Vitamin D Receptor Polymorphisms and Cancer

Gandini, Sara; Gnagnarella, Patrizia; Serrano, Davide; Pasquali, Elena; Raimondi, Sara

doi:10.1007/978-1-4939-0437-2_5

Cited by 71 publications

(69 citation statements)

References 168 publications

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“…In addition, Gc polymorphisms were demonstrated on a meta-analysis for their association with skin cancer susceptibility in European (Zhaoi et al, 2014). Interestingly, a risk genotype of Gc in one cancer can be a protective genotype in other cancers (Gandini et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

Maneechay¹,

Boonpipattanapong²,

Kanngurn³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: This case-control study aimed to determine if there were any associations between the two single nucleotide polymorphisms (SNPs) in Gc, rs7041 (Asp416Glu) and rs4588 (Thr420Lys) and 3 common cancers (breast, lung and colorectal) in Thai patients. Materials and Methods: Two hundred and eighty two colorectal, 101 breast and 113 lung cancer patients were recruited from one institute during 2011-2013. The controls were age-matched volunteers who had a negative history of index cancers. In addition, vitamin D levels were compared among different genotypes in the 2 SNPs. Results: The minor allele frequencies of rs7041 (G) and rs4588 (A) were 0.32 and 0.24, respectively. Under the dominant model, the study found significant associations between minor-allele genotypes of the SNP rs7041 (TG/GG) and lung cancer (odds ratio [OR] 1.78, 95% CI 1.05-3.03). When subgroup analysis was performed according to sex and age at diagnosis, the study found that the minorallele genotypes of rs7041 (TG/GG) were significantly associated with colorectal cancer in patients whose age at diagnosis was more than 60 years (OR 1.67, 95%CI 1.06-2.61) and the minor-allele genotypes of rs4588 (CA/AA) were significantly associated with colorectal cancer in males aged 60 years or less (OR 2.34, 95%CI 1.25-4.37). When SNP combinations (rs7041-rs4588) were examined, the TT-CA combination had a significant protective

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Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

Maneechay¹,

Boonpipattanapong²,

Kanngurn³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Significant associations between VDR polymorphisms and breast (Fok1, Bsm1, Apa1), prostate (Fok1, Bsm1, Taq1), colorectal (Fok1, Bsm1, Taq1) and skin cancer (Fok1, Bsm1, Taq1) have been reported (9). For instance, the CDX2 polymorphism (SNP -rs11568820) of the VDR gene has been associated with cancer susceptibility amid varied results.…”

mentioning

confidence: 99%

“…Stratifying the data by cancer types showed a strong association between VDR CDX2 polymorphisms and an amplified risk of colorectal and ovarian cancer (10). Gandini et al analysed the association between VDR polymorphisms (Fok1, Bsm1, Taq1, Apa1, and Cdx2) and various types of cancer such as ovarian cancer, renal cell carcinoma, thyroid carcinoma, hepatocellular carcinoma (HCC), sarcoma, skin (melanoma and nonmelanoma skin cancer), bladder cancer, non-Hodgkin's lymphoma, leukaemia, oesophageal adenocarcinoma (EAC), head and neck and oral squamous cell carcinoma including 79 independent studies, for a total of 52427 cases and 62225 controls (9). The study concluded that significant associations exist between VDR polymorphisms and prostate (Fok1, Bsm1, Taq1), breast (Fok1, Bsm1, Apa1), colorectal (Fok1, Bsm1, Taq1) and skin cancer (Fok1, Bsm1, Taq1) (Figures 1 and 2).…”

mentioning

confidence: 99%

Vitamin D Receptor Polymorphism and Cancer: An Update

Rai

Abdo

Agrawal

et al. 2017

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“…Similarly, in a meta-analysis, VDR expression had no significant effect on the outcomes (Theodoratou et al 2014). However, there is also a potential importance for VDR polymorphisms in prostate cancer patients, as a number of polymorphisms have been associated with disease progression and lethality (Shui et al 2012, Gandini et al 2014.…”

Section: Vitamin D Receptor (Vdr or Nr1i1)mentioning

confidence: 95%

WOMEN IN CANCER THEMATIC REVIEW: New roles for nuclear receptors in prostate cancer

Leach

Powell

Bevan

2016

Endocrine-Related Cancer

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Prostate cancer has, for decades, been treated by inhibiting androgen signalling. This is effective in the majority of patients, but inevitably resistance develops and patients progress to life-threatening metastatic disease -hence the quest for new effective therapies for 'castrate-resistant' prostate cancer (CRPC). Studies into what pathways can drive tumour recurrence under these conditions has identified several other nuclear receptor signalling pathways as potential drivers or modulators of CRPC. The nuclear receptors constitute a large (48 members) superfamily of transcription factors sharing a common modular functional structure. Many of them are activated by the binding of small lipophilic molecules, making them potentially druggable. Even those for which no ligand exists or has yet been identified may be tractable to activity modulation by small molecules. Moreover, genomic studies have shown that in models of CRPC, other nuclear receptors can potentially drive similar transcriptional responses to the androgen receptor, while analysis of expression and sequencing databases shows disproportionately high mutation and copy number variation rates among the superfamily. Hence, the nuclear receptor superfamily is of intense interest in the drive to understand how prostate cancer recurs and how we may best treat such recurrent disease. This review aims to provide a snapshot of the current knowledge of the roles of different nuclear receptors in prostate cancer -a rapidly evolving field of research.

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Vitamin D Receptor Polymorphisms and Cancer

Cited by 71 publications

References 168 publications

Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

Vitamin D Receptor Polymorphism and Cancer: An Update

WOMEN IN CANCER THEMATIC REVIEW: New roles for nuclear receptors in prostate cancer

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