Vitamin D receptor and 1α-hydroxylase are highly expressed in lungs of mice infected with H9N2 avian influenza viruses

Lian, Pengjing; Bai, Yu; Li, Jingyun; Wang, Hongyan; Niu, Xiao-Fei; Zhang, Zihui; Li, Hongru; Zhao, Lihong; Jian, Qiao

doi:10.1016/j.jsbmb.2021.105907

Cited by 2 publications

(2 citation statements)

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“…In addition, studies have shown that the virus disrupts the host's electrolyte balance or acid-base balance, leading to nutrient imbalance and death [84][85][86][87]. The levels of 1α-hydroxylase and vitamin D receptor in lung tissues of mice infected with H9N2 avian influenza virus were reportedly significantly increased, which led to the increased calcium load in the kidney [88]. Excess calcium disrupts the electrolyte balance and acid-base balance of body fluids.…”

Section: Factors Causing Gout In Poultrymentioning

confidence: 99%

A Review of Emerging Goose Astrovirus Causing Gout

Liu

Sun

Liao

2022

BioMed Research International

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In recent years, an infection in geese caused by goose astrovirus (GAstV) has repeatedly occurred in coastal areas of China and rapidly spread to inland provinces. The infection is characterized by joint and visceral gout and is fatal. The disease has caused huge economic losses to China’s goose industry. GAstV is a nonenveloped, single-stranded, positive-sense RNA virus. As it is a novel virus, there is no specific classification. Here, we review the current understanding of GAstV. The virus structure, isolation, diagnosis and detection, innate immune regulation, and transmission route are discussed. In addition, since GAstV can cause gout in goslings, the possible role of GAstV in gout formation and uric acid metabolism is discussed. We hope that this review will inform researchers to rapidly develop effective methods to prevent and treat this disease.

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