Vitamin D modulation and microRNAs in gastric cancer: prognostic and therapeutic role

Martín, Elena Gallardo; Castiñeiras, A. Cousillas

doi:10.21037/tcr-20-2813

Cited by 6 publications

(6 citation statements)

References 151 publications

(219 reference statements)

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“…Moreover, a similar expression gene pattern was found between 25(OH)D 3 and 1α,25(OH) 2 D 3 either in the transcriptome of PBMCs and LNCaP [39,40,57]. Recently, it has been demonstrated that 1,25(OH) 2 D 3 exerts regulatory effects on microRNA expression and long non-coding RNAs, potentially serving as a potential anticancer mechanism [103,104]. In this regard, no evidence has been established for the 25(OH)D 3 -induced regulation of these classes of non-coding RNA so far.…”

Section: Discussionmentioning

confidence: 56%

Calcifediol: Mechanisms of Action

Donati,

Palmini,

Aurilia

et al. 2023

Nutrients

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Due to its essential role in calcium and phosphate homeostasis, the secosteroid hormone calcitriol has received growing attention over the last few years. Calcitriol, like other steroid hormones, may function through both genomic and non-genomic mechanisms. In the traditional function, the interaction between the biologically active form of vitamin D and the vitamin D receptor (VDR) affects the transcription of thousands of genes by binding to repeated sequences present in their promoter region, named vitamin D-responsive elements (VDREs). Non-transcriptional effects, on the other hand, occur quickly and are unaffected by inhibitors of transcription and protein synthesis. Recently, calcifediol, the immediate precursor metabolite of calcitriol, has also been shown to bind to the VDR with weaker affinity than calcitriol, thus exerting gene-regulatory properties. Moreover, calcifediol may also trigger rapid non-genomic responses through its interaction with specific membrane vitamin D receptors. Membrane-associated VDR (mVDR) and protein disulfide isomerase family A member 3 (Pdia3) are the best-studied candidates for mediating these rapid responses to vitamin D metabolites. This paper provides an overview of the calcifediol-related mechanisms of action, which may help to better understand the vitamin D endocrine system and to identify new therapeutic targets that could be important for treating diseases closely associated with vitamin D deficiency.

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Section: Discussionmentioning

confidence: 56%

Calcifediol: Mechanisms of Action

Donati,

Palmini,

Aurilia

et al. 2023

Nutrients

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“…Vitamin D may modulate the expression of some miRNAs that are deregulated in gastric cancer cells. In this mechanism, vitamin D reduces chemoresistance at the cellular level [36]. Our review found that patients with gastric cancer have vitamin D deficiency, with reported rates ranging from the initial 36.67% of patients [15] up to 89% [21].…”

Section: Discussionmentioning

confidence: 84%

“…In patients with gastric cancer, it was also the vitamin D metabolite investigated that mattered, as demonstrated by Rino Y et al al, who found that although 1,25(OH) 2 D may be normal in gastric patients, the level of the most active metabolite, 25(OH)D, may remain below the normal range in a significant number of them (31.8%) [24]. However, there is still no single study that would support with strong evidence that vitamin D supplementation could result in a decrease in gastric cancer incidence rate neither in the general population nor in relapsed patients [36], and the deficiency reported initially in gastric cancer patients remains consistent with the general global population deficiency, estimated at 37.3% (circulating concentrations of 25(OH)D below 20 ng/mL) [37].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D—The Nutritional Status of Post-Gastrectomy Gastric Cancer Patients—Systematic Review

et al. 2022

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Gastric cancer is a malignant neoplasm of the gastrointestinal tract, with one of the standard treatment methods remaining gastrectomy. The authors conducted a systemic review of the Medline and Embase databases concerning the serum vitamin D level in post-gastrectomy gastric cancer patients, regarding all articles published until 22 May 2022 according to the PRISMA guidelines. 18 studies with a total number of 908 gastric cancer survivors were included in the analysis. The initial rate of vitamin D deficiency in gastric cancer patients undergoing gastrectomy appears to be similar to the global population deficiency. In post-gastrectomy survivors, the level of 25(OH)D may remain stable or decrease, while the level of 1, 25(OH)2D remains normal. Supplementation with vitamin D results in an improvement in its serum concentration and positively affects bone mineral density, which is gradually reduced in post-gastrectomy survivors. Combining vitamin D supplementation with calcium and bisphosphonates enables us to obtain better results than vitamin D and calcium only. The type of surgery influences the level of serum vitamin D and its metabolites, with total or partial gastrectomy and maintenance of the duodenal food passage remaining the most important factors. There is a strong need for randomized, controlled trials that would investigate this matter in the future.

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“…It regulated gene expression by combining with the complementary site of 3′UTR to destroy its transcriptional stability [ 34 , 35 ]. Its expression regulated the expression of a variety of genes, which was crucial to the occurrence and development of gastric cancer [ 36 , 37 ]. In previous studies, miR-379-5p was overexpressed in most tumors.…”

Section: Discussionmentioning

confidence: 99%

GRB10 is a novel factor associated with gastric cancer proliferation and prognosis

Ren

Wang

Ren

et al. 2023

Aging

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GRB10 and its family members GRB7 and GRB14 were important adaptor proteins. They regulated many cellular functions by interacting with various tyrosine kinase receptors and other phosphorus-containing amino acid proteins. More and more studies have shown that the abnormal expression of GRB10 is closely related to the occurrence and development of cancer. In our current research, expression data for 33 cancers from the TCGA database was downloaded for analysis. It was found that GRB10 was up-regulated in cholangiocarcinoma, colon adenocarcinoma, head and neck squamous carcinoma, renal chromophobe, clear renal carcinoma, hepatocellular carcinoma, lung adenocarcinoma, lung squamous carcinoma, gastric adenocarcinoma and thyroid carcinoma. Especially in gastric cancer, the high GRB10 expression was closely associated with poorer overall survival. Further research showed that the knockdown of GRB10 inhibited proliferation and migration ability in gastric cancer. Also, there was a potential binding site for miR-379-5p on the 3′UTR of GRB10. Overexpression of miR-379-5p in gastric cancer cells reduced GRB10-regulated gastric cancer proliferation and migration capacity. In addition, we found that tumor growth was slower in a mice xenograft model with knock down of GRB10 expression. These findings suggested that miR-379-5p suppresses gastric cancer development by downregulating GRB10 expression. Therefore, miR-379-5p and GRB10 were expected to be potential targets for the treatment of gastric cancer.

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Vitamin D modulation and microRNAs in gastric cancer: prognostic and therapeutic role

Cited by 6 publications

References 151 publications

Calcifediol: Mechanisms of Action

Calcifediol: Mechanisms of Action

Vitamin D—The Nutritional Status of Post-Gastrectomy Gastric Cancer Patients—Systematic Review

GRB10 is a novel factor associated with gastric cancer proliferation and prognosis

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