Vitamin D Serum Level, Disease Activity and Functional Ability in Different Rheumatic Patients

Grazio, Simeon; Grubišić, Frane; Kavanagh, Hana Skala; Naglić, Đurđica Babić; Anić, Branimir; Bakula, Marija; Bobek, Dubravka; Kuna, Andrea Tešija; Cvijetić, Selma

doi:10.1097/maj.0000000000000340

Cited by 38 publications

(28 citation statements)

References 22 publications

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“…Therefore, low levels of vitamin D are negatively associated with markers of inflammatory activation (C-reactive protein, CRP) and obesity [35]. Moreover, other studies showed that serum vitamin D levels were also reduced in patients with psoriatic arthritis and being inversely linked to disease activity [46, 47] . …”

Section: The Dermatologist’s Point Of Viewmentioning

confidence: 99%

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

Barrea

Savanelli

Somma

et al. 2017

Rev Endocr Metab Disord

205

188

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Psoriasis is a chronic immune-mediated inflammatory skin disease. Psoriasis lesions are characterized by hyper-proliferation of epidermal keratinocytes associated with inflammatory cellular infiltrate in both dermis and epidermis. The epidermis is the natural source of vitamin D synthesis by sunlight action. Recently, a role for vitamin D in the pathogenesis of different skin diseases, including psoriasis, has been reported. Indeed, significant associations between low vitamin D status and psoriasis have been systematically observed. Due to its role in proliferation and maturation of keratinocytes, vitamin D has become an important local therapeutic option in the treatment of psoriasis. To date, the successful treatment based on adequate dietary intake of vitamin D or oral vitamin D supplementation in psoriasis represent an unmet clinical need and the evidence of its beneficial effects remains still controversial. This information is important either for Dermatologists and Nutritionists to increases the knowledge on the possible bi-directional relationships between low vitamin D status and psoriasis and on the potential usefulness of vitamin D in psoriasis with the aim not only to reduce its clinical severity, but also for delineating the risk profile for co-morbidities cardiac risk factors that may result from psoriasis. In the current review, we analyzed the possible bi-directional links between psoriatic disease and vitamin D.

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Section: The Dermatologist’s Point Of Viewmentioning

confidence: 99%

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

Barrea

Savanelli

Somma

et al. 2017

Rev Endocr Metab Disord

205

188

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“…Similar to this study, there was no difference between the patient and the control group. Comparable results have been demonstrated by various studies [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Besides, Cutolo et al reported a negative correlation between vitamin D and RA disease activity showing a circadian rhythm [8].…”

Section: Discussionmentioning

confidence: 65%

“…Furthermore, it has been showed increasing vitamin D had no association to relative risk of developing RA [10]. However, contradictory results have been published in the literature about vitamin D and RA activity [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. It has been reported that vitamin D has a negative correlation between DAS28, CRP and HAQ values [25] Therefore, the aim of the present study was to evaluate the vitamin D level in patients with RA and association with clinic and laboratory parameters and quality of life.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status and association with disease activity and quality of life in patients with rheumatoid arthritis

Şaş¹,

Koçak²,

Kurt³

et al. 2019

Ann Clin Anal Med

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Aim: The aim of this study is to determine the vitamin D level in patients with RA (Rheumatoid Arthritis) and association with clinic and laboratory parameters and quality of life. Material and Method: Out of 111 patients with RA and 107 healthy controls who were admitted to Ahi Evran University Training and Research Hospital were included in this study. Patients underwent clinical, laboratory, functional, and quality of life examination. Laboratory tests used for patient evaluations included complete blood count, erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP). Disease activity was calculated by DAS28 (Disease Activity Score) and functional and quality of life was examined by RAQoL (Rheumatoid Arthritis Quality of Life), HAQ (Health Assessment Questionnaire). Larsen score was calculated to assess the radiographic damage. Results: There was no significant difference between the patient and control groups regarding age, sex and vitamin D level (p > 0.05). There were no correlation between vitamin D and Larsen score, RAQoL, HAQ, ESR, and CRP (p > 0,05). We found negative correlation between DAS28 (Disease Activity Score) and vitamin D (r = -0,416, p = 0,014). We found negative correlation between morning stiffness and vitamin D (r = -0,454, p = 0,007). Patients with RA were divided into two groups with D vitamin deficiency (0-19 ng / mL) and vitamin D ( > 20 ng / mL). There was a negative correlation with morning stiffness in the group with vitamin D deficiency (r = -0,454, p = 0,007). There was a negative correlation between DAS28 score and vitamin D deficiency (r = -0.416, p = 0.014). Discussion: This study presents a negative correlation between serum vitamin D level and DAS28. Since vitamin D has autoimmune roles, deficiency or inadequacy can cause flaring in patients with RA. In the light of these findings, we recommend vitamin D supplementation.

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“…The association between vitamin D deficiency and autoimmune disorders such as RA, SLE, multiple sclerosis and inflammatory bowel disease (IBD) has been widely reported. A recent meta‐analysis and earlier reports have shown lower serum vitamin D in RA patients associated with increased disease activity. Independent follow‐up studies have also shown that vitamin D‐deficient RA patients are susceptible for recurrence of disease with higher disease activity and worse quality of living indices .…”

mentioning

confidence: 82%

Vitamin D: The unexplored immunomodulator

Das

Panda

2016

Int J of Rheum Dis

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Vitamin D Serum Level, Disease Activity and Functional Ability in Different Rheumatic Patients

Cited by 38 publications

References 22 publications

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

Vitamin D status and association with disease activity and quality of life in patients with rheumatoid arthritis

Vitamin D: The unexplored immunomodulator

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