Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats

Şahin, Sevim; Gürgen, Seren Gülşen; Yazar, Uğur; İnce, İmran; Kamaşak, Tülay; Arslan, Elif Acar; Durgut, Betül Diler; Dilber, Beril; Cansu, Ali

doi:10.1016/j.eplepsyres.2018.12.005

Cited by 34 publications

(17 citation statements)

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“…Finally, vitamin D use in rodent cortical neurons protected against glutamate excitotoxicity and kainic acid [89,91] and high-dosing improved motor performance and grip endurance in G93A mice [89,92]. Clinically, vitamin D3 reduced the decline in ALSFRS-R score [92].…”

Section: Alternative Drugs Compounds and Antibiotics May Help Alsmentioning

confidence: 97%

“…Therefore, further investigation is required to determine the exact molecular targets for H 2 and its precise mechanisms of action. Nevertheless, hydrogen-rich saline, for example, significantly suppressed reactive oxygen and nitrogen species (ROS, RNS) production, microglial and glial activation and inhibited the release of mitochondrial apoptogenic factors [89]. Subsequently, hydrogen was shown to suppress 3-nitrotyrosine and activation of caspase-3, as well as decrease protein carbonyl levels and the formation of damaging peroxynitrite and malondialdehyde [90].…”

Section: Alternative Drugs Compounds and Antibiotics May Help Alsmentioning

confidence: 99%

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The Role of the Microbiota–Gut–Brain Axis and Antibiotics in ALS and Neurodegenerative Diseases

et al. 2020

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The human gut hosts a wide and diverse ecosystem of microorganisms termed the microbiota, which line the walls of the digestive tract and colon where they co-metabolize digestible and indigestible food to contribute a plethora of biochemical compounds with diverse biological functions. The influence gut microbes have on neurological processes is largely yet unexplored. However, recent data regarding the so-called leaky gut, leaky brain syndrome suggests a potential link between the gut microbiota, inflammation and host co-metabolism that may affect neuropathology both locally and distally from sites where microorganisms are found. The focus of this manuscript is to draw connection between the microbiota–gut–brain (MGB) axis, antibiotics and the use of “BUGS AS DRUGS” for neurodegenerative diseases, their treatment, diagnoses and management and to compare the effect of current and past pharmaceuticals and antibiotics for alternative mechanisms of action for brain and neuronal disorders, such as Alzheimer disease (AD), Amyotrophic Lateral Sclerosis (ALS), mood disorders, schizophrenia, autism spectrum disorders and others. It is a paradigm shift to suggest these diseases can be largely affected by unknown aspects of the microbiota. Therefore, a future exists for applying microbial, chemobiotic and chemotherapeutic approaches to enhance translational and personalized medical outcomes. Microbial modifying applications, such as CRISPR technology and recombinant DNA technology, among others, echo a theme in shifting paradigms, which involve the gut microbiota (GM) and mycobiota and will lead to potential gut-driven treatments for refractory neurologic diseases.

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Section: Alternative Drugs Compounds and Antibiotics May Help Alsmentioning

confidence: 97%

Section: Alternative Drugs Compounds and Antibiotics May Help Alsmentioning

confidence: 99%

The Role of the Microbiota–Gut–Brain Axis and Antibiotics in ALS and Neurodegenerative Diseases

et al. 2020

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“…Growing evidence suggests that vitamin D3 has a protective effect on regulating apoptotic factors in many different studies. Şahin et al (2019) reported the neuroprotective effects of vitamin D on hippocampal apoptosis induced by pentylenetetrazol and kainic acid in rats. It has also shown that vitamin D receptors (VDRs) express in the ovaries (theca cells and granulosa cells), endometrium, and placenta (Merhi, Doswell, Krebs, & Cipolla, 2014; Thomson, Spedding, & Buckley, 2012).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D3 affects mitochondrial biogenesis through mitogen‐activated protein kinase in polycystic ovary syndrome mouse model

Safaei

Bakhshalizadeh

Nasr‐Esfahani

et al. 2020

Journal Cellular Physiology

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Polycystic ovarian syndrome (PCOS) is a disorder characterized by oligomenorrhea, anovulation, and hyperandrogenism. Altered mitochondrial biogenesis can result in hyperandrogenism. The goal of this study was to examine the effect of vitamin D3 on mitochondrial biogenesis of the granulosa cells in the PCOSinduced mouse model. Vitamin D3 applies its effect via the mitogen-activated pathway kinase-extracellular signal-regulated kinases (MAPK-ERK1/2) pathway. The PCOS mouse model was induced by the injection of dehydroepiandrosterone (DHEA). Isolated granulosa cells were subsequently treated with vitamin D3, MAPK activator, and MAPK inhibitor. Gene expression levels were measured using real-time polymerase chain reaction. MAPK proteins were investigated by western blot analysis. We also determined reactive oxygen species (ROS) levels with 2′, 7′-dichlorofluorescein diacetate. Mitochondrial membrane potential (mtMP) was also measured by TMJC1. Mitochondrial biogenesis (peroxisome proliferator-activated receptor gamma coactivator 1-α and nuclear respiratory factor), antioxidant (superoxide dismutase, glutathione peroxidase, and catalase), and antiapoptotic (B-cell lymphoma-2) genes were upregulated in the PCOS mice that treated with vitamin D3 compared with the PCOS mice without any treatment. Vitamin D3 and MAPK activator-treated groups also reduced ROS levels compared with the nontreated PCOS group. In summary, vitamin D3 and MAPK activator increased the levels of mitochondrial biogenesis, MAPK pathway, and mtMP markers, while concomitantly decreased ROS levels in granulosa cells of the PCOS-induced mice. This study suggests that vitamin D3 may improve mitochondrial biogenesis through stimulation of the MAPK pathway in cultured granulosa cells of DHEA-induced PCOS mice which yet to be investigated. K E Y W O R D S granulosa cell, MAPK-ERK1/2 pathway, mitochondrial biogenesis, polycystic ovary syndrome, vitamin D3population. The optimal dose of vitamin D3 and the duration of the treatment for clinical trials would be a step forward towards PCOS treatment in women.

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“…In mammals, chronic treatment with vitamin D increases seizure threshold 23 and has neuroprotective effects from induced seizures. 24 Thus, although there is not yet clear data supporting that supplementation of vitamin D in adult patients with epilepsy leads to major seizure reduction, 25 these data are supportive for maintaining optimal levels of vitamin D for both possible general seizure control and the important bone health benefits.…”

Section: Discussionmentioning

confidence: 99%

Bone Health Screening Practices Among Neurologists in Patients on Antiepileptic Drugs: A Quality Improvement Project

Patel

Schomer

et al. 2020

Pediatric Neurology

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Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats

Cited by 34 publications

References 50 publications

The Role of the Microbiota–Gut–Brain Axis and Antibiotics in ALS and Neurodegenerative Diseases

The Role of the Microbiota–Gut–Brain Axis and Antibiotics in ALS and Neurodegenerative Diseases

Vitamin D3 affects mitochondrial biogenesis through mitogen‐activated protein kinase in polycystic ovary syndrome mouse model

Bone Health Screening Practices Among Neurologists in Patients on Antiepileptic Drugs: A Quality Improvement Project

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