Vitamin D reduces LPS-induced cytokine release in omental adipose tissue of women but not men

Roy, Paul‐Emile; Nadeau, Mélanie; Valle, Marion; Bellmann, Kerstin; Marette, André; Tchernof, André; Gagnon, Claudia

doi:10.1016/j.steroids.2015.08.014

Cited by 14 publications

(14 citation statements)

References 42 publications

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“…Another possible explanation is the effect of vitamin D on the immune system. Vitamin D plays a key role in modulating the secretion of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) [ 29 , 30 , 31 ]. A growing body of evidence suggests the involvement of IL-1β, TNF-α, and other inflammatory cytokines in sleep regulation [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Vitamin D Levels and Sleep Disturbance in Hemodialysis Patients

et al. 2017

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Sleep disturbance is a frequent and serious complication of hemodialysis (HD). Low serum vitamin D levels have been associated with sleep quality in non-HD subjects. Our aim was to examine the possible association between serum vitamin D levels and the presence of sleep disturbance in HD patients. We recruited 141 HD patients at the HD center of the First Affiliated Hospital of Jiaxing University during 2014–2015. Serum levels of 25-hydroxyvitamin D (25(OH)D) were determined by the competitive protein-binding assay. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI). Demographic, clinical and laboratory data were recorded. Meanwhile, 117 healthy control subjects were also recruited and underwent measurement of 25(OH)D. Eighty-eight patients (62.4%) had sleep disturbance (PSQI scores ≥ 5). Patients with sleep disturbance showed lower levels of 25(OH)D as compared to those without sleep disturbance (85.6 ± 37.4 vs. 39.1 ± 29.1 nmol/L, p < 0.001). In multivariate analyses, serum levels of 25(OH)D (≤48.0 nmol/L) were independently associated with sleep disturbance in HD patients (OR 9.897, 95% CI 3.356–29.187, p < 0.001) after adjustment for possible variables. Our study demonstrates that low serum levels of vitamin D are independently associated with sleep disturbance in HD patients, but the finding needs to be confirmed in future experimental and clinical studies.

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Section: Discussionmentioning

confidence: 99%

Association between Serum Vitamin D Levels and Sleep Disturbance in Hemodialysis Patients

et al. 2017

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“…VitD regulates the adipokine secretion in adipocytes, such as adiponectin, leptin, and resistin [55]. Adiponectin is an anti-inflammatory and insulin-sensitizing hormone, which is the major adipokine secreted by adipocytes [56].…”

Section: Rs3782905 -G (C)mentioning

confidence: 99%

“…VitD promotes a lower chemokine and cytokine release by adipocytes and the chemotaxis of monocytes. In AT explants, vitD lowered the cytokine release from visceral AT (VAT) but not from SAT [48,55]. In VAT in people with obesity, there is a reduced adenosine monophosphate-activated protein kinase (AMPK) and it is closely associated with AT inflammation.…”

Section: Vitd and Inflammationmentioning

confidence: 99%

Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship

et al. 2018

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Vitamin D (vitD) deficiency is associated with a wide range of chronic diseases and conditions, including obesity, and with an increasing severity of metabolic dysregulation, such as insulin resistance, hyperlipidemia, liver disease, and hypertension, both in children and adults. However, the nature of the association between low vitD status and obesity remains unclear. This fact has motivated the scientific community to conduct genetic association analyses between 25-hydroxyvitamin D (25[OH]D)-related genes and obesity traits. In this line, the variation in the vitD receptor (VDR) gene represents the bulk of the findings. Specifically, polymorphisms in the VDR gene have been associated with obesity traits in some but not all, studies. Thus, results regarding this matter remain inconclusive. Other genes aside from VDR have also been investigated in relation to obesity-related traits. However, again, findings have been inconsistent. In general, results point to the fact that the DBP/GC gene could be an important protein-linking obesity and vitD status. On the other hand, several studies have attempted to determine the molecular mechanism of the relationship between 25(OH)-D levels and obesity. Some of these studies suggest that vitD, due to its fat-soluble characteristic, is retained by the adipose tissue and has the capacity to metabolize 25(OH)-D locally, and this can be altered during obesity. Additionally, vitD is capable of regulating the gene expression related to adipogenesis process, inflammation, oxidative stress, and metabolism in mature adipocytes. Therefore, the aim of the present review was to evaluate the association between obesity and vitD deficiency describing the main molecular mechanism of the relationship and the link with genetic factors. Key Messages: Low serum 25(OH)-D is positively associated with obesity or BMI in adults and children. Circulating vitD concentrations are, at least, partially determined by genetic factors. VitD plays an important role in the adipogenesis process and inflammation status in adipocytes and adipose tissue.

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“…In addition, more and more research regarding vitamin D has been published, especially on its immunoregulating effect, partly due to the expression of VDR on the surface of natural killer cells, antigen presenting cells, as well as B and T lymphocytes [ 13 , 14 ]. It has also been demonstrated that vitamin D plays an important role on cytokines, such as reduction of Th1 cytokines such as interferon (IFN)-γ, IL-2, and tumor necrosis factor (TNF)-ɑproduction, inhibition of pro-inflammatory cytokines such as IL-6 and IL-17, and up-regulation of anti-inflammatory cytokines such as IL-4 and IL-10 [ 15 , 16 ]. Both animal and epidemiological studies have suggested that vitamin D deficiency might predispose to some autoimmune diseases, such as SLE, systemic sclerosis (SSC), and rheumatoid arthritis (RA) [ 17 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

Altered microRNAs expression in T cells of patients with SLE involved in the lack of vitamin D

Yang

et al. 2017

Oncotarget

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Vitamin D has been recognized as a potent immunomodulator and its deficiency is common in different population groups including patients with SLE. As miRNAs regulation plays a significant role in SLE, the present study aimed to evaluate the association between vitamin D status and miRNAs levels in patients with SLE. The serum concentrations of vitamin D (25-hydroxyvitamin D) and the levels of six miRNAs in T cells from patients with SLE were measured in 42 SLE cases and 48 healthy controls. Vitamin D treatment was also performed in isolated and cultured T cells from SLE patients in different times and doses. Vitamin D insufficiency (25-hydroxyvitamin D concentration <20 ng/ml) was more common in cases than in controls. Although age and BMI were similar, cases had significantly lower concentrations of miRNA-377, miRNA-342, miRNA-10a, miRNA-374b, miRNA-125a, and miRNA-410 than controls. Furthermore, a significant positive correlation was also observed between 25-hydroxyvitamin D concentrations and measured miRNAs levels. A significant difference in observed miRNAs levels was also observed in patients with 25-hydroxyvitamin D insufficiency compared with patients with 25-hydroxyvitamin D concentration ≥20 ng/ml. And 1α,25(OH)2D3 differentially regulated miRNAs expression in dose- and time- manner in vitro. Lower expressions of miRNA-377, miRNA-342, miRNA-10a, miRNA-374b, miRNA-125a, and miRNA-410 were found in SLE patients. And severe vitamin D deficiency is associated with decreased observed miRNAs levels in SLE patients. A 25-hydroxyvitamin D concentration value <20 ng/ml is suggested as the “cut-off” for such immunological alterations in patients with SLE.

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Vitamin D reduces LPS-induced cytokine release in omental adipose tissue of women but not men

Cited by 14 publications

References 42 publications

Association between Serum Vitamin D Levels and Sleep Disturbance in Hemodialysis Patients

Association between Serum Vitamin D Levels and Sleep Disturbance in Hemodialysis Patients

Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship

Altered microRNAs expression in T cells of patients with SLE involved in the lack of vitamin D

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