Vitamin D Receptor Activation Reduces Angiotensin-II–Induced Dissecting Abdominal Aortic Aneurysm in Apolipoprotein E–Knockout Mice

Martorell, Sara; Hueso, Luisa; González-Navarro, Herminia; Collado, Aida; Sanz, María-Jesús; Piqueras, Laura

doi:10.1161/atvbaha.116.307530

Cited by 61 publications

(50 citation statements)

References 75 publications

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“…Doses for lixisenatide and liraglutide were chosen based on the previously reported optimal doses obtained from pharmacokinetic and drug-clearance studies in rodents described for lixisenatide [11,15,16] and liraglutide [12,[17][18][19]. Blood pressure was measured in conscious mice using a non-invasive tail-cuff system (LE5002 Pressure Meter; Panlab, Barcelona, Spain) as previously described [20].…”

Section: Methodsmentioning

confidence: 99%

The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype

et al. 2017

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Lixisenatide decreases atheroma plaque size and instability in Apoe Irs2 mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation. This study identifies a critical role for this drug in macrophage polarisation inside plaques and provides experimental evidence supporting a novel mechanism of action for GLP-1 analogues in the reduction of cardiovascular risk associated with insulin resistance.

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Section: Methodsmentioning

confidence: 99%

The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype

et al. 2017

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“…Mice with endothelial-specific deletion of the VDR exhibit reduced eNOS expression, impaired endotheliumdependent vasorelaxation, and an augmented pressor effect of angiotensin II [137]. Furthermore, vitamin D can exert powerful immunomodulatory actions to modify the immune response to injury during various diseases, including atherosclerosis [64,138], cancer [25], asthma [139], and stroke [50]. In particular, vitamin D can attenuate inflammatory responses and promote protein homeostasis via modulating the NF-κB and unfolded protein response (UPR) pathways, respectively [140,141].…”

Section: Vitamin D Deficiency and Its Impact On Cerebrovascular Diseasesmentioning

confidence: 99%

Vitamin D Deficiency and the Risk of Cerebrovascular Disease

Kim

Perrelli

Ragni³

et al. 2020

Antioxidants

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Vitamin D deficiency has been clearly linked to major chronic diseases associated with oxidative stress, inflammation, and aging, including cardiovascular and neurodegenerative diseases, diabetes, and cancer. In particular, the cardiovascular system appears to be highly sensitive to vitamin D deficiency, as this may result in endothelial dysfunction and vascular defects via multiple mechanisms. Accordingly, recent research developments have led to the proposal that pharmacological interventions targeting either vitamin D deficiency or its key downstream effects, including defective autophagy and abnormal pro-oxidant and pro-inflammatory responses, may be able to limit the onset and severity of major cerebrovascular diseases, such as stroke and cerebrovascular malformations. Here we review the available evidence supporting the role of vitamin D in preventing or limiting the development of these cerebrovascular diseases, which are leading causes of disability and death all over the world.

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“…Reduction in AAA dissection, induced by Angiotensin-II in apoE −/− mice, by VDR activation with oral vitamin D suggests the potential therapeutic role of vitamin D to decrease the AAA progression [115]. The reduction in the progression of AAA was attributed to decrease in many parameters, including macrophage infiltration, neo-vessel formation, MMP-2 and MMP-9 activation, chemokines (CCL2, CCL5, CXCL1) expression, and extracellular signal–regulated kinases 1/2, p38 mitogen-activated protein kinase, and NF-κB activity (Figure 3).…”

Section: Vascular Diseasementioning

confidence: 99%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

122

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Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.

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Vitamin D Receptor Activation Reduces Angiotensin-II–Induced Dissecting Abdominal Aortic Aneurysm in Apolipoprotein E–Knockout Mice

Abstract: VDR activation reduces dissecting AAA formation induced by Ang-II in apoE(-/-) mice and may constitute a novel therapeutic strategy to prevent AAA progression.

Cited by 61 publications

References 75 publications

The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype

The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype

Vitamin D Deficiency and the Risk of Cerebrovascular Disease

Role of Vitamin D in Cardiovascular Diseases

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