Vitamin D safety and requirements

Paula, Francisco José Albuquerque de; Rosen, Clifford J.

doi:10.1016/j.abb.2011.12.002

Cited by 51 publications

(38 citation statements)

References 121 publications

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“…The role of vitamin D in nonbone related end points, such as mortality, cardiovascular risk, cancer and autoimmune diseases is still controversial (39,40). There is a consensus that 25(OH)D (calcidiol) is the most abundant metabolite and the best indicator for the evaluation of vitamin D status (A), the indivi duals being classified as: deficient, insufficient of suf ficient in vitamin D (3,6,41,42).…”

Section: What Are the Effects On Bone Metabolism?mentioning

confidence: 99%

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Maeda

Borba

Camargo

et al. 2014

Arq Bras Endocrinol Metab

228

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Objective: The objective is to present an update on the diagnosis and treatment of hypovitaminosis D, based on the most recent scientific evidence. Materials and methods: The Department of Bone and Mineral Metabolism of the Brazilian Society of Endocrinology and Metabology (SBEM) was invited to generate a document following the rules of the Brazilian Medical Association (AMB) Guidelines Program. Data search was performed using PubMed, Lilacs and SciELO and the evidence was classified in recommendation levels, according to the scientific strength and study type. Conclusion: A scientific update regarding hypovitaminosis D was presented to serve as the basis for the diagnosis and treatment of this condition in Brazil.

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Section: What Are the Effects On Bone Metabolism?mentioning

confidence: 99%

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Maeda

Borba

Camargo

et al. 2014

Arq Bras Endocrinol Metab

228

View full text Add to dashboard Cite

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“…Several studies have shown that low serum levels of 25[OH]D are common in MS patients throughout the world, particularly in those with advanced disability [27,64,95,[121][122][123]. The optimal 25[OH]D level for maintenance of bone health is, however, debated [124,125]. Several researchers argue that it should be ≥75 nmol/l [126].…”

Section: Conclusion and Expert Commentarymentioning

confidence: 98%

Vitamin D in multiple sclerosis: implications for assessment and treatment

Holmøy¹,

Kampman²,

Smolders³

2012

Expert Review of Neurotherapeutics

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Epidemiological and experimental evidence suggest that a poor vitamin D status is associated with an increased risk of developing multiple sclerosis (MS), and also an unfavorable disease course. Vitamin D may exert relevant effects both on the immune system and on resident cells within the CNS. The data from clinical trials is, however, restricted, and does not allow any conclusion on the effect of high-dose vitamin D supplementation on disease course. The results from sufficiently powered studies will not be available for at least 2 years. MS patients are, however, prone to develop osteoporosis and have increased risk of fractures. Therefore, the authors advise that the serum concentration of 25-hydroxyvitamin D is monitored in order to prevent bone deficit, and that a serum level of 75-125 nmol/l is targeted. This level is sufficient for maintenance of bone health, is not known to be associated with adverse events, and is in the range that has been associated with low risk of developing MS and low disease activity.

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“…D vitamini düşüklüğünün, osteomalazi ve osteoporoz (OP) gibi metabolik kemik hastalıklarının yanı sıra kanser, diyabet, multipl skleroz ve kardiyovasküler olaylar ile ilişkisi tespit edilmiştir (1)(2)(3)(4). D vitamininin, kalsiyum metabolizması yanında güçlü immün modulatuvar etkileri de vardır (5). Genel olarak <30 mcg/L hipovitaminoz, 50 mcg/L optimal kabul edilmekle birlikte, optimal 25(OH)D serum düzeyleri konusunda farklı ülkelerden farklı görüşler bildirilmektedir.…”

Section: Introductionunclassified

Osteoporozlu Hastalarda D Vitamini Düzeyleri

...

2012

tod

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Amaç: Bu çalışma ile hastanemiz osteoporoz izlem polikliniğine başvuran hastaların D vitamini düzeylerini saptamayı ve ilişkili parametreleri belirlemeyi amaçladık. Gereç ve Yöntem: İbn-i Sina Hastanesi osteoporoz izlem polikliniğinde 2003-2011 yılları arasında takipli 940 hastanın dosyaları üzerinden retrospektif olarak yaş, cinsiyet, meslek, eğitim düzeyi, menapoz durumu ve yaşı ile başvuru anındaki D vitamini düzeyleri kaydedildi. D vitamini düzeyleri 4 gruba ayrıldı: 30-80 mcg/L, yeterli (sufficient); 21-30 mcg/L, yetersiz (insufficient); 11-20 mcg/L, eksik (deficient); 0-10 mcg/L, osteomalazik (osteomalasic) kabul edildi. D vitamini düzeyi, her bir parametreyle istatistiksel olarak karşılaştırıldı. Bulgular: Hastaların yaş ortalaması 61,0±10,8 (23-89) yıl idi. Bu hastalardan 867'si (%92,2) kadın, 73'ü (%7,8) erkekti. Hastaların büyük çoğunluğu ev hanımıydı (%72,6). Hastaların eğitim düzeyi genelde ilkokuldu (%45,6). Hastalardan menopoza girenlerin sayısı 777 (%82,7) ve ortalama menapoz yaşı 45,69±6,16'ydı. Hastaların D vitamini düzeyleri ortalaması 26,13±18,62 mcg/L idi. D vitamini düzeyine göre grupladığımızda yaklaşık %70'inin normalin altında kaldığı görüldü. Osteomalazik düzeyde değerleri olan hasta %16,3'tü. D vitamini düzeyi yeterli olan hasta %31,5'ti. D vitamini düzeyiyle cinsiyet arasında anlamlı fark bulundu ve kadınlarda D vitamini daha düşük saptandı (χ 2 =9,63, p=0,022). D vitamini düzeyinin meslek, eğitim düzeyi, yaş ve menopoz süresi ile bir ilişkisi bulunamadı. Sonuç: Osteoporoz izlem polikliniğimize başvuran hastalarda D vitamini düzeyleri %70'e yakın oranda normalin altında bulundu. Ayrıca kadınlarda D vitamini düzeyi anlamlı biçimde daha düşük saptandı. Bu konuda risk faktörlerine odaklı ileri çalışmalara ihtiyaç vardır. (Türk Os te opo roz Dergisi 2011;17:68-70) Anah tar ke li me ler: D vitamini, osteoporoz, cinsiyet Summary Özet Orijinal Araştırma / Original Investigation 68Aim: In this study, we aimed to determine vitamin D levels and related parameters of patients referring to our osteoporosis follow-up clinic. Material and Methods: Age, gender, occupation, education level, menopausal state, menopause age and vitamin D levels on admission were recorded retrospectively from files of 940 patients, who had been followed between years 2003-2011 at İbn-i Sina osteoporosis follow-up clinic. Vitamin D levels divided into four groups and accepted as 30-80 mcg/L sufficient, 21-30 mcg/L insufficient, 11-20 mcg/L deficient and 0-10 mcg/L osteomalasic. Results: Mean age of the 940 patients was 61.0±10.8 (23-89) years. 867 (92.2%) were female and 73 (7.8%) were male patients. Most of the patients were housewomen (72.6%). Educational level of the patients was usually primary school (45.6%). The number of menopausal patients was 777 (82.7%) and mean menopause age was 45.69±6.16. The mean vitamin D level of the patients was 26.13±18.62 mcg/L. When we grouped patients according to vitamin D levels, approximately 70% were below normal. Patients who had osteomalasic levels were 16.3%. Patients with suffi...

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Vitamin D safety and requirements

Cited by 51 publications

References 121 publications

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Vitamin D in multiple sclerosis: implications for assessment and treatment

Osteoporozlu Hastalarda D Vitamini Düzeyleri

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