolescent idiopathic scoliosis (AIS) and its relationship to the severity of the curvature and quality of life . Method: Patients with scoliosis (Cobb angle above 10°), of both genders, diagnosed after 10 years of age were included, excluding those who presented other condition that could lead to scoliosis. Serum levels of 25-hydroxyvitamin D (25-OHD), cortisol and gastrin were correlated with Cobb angle and quality of life, measured by the SRS-30 questionnaire . Results: The levels of 25-OHD decreased in 97% of patients. There was an inverse relationship between gastrin levels and quality of life (p = 0.016). Moreover, there was an inverse correlation between the value of Cobb angle and quality of life (p = 0.036). There were no changes in cortisol levels. There was no correlation between Cobb angle and any of the hormones measured . Conclusion: The patients had levels of 25-OHD diminished, strengthening the hypothesis of its involvement in the development of AIS. This study also suggests that increased gastrin levels may be associated with a worse quality of life in patients with AIS. Level of Evidence II, Diagnostic Study.

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“…As higher levels of vitamin D correlate with greater bone mineral density, several researchers have questioned the role of vitamin D in AIS. Furthermore, recent studies have shown a relationship between gene polymorphisms of vitamin D receptors (VDRs) and low bone mineral density [37]. Suh et al reported that the VDR BsmI polymorphism is associated with low bone mineral density at the lumbar spine (LSBMD) in girls with AIS [38].…”

Section: Vitamin Dmentioning

confidence: 99%

Current concepts in the diagnosis and management of adolescent idiopathic scoliosis

2020

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Background Adolescent Idiopathic Scoliosis (AIS) is a complex 3D structural disorder of the spine that has a significant impact on a person's physical and emotionalstatus. Thus, efforts have been made to identify the cause of the curvature and improve management outcomes. Aim This comprehensive review looks at the relevant literature surrounding the possible aetio-pathogenesis of AIS, its clinical features, investigations, surgicalmanagement options, and reported surgical outcomes in anterior spinal fusion, posterior spinal fusion or combined approach in the treatment of AIS.

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Vitamin-D measurement in patients with adolescent idiopathic scoliosis

Cited by 50 publications

References 27 publications

Assessment of Static Plantar Pressure, Stabilometry, Vitamin D and Bone Mineral Density in Female Adolescents with Moderate Idiopathic Scoliosis

Assessment of Static Plantar Pressure, Stabilometry, Vitamin D and Bone Mineral Density in Female Adolescents with Moderate Idiopathic Scoliosis

Role of Different Hormones in the Pathogenesis and Severity of Adolescent Idiopathic Scoliosis

Current concepts in the diagnosis and management of adolescent idiopathic scoliosis

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