Vitamin D Receptor polymorphisms and risk of enveloped virus infection: A meta-analysis

Laplana, Marina; Royo, José Luís; Fibla, Joan

doi:10.1016/j.gene.2018.08.017

Cited by 85 publications

(79 citation statements)

References 47 publications

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“…143,144 As such, interference with VDR gene expression may influence susceptibility to RSV disease. 145,146 VDBP GC1s haplotype is thought to enhance RSV bronchiolitis in infancy and subsequent asthma development. 147 Moreover, CYP2R1 polymorphisms might be predictive of sustained HBeAg seroconversion after PegIFN therapy in chronic HBV infection.…”

Section: Genetic Polymorphismmentioning

confidence: 99%

“…In this regard, the frequency of allelic distribution of VDR‐apaI genes was reported to be significantly higher in chronic HBV patients with severe liver disease and the risk of HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) . As such, interference with VDR gene expression may influence susceptibility to RSV disease . VDBP GC1s haplotype is thought to enhance RSV bronchiolitis in infancy and subsequent asthma development .…”

Section: Introductionmentioning

confidence: 99%

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The interplay between vitamin D and viral infections

Teymoori‐Rad

Shokri

Salimi

et al. 2019

Reviews in Medical Virology

242

230

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Summary The pleiotropic role of vitamin D has been explored over the past decades and there is compelling evidence for an epidemiological association between poor vitamin D status and a variety of diseases. While the potential anti‐viral effect of vitamin D has recently been described, the underlying mechanisms by which vitamin D deficiency could contribute to viral disease development remain poorly understood. The possible interactions between viral infections and vitamin D appear to be more complex than previously thought. Recent findings indicate a complex interplay between viral infections and vitamin D, including the induction of anti‐viral state, functional immunoregulatory features, interaction with cellular and viral factors, induction of autophagy and apoptosis, and genetic and epigenetic alterations. While crosstalk between vitamin D and intracellular signalling pathways may provide an essential modulatory effect on viral gene transcription, the immunomodulatory effect of vitamin D on viral infections appears to be transient. The interplay between viral infections and vitamin D remains an intriguing concept, and the global imprint that vitamin D can have on the immune signature in the context of viral infections is an area of growing interest.

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Section: Genetic Polymorphismmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The interplay between vitamin D and viral infections

Teymoori‐Rad

Shokri

Salimi

et al. 2019

Reviews in Medical Virology

242

230

View full text Add to dashboard Cite

show abstract

“…The VDR gene is located at q11‐q13 on chromosome 12. Several major VDR polymorphisms have been studied in the context of viral infection susceptibility, including Fok I (C/T, exon 2, rs2228570), Taq I (T/C, exon 9, rs731236), Bsm I in intron 8 (G/A, rs1544410), Apa I in intron 8 (A/C, rs7975232), Tru9 I in intron 8 (G/A, rs757343), rs739837 (G/T, 3′‐untranslated region [3′‐UTR]), and rs11574129 (G/A, 3′‐UTR) . Single‐nucleotide polymorphisms (SNPs) in the VDR gene have been associated with risk of acute lower respiratory tract infection in young children in Canada, which is consistent with the notion that vitamin D modulates the immune response to viral respiratory tract infections.…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71

Deng

et al. 2018

Journal of Medical Virology

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Severe hand, foot, and mouth disease (HFMD) is sometimes associated with critical complications that can cause substantial child mortality. Activity of the vitamin D receptor (VDR) may influence the outcomes of enterovirus 71 (EV71) infection. This case‐control study aimed to assess the association of single‐nucleotide polymorphisms (SNPs) in the gene encoding the VDR with the severity of EV71‐associated HFMD. We selected four VDR SNPs based on linkage disequilibrium and functional prediction, and we tested them using the SNPscan multiple SNP typing method for potential association with severity of EV71‐associated HFMD. We found a significant association in the case of rs11574129 (G vs A: odds ratio (OR), 0.3439; 95% confidence intervals (CI), 0.1778‐0.6653) and rs739837 (T vs G: OR, 0.5580; 95%CI, 0.3352‐0.9291). Our results suggest that these two SNPs may influence the severity of EV71‐associated HFMD.

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“…59 Association of FokI polymorphism with RSV infection emerged as significant from a recent meta-analysis. 112 Also, another SNP in the VDR gene (rs2228570) was reported to be associated with progression to death from acute viral bronchiolitis especially RSV-associated bronchiolitis. 28 According to the Stoppelenburg et al study, the predisposition of VDR SNPs to severe RSV bronchiolitis may be due to the impaired ability of vitamin D to modulate antiviral responses in airway epithelia, resulting in enhanced immunopathology and exacerbated RSV bronchiolitis.…”

Section: Effects Of Variation In Vdrmentioning

confidence: 99%

“…Importantly, Drysdale et al reported that the rs10735810 SNP is associated with increased chronic respiratory morbidity and reduced lung function in infants who had RSV infection . Association of FokI polymorphism with RSV infection emerged as significant from a recent meta‐analysis . Also, another SNP in the VDR gene (rs2228570) was reported to be associated with progression to death from acute viral bronchiolitis especially RSV‐associated bronchiolitis .…”

Section: Introductionmentioning

confidence: 99%

Disease severity in respiratory syncytial virus infection: Role of host genetic variation

Tahamtan

Askari

Bont

et al. 2019

Reviews in Medical Virology

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Summary Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis and pneumonia in the pediatric population worldwide. The immunopathology of RSV infection varies considerably and severe disease occurs only in a minority of the population. There are many factors (host, viral, and environmental) that contribute to the complicated disease phenotype. In this regard, host factors are decisive for pulmonary susceptibility to RSV infection. Host genetic diversity certainly affects the balance between control of viral replication and tissue damage during RSV infection, consequently impacting on diseases outcome. In this review, we discuss the role of host genetic variation in disease caused by RSV aiming to highlight genetic risk factors for one of the most common diseases in early childhood. Our findings clearly indicate that the response of each individual to infection is influenced by genetic diversity mainly linked to the regulation of host immune responses. Future genetic association and functional studies using more powerful and consistently reproducible approaches will likely be able to confirm, refine, and expand our developing concept of RSV disease pathogenesis.

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Vitamin D Receptor polymorphisms and risk of enveloped virus infection: A meta-analysis

Abstract: The results disclose FokI polymorphism as a relevant variant capturing the association of VDR polymorphisms with viral infection.

Cited by 85 publications

References 47 publications

The interplay between vitamin D and viral infections

The interplay between vitamin D and viral infections

Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71

Disease severity in respiratory syncytial virus infection: Role of host genetic variation

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