Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression

Busa, Prabhakar; Huang, Nian-Cih; Kuthati, Yaswanth; Wong, Chih‐Shung

doi:10.1016/j.heliyon.2023.e15268

Cited by 4 publications

(1 citation statement)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rheumatoid arthritis [164] Multiple sclerosis [165,166] Allergic diseases [167] Chronic diseases [168] Cardiovascular disease [19,169] Cancer [170] Cell growth regulation…”

Section: Calcium Homeostasismentioning

confidence: 99%

Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 Regulators That Affect Expression and Enzymatic Activity

Vo,

Nguyen,

Kim

et al. 2023

IJMS

View full text Add to dashboard Cite

Fat-soluble vitamins (vitamin A, D, E, and K) assume a pivotal role in maintaining human homeostasis by virtue of their enzymatic functions. The daily inclusion of these vitamins is imperative to the upkeep of various physiological processes including vision, bone health, immunity, and protection against oxidative stress. Current research highlights fat-soluble vitamins as potential therapeutics for human diseases, especially cancer. Fat-soluble vitamins exert their therapeutic effects through multiple pathways, including regulation of matrix metalloproteinases’ (MMPs) expression and enzymatic activity. As MMPs have been reported to be involved in the pathology of various diseases, such as cancers, cardiovascular diseases, and neurological disorders, regulating the expression and/or activity of MMPs could be considered as a potent therapeutic strategy. Here, we summarize the properties of fat-soluble vitamins and their potential as promising candidates capable of effectively modulating MMPs through multiple pathways to treat human diseases.

show abstract

“…Rheumatoid arthritis [164] Multiple sclerosis [165,166] Allergic diseases [167] Chronic diseases [168] Cardiovascular disease [19,169] Cancer [170] Cell growth regulation…”

Section: Calcium Homeostasismentioning

confidence: 99%