Vitamin D serum level in major depressive disorder and schizophrenia

Okasha, Tarek; Sabry, Walaa; Hashim, Mostafa Ahmad; Abdeen, Mai SeifElDin; Abdelhamid, Abdelhamid M.

doi:10.1186/s43045-020-00043-y

Cited by 10 publications

(11 citation statements)

References 59 publications

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“…Studies have shown multiplex interactions between biological, psychological, and environmental factors giving rise to the association between obesity and depression [4]. Amongst the contributing factors of depression, vitamin D deficiency has increasingly drawn attention in recent years [5].…”

Section: Introductionmentioning

confidence: 99%

“…This hormone binds to receptors in numerous brain regions including the hippocampus and cingulate cortex, which are involved in the pathogenesis of depression and other mental illnesses [6]. Many clinical studies have found depression, anxiety and cognitive impairment to be associated with low serum levels of 25-hydroxyvitamin D [25(OH)D], which is the major circulating form of vitamin D, in average weight people [5][6][7]. Recent research has also provided evidence for antidepressant properties of vitamin D supplementation [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D deficiency and depression in obese adults: a comparative observational study

et al. 2021

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Background Amongst the contributing factors of depression, vitamin D deficiency has increasingly drawn attention in recent years. This paper seeks to examine the association between serum vitamin D level and depression in patients with obesity. Methods In this comparative observational study, serum 25-hydroxyvitamin D [25(OH)D] levels were compared between obese individuals with depression (n = 174) and those without depression considering the effect of potential confounders. Participants were selected from males and females aged 18 to 60 years old visiting the outpatient obesity clinic of Rasoul-e Akram hospital, Tehran, Iran. The diagnosis of depressive disorder was made based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria. Additional clinical and laboratory data were collected from hospital electronic records. Mann–Whitney U test (nonparametric), Student’s t-test (parametric), and Chi-squared test were used to analyze the differences between the two groups. To examine age and gender differences in the relationship between vitamin D deficiency and depression, stratified analyses were conducted by age and gender groups. Results The mean 25(OH) D levels were significantly different between depressed and non-depressed groups (20 ± 15 vs. 27 ± 13, P < 0.001). Vitamin D insufficiency/deficiency was detected in 78 and 67% of the depressed and non-depressed groups, respectively, which was significantly different (P = 0.03). The associations between depression and the serum 25(OH) D levels were observed regardless of gender and age. The overall average vitamin D levels were not significantly different between total males and females (22 ± 13 vs. 23 ± 14, P = 0.49). The average level of vitamin D was higher in the older age group (40–60 years) compared to younger participants (18–39 years) (26 ± 15 vs. 21 ± 13, P = 0.004). Conclusion The present study provides additional evidence for the hypothesis that low vitamin D serum concentration is associated with depression in obese adults, and highlights the need for further research to determine whether this association is causal.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency and depression in obese adults: a comparative observational study

et al. 2021

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“…Studies have shown multiplex interactions between biologic, psychologic, and environmental factors giving rise to the association between obesity and depression (4). Amongst the contributing factors of depression, vitamin D de ciency has increasingly drawn attention in recent years (5).…”

Section: Introductionmentioning

confidence: 99%

“…This hormone binds to receptors in numerous regions of the brain including the hippocampus and cingulate cortex, which are involved in the pathogenesis of depression and other mental illnesses(6). Many clinical studies have found depression, anxiety and cognitive impairment to be associated with low serum levels of 25-hydroxyvitamin D [25(OH)D], which is the major circulating form of vitamin D, in average weight people (5)(6)(7). Recent research has also provided evidence for antidepressant properties of vitamin D supplementation(8, 9).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency and Depression in Obese Adults: A Case- Control Study

Kamalzadeh¹,

Jolfaei²,

Saghafi³

2021

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Background: Depression is one of the most prevalent psychiatric disorders reported in obese population. Amongst the contributing factors of depression, vitamin D deficiency has increasingly drawn attention in recent years. This paper seeks to examine the association between serum vitamin D level and depression in patients with obesity.Methods: This case-control study included 173 depressed obese patients and 174 non-depressed controls. Structured Clinical Interview for DSM-5 (SCID-5) was used to confirm the diagnosis of depression. 25-Hydroxyvitamin D [25(OH)D], Thyroid stimulating hormone (TSH), fasting blood sugar (FBS), parathyroid hormone (PTH) levels, and BMI were assessed in both groups. The statistical analyses included T-test, Chi-squared test, and multivariable logistic regression.Results: The mean 25(OH)D levels were significantly different between the case and control groups (20.43 ± 15.37 vs. 26.55 ± 13.17, P < .001). Vitamin D insufficiency/deficiency was detected in 77.6% and 67.4% of the case and control groups, respectively, which was significantly different (P = .034). Being female, greater age and lower vitamin D levels were associated with greater odds of developing depression (OR = 3.57, 95% CI = 1.82-7.02; OR = 1.05, 95% CI = 1.02-1.07; OR = 1.51, 95%CI = 1.16-1.96, respectively).Conclusion: The present study provides additional evidence with respect to the hypothesis that low vitamin D serum concentration is associated with depression in obese adults, and highlights the need for further research to determine whether this association is causal.

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“…According to World Health Organization (WHO), MDD is a mood disorder with hormonal, neurochemical, and inflammatory alterations [1][2][3][4][5][6]. It has been reported that MDD is present twice in females than in males [7].…”

Section: Introductionmentioning

confidence: 99%

Environmental Pollution to Blame for Depressive Disorder?

Segovia-Mendoza¹,

Palacios-Arreola²,

Pavón³

et al. 2021

Preprint

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Public concern has emerged about the effects of endocrine disruptor compounds (EDCs) on neuropsychiatric disorders. Preclinical evidence suggests that exposure to EDCs is associated with the development of the major depressive disorder (MDD) and could result in neural degeneration. The interaction of EDCs with hormonal receptors is the best-described mechanism of their biological activity. However, the dysregulation of the hypothalamic-pituitary-gonadal adrenal axis has been reported and linked to neurological disorders. On the other hand, at a worldwide level and in Mexico, the incidence of MDD has recently been increasing. Of note, in Mexico, there are no clinical associations on blood levels of EDCs and the incidence of the MDD. Methodology: Thus, we quantified for the first time the serum levels of parent compounds of two bisphenols and four phthalates in patients with MDD. Results: The levels of di-ethyl-hexyl-phthalate (DEHP), butyl-benzyl-phthalate (BBP), di-n-butyl phthalate (DBP), and di-ethyl-phthalate (DEP), bisphenol A (BPA), and bisphenol S (BPS) were determined with a gas chromatograph-mass spectrometer. Results/ conclusion: We found significant differences between concentrations of BBP between controls and patients with MDD.

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Vitamin D serum level in major depressive disorder and schizophrenia

Cited by 10 publications

References 59 publications

Vitamin D deficiency and depression in obese adults: a comparative observational study

Vitamin D deficiency and depression in obese adults: a comparative observational study

Vitamin D Deficiency and Depression in Obese Adults: A Case- Control Study

Environmental Pollution to Blame for Depressive Disorder?

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