Vitamin D Related Musculoskeletal System Findings

Sarıfakıoğlu, Ayşe Banu; Yalbuzdağ, Şeniz Akçay; Güzelant, Aliye Yıldırım; Afşar, Sevgi İkbali; Ustaömer, Kübra

doi:10.4274/tod.48378

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…Kronik kas-iskelet sistemi ağrıları olan hasta gruplarında ciddi anlamda vitamin D eksikliği saptanmıştır (14). Bu hastaların çoğu karşımıza kas ve iskelet sistemi deformiteleri ile gelebilmektedir (15,16). Bir literatür çalışmasında D vitamin eksikliğinin, FM'deki gibi benzer semptomlara neden olabileceğini ve bu hastaların yanlışlıkla FM tanısı aldığını öne sürmüşlerdir (17).…”

Section: Discussionunclassified

Fi̇bromi̇yalji̇ Tedavi̇si̇ Alan Hastalarda 25-Hi̇droksi̇ Vi̇tami̇n D Düzeyleri̇ni̇n Değerlendi̇ri̇lmesi̇

Düğeroğlu

2022

Kocatepe Tıp Dergisi

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OBJECTIVE: The aim of this study was to evaluate 25-hydroxy vitamin D (25(OH)D) levels in patients receiving fibromyalgia treatment.MATERIAL AND METHODS: In the study, the data of 244 patients aged 18 years and older who were diagnosed with fibromyalgia according to the ACR (American College of Rheumatologist) 2010 diagnostic criteria in our hospital between January 2018 and March 2020, and other systemic diseases were excluded, and the data of 120 patients as the control group were etrospectively reviewed. The patients who received fibromyalgia treatment and the patients in the control group were divided into three groups according to their serum 25-hydroxy vitamin D levels (deficient, insufficient and normal). It was analysed whether there was a statistically significant difference between the groups. In addition, vitamin D levels of the patient group were evaluated according to age ranges. P value less than 0.05 was considered as significant.RESULTS: Of the 244 patients diagnosed with fibromyalgia included in the study, 66.4% (n=162) were female and 33.6% (n=82) were male. The mean serum 25(OH)D level of the patient group was calculated as 16.2±12.7 ng/ml. Of the 120 patients taken as the control group, 70% (n=84) were female and 30% (n=36) were male. Mean serum 25(OH)D level of the control group was calculated as 24.6±13.1 ng/ml. When the gender and serum 25(OH)D levels of the patients in the fibromyalgia treatment group and the control group were compared statistically, a significant difference was found between the groups (p=0.017). In addition, we found the lowest serum 25 (OH) D level in the patient group between the ages of 36-50.CONCLUSIONS: High levels of vitamin D deficiency and insufficiency are observed in patients receiving fibromyalgia treatment. Therefore, adequate replacement in patients with low vitamin D levels will provide a significant decrease in musculoskeletal system symptoms and complaints.

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Section: Discussionunclassified

Fi̇bromi̇yalji̇ Tedavi̇si̇ Alan Hastalarda 25-Hi̇droksi̇ Vi̇tami̇n D Düzeyleri̇ni̇n Değerlendi̇ri̇lmesi̇

Düğeroğlu

2022

Kocatepe Tıp Dergisi

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“…[26] Diğer bir çalışmada ise Sarıfakıoğlu ve ark. [27] miyalji, artralji, bölgesel ve yaygın vücut ağrısı bulunan ancak osteoporoz/osteomalazi, endokrin patoloji ve inflamatuvar romatizmal hastalığı bulunmayan 214 hastanın verilerini retrospektif olarak incelemişlerdir. D vitamini açısından hastaların %46,7'sinin ciddi eksiklik grubunda, %31,8'inin eksiklik grubunda, %21,5'inin yetersizlik grubunda bulunduğunu bildirmişlerdir.…”

Section: Discussionunclassified

“…Bu nedenle, inatçı eklem kas ağrıları gibi yakınmaları olan hastaların D vitamini düzeylerinin de incelenmesi gerektiği sonucuna varmışlardır. [27] Deney hayvanları üzerinde yapılan bir çalışmada, D vitamininin omurilikteki prooksidan ve antioksidanları modüle ederek antinosisepsiyona neden olabileceği bildirilmiştir. [28] Bununla birlikte D vitamini-nöropatik ağrı ilişkisini açığa çıkarmaya yönelik çalışmalar çoğunlukla diyabetik nöropati ile ilgilidir.…”

Section: Discussionunclassified

Investigation of neuropathic pain in women with low vitamin D levels

Çırakoğlu¹

2022

bogazicitip

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Objectives: Besides the known metabolic effects of vitamin D, its role in modulation of pain is controversial. In our study, we aimed to investigate the possible relationship between demographic data and some biochemical values of blood who has in female patients with low vitamin D levels and neuropathic pain. Methods:The data of the patients who applied to the Physical Medicine and Rehabilitation Polyclinic between January 2017 and January 2018 were evaluated retrospectively. Seventy-nine female patients with low vitamin D levels who met the inclusion criteria were included in the study. The painDETECT pain questionnaire was used to evaluate the presence of neuropathic pain. According to this questionnaire, the patients were divided into three groups as no neuropathic pain, suspicious, and present.Results: Neuropathic pain component was detected by the painDETECT questionnaire in 15 (19%) of the female patients with low vitamin D levels. There was no statistically significant difference between neuropathic pain groups and age, education levels, number of births, body mass index as well as plasma values of vitamin D, alkaline phosphatase, parathyroid hormone, and calcium in female patients with low vitamin D levels. Conclusion:In this retrospective study, we observed similar biochemical data in patients with different degrees of neuropathic pain and low vitamin D levels. We think that it can be prospectively investigated whether vitamin D supplementation will make a difference in treatment the patients with low vitamin D levels and neuropathic pain.

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“…Kronik ve nonspesifik kas iskelet sistem ağrısı olanlarda vitamin D düşüklüğü prevalansının yüksek olduğu bildirilmiştir (10). D vitamini eksikliği karşımıza kas iskelet problemleri şeklinde çıkabilir (11,12) ve FMS'dekine benzer semptomlara yol açabilir (13).…”

Section: Bulgularunclassified

Fibromiyalji Sendromunda D Vitamin Düzeylerinin Değerlendirilmesi

Özgen

Aydoğan²,

Uygur³

et al. 2018

Osmangazi̇ Journal of Medicine

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Özet: Bu çalışmanın amacı, fibromiyalji sendromu olan hastalarda 25(OH)D düzeyini değerlendirmek ve hassas nokta sayısı ile 25(OH)D düzeyi arasındaki ilişkiyi araştırmaktı. Bu retrospektif çalışmaya, 2016-2017 yılları arasında fibromiyalji tanısı almış 61 hasta dahil edildi. Hastaların demografik verileri, 25(OH)D düzeyleri, hassas nokta sayıları değerlendirildi. Hastalar 25(OH)D düzeyleri göre; D vitamini eksikliği (<20 ng/ml), D vitamini yetersizliği (20-30 ng/ml) ve normal D vitamini düzeyi olarak (>30 ng/ml) sınıflandırıldı. Fibromiyalji tanısı olan 61 hastanın 25(OH)D düzeyleri ortalaması 18,08±11,72 idi. D vitamin düzeyleri incelendiğinde, 40 fibromiyalji hastasında D vitamini eksikliği, 14 fibromiyalji hastasında D vitamini yetersizliği olduğu saptandı. Fibromiyalji tanısı olan hastaların sadece 7'sinde (%11,48) D vitamin düzeyleri normal seviyede bulunmuştur. Hastaların 25(OH)D düzeyleri ve hassas nokta sayıları arasında anlamlı bir korelasyon gözlemlenmedi. Fibromiyaljili hastaların büyük çoğunluğunda vitamin D düzeylerinin düşük olduğu, bununla birlikte fibromiyaljili hastalarda saptanan hassas nokta sayısının 25(OH)D değerleriyle ilişkili olmadığı sonucuna varılmıştır.Abstract: The aim of this study was to evaluate 25(OH)D levels in patients with fibromyalgia syndrome and to investigate the relationship between tender point count and 25(OH)D levels.Sixty one patients with a diagnosis of fibromyalgia were included in this retrospective study between 2016-2017. Demographic data of patients, 25(OH)D levels, number of tender points were evaluated. Patients were classified as vitamin D deficiency (<20 ng/ml), vitamin D insufficient (20-30 ng/ml) and normal vitamin D level (> 30 ng /ml) according to 25(OH)D levels. The mean 25(OH)D levels of 61 patients with firomyalgia was 18.08±11.72. When vitamin D levels were examined, vitamin D deficiency was found in 40 patients with fibromyalgia and vitamin D deficiency in 14 patients with fibromyalgia. Only 7 (11,48%) of the patients with fibromyalgia had normal vitamin D levels. There was no significant correlation between 25(OH)D levels and tender point counts of patients. It was concluded that the vitamin D levels were low in the majority of patients with fibromyalgia, however the number of tender point detected in patients with fibromyalgia was not related to 25(OH)D values.

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Vitamin D Related Musculoskeletal System Findings

Cited by 4 publications

References 24 publications

Fi̇bromi̇yalji̇ Tedavi̇si̇ Alan Hastalarda 25-Hi̇droksi̇ Vi̇tami̇n D Düzeyleri̇ni̇n Değerlendi̇ri̇lmesi̇

Fi̇bromi̇yalji̇ Tedavi̇si̇ Alan Hastalarda 25-Hi̇droksi̇ Vi̇tami̇n D Düzeyleri̇ni̇n Değerlendi̇ri̇lmesi̇

Investigation of neuropathic pain in women with low vitamin D levels

Fibromiyalji Sendromunda D Vitamin Düzeylerinin Değerlendirilmesi

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