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average 25-hydroxyvitamin D (25(OH)D) concentration rises to a peak within 2 weeks, then gradually declines towards the baseline concentration over a period of about 2 months (Armas et al., 2004;Ilahi et al., 2008). The single dose of 60 000 IU D3 administered by Sahu et al. in the 5th month of gestation would not be expected to have a perceptible effect on 25(OH)D concentrations in most women at delivery, which was the only time at which the biochemical response was assessed. Even the larger doses administered later in pregnancy would have been predicted to have minor effects on the 25(OH)D concentration measured at delivery, despite almost certainly having caused important but undetected elevations in 25(OH)D concentration during the third trimester. Therefore, it is incorrect to conclude from Sahu et al.'s report that the reported supplement regimens had little or no effect on vitamin D status during pregnancy.The interpretation of the data is further complicated by the unspecified variation in the precise length of the interval between D3 dosing and 25 ( Conflict of interestThe author declares no conflict of interest. Vitamin D replacement in pregnant women in rural north India: a pilot study. DE Roth
average 25-hydroxyvitamin D (25(OH)D) concentration rises to a peak within 2 weeks, then gradually declines towards the baseline concentration over a period of about 2 months (Armas et al., 2004;Ilahi et al., 2008). The single dose of 60 000 IU D3 administered by Sahu et al. in the 5th month of gestation would not be expected to have a perceptible effect on 25(OH)D concentrations in most women at delivery, which was the only time at which the biochemical response was assessed. Even the larger doses administered later in pregnancy would have been predicted to have minor effects on the 25(OH)D concentration measured at delivery, despite almost certainly having caused important but undetected elevations in 25(OH)D concentration during the third trimester. Therefore, it is incorrect to conclude from Sahu et al.'s report that the reported supplement regimens had little or no effect on vitamin D status during pregnancy.The interpretation of the data is further complicated by the unspecified variation in the precise length of the interval between D3 dosing and 25 ( Conflict of interestThe author declares no conflict of interest. Vitamin D replacement in pregnant women in rural north India: a pilot study. DE Roth
Objectives: Fine particulate matter (PM 2.5) is the principal air pollutant and poses a serious threat to public health. This study explored the effects of PM 2.5 on the action spectrum of ultraviolet radiation for vitamin D production (UV vitD) received by manikin surfaces. Methods: Multi-inclination angle ultraviolet radiation monitoring was conducted with different concentrations of PM 2.5. Combining monitoring data with the PM 2.5 concentration, solar elevation angle (SEA), and inclination angle, a UV vitD exposure model for human body multi-inclined surfaces was constructed through a multiple linear regression analysis. A 3D manikin model was used to examine the PM 2.5 effects on UV vitD received by the manikin surface. Results: When PM 2.5 concentrations ranged from 35 µg/m 3 to 100 µg/m 3 (average concentration of PM 2.5 in this range: 62 µg/m 3), the UV vitD received by the whole body was reduced by approximately 8.45% to 19.82% compared with the UV vitD received when PM 2.5 concentrations ranged from 6 µg/m 3 to 35 µg/m 3 (average concentration of PM 2.5 in this range: 17 µg/m 3) with SEAs between 30 • and 50 •. Moreover, the UV vitD dose was reduced by 11.82% in the above comparisons. When further comparing PM 2.5 concentrations from 100 µg/m 3 to 161 µg/m 3 (average concentration of PM 2.5 in this range: 132 µg/m 3) with those from 6 µg/m 3 to 35 µg/m 3 (average concentration of PM 2.5 in this range: 17 µg/m 3), the UV vitD received by the whole body was reduced by approximately 21.6% to 50.64% at SEAs between 30 • and 50 •. The UV vitD dose was reduced by 30.2%. Conclusions: The occurrence of PM 2.5 obviously reduced the UV vitD received by the manikin surface. INDEX TERMS PM 2.5 , ultraviolet radiation, manikin model, inclination angle, Vitamin D.
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