Vitamin D status and determinants of deficiency among Palestinian females of childbearing age: A case control study

Mwafy, Saleh; Afana, Wesam Mohammad; Tabash, Ahmad M.

doi:10.1016/j.nutos.2020.12.001

Cited by 2 publications

(4 citation statements)

References 33 publications

(32 reference statements)

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“…In pregnancy, the calcium demand of the fetus results in profound changes in maternal calcium homeostasis, whereas parathyroid plays a major role in calcium and bone metabolism in the non-pregnant state, vitamin D appears to be a prominent regulator during pregnancy [ 8 ]. Several studies have shown that vitamin D deficiency and thyroid function can lead to a series of adverse health disorders during pregnancy, including gestational hypertension, cardiovascular disease, metabolic health, diabetes, multiple sclerosis, bone strength and cancers [ 9 , 10 ]. This study was designed to explore the relationship between vitamin D and thyroid and parathyroid hormone levels in Palestinian pregnant females during the first trimester of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

The impact of vitamin D deficiency on some biochemical parameters and clinical outcome in Palestinian pregnant women during the first trimester

Mwafy

El-Nabi²,

Laqqan³

et al. 2023

PLoS ONE

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Background and aim Vitamin D deficiency is widespread worldwide and associated with negative effects on maternal and neonatal health. This study aimed to evaluate the relationship between vitamin D and thyroid and parathyroid hormone levels in the first trimester of pregnancy. Material and methods This case control study included 200 participants aged (18–40) years divided into two groups; 100 pregnant females at the first trimester as case group, attending the main general clinical centers in Gaza strip, Palestine and 100 apparently healthy non-pregnant females as control group. Vitamin D, free thyroxine, free triiodothyronine, thyroid stimulating hormone, parathyroid, and the autoantibodies specific for thyroglobulin and thyroid peroxidase in serum were measured in all mothers and statistically analyzed using SPSS version 21 software. Results Serum vitamin D, TSH, anti-TPO, and anti-TG levels were significantly decrease while, parathyroid levels were non-significantly decreased in the first trimester of pregnancy compered to control group. The levels of fT4 were significantly increased and level of fT3 were non significantly increased among pregnant mothers compered to control group. Analyses using Pearson correlation coefficients showed positive correlations between vitamin D with fT4, fT3, Anti-TPO with P -value < 0.05 and negative correlations with mother age, TSH, PTH with P-value < 0.05 in early pregnancy. Conclusions Vitamin D deficiency among pregnant women in the first-trimester can be associated with thyroid, parathyroid parameters and thyroid autoantibodies with potential adverse consequences for overall health, emphasizing a routine monitoring and vitamin D supplementation prevention strategies to optimize maternal and fetal outcomes.

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Section: Introductionmentioning

confidence: 99%

The impact of vitamin D deficiency on some biochemical parameters and clinical outcome in Palestinian pregnant women during the first trimester

Mwafy

El-Nabi²,

Laqqan³

et al. 2023

PLoS ONE

Self Cite

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“…In addition, vitamin D deficiency is associated with adverse clinical outcomes like gingival inflammation and impaired bone growth. 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

“…6 Recently, vitamin D deficiency has been considered a global health problem affecting approximately 50% of the worldwide population. 7 It exacerbates many illnesses, such as diabetes mellitus, cardiovascular diseases, autoimmune diseases, osteoporosis, and cancer. In addition, vitamin D deficiency is associated with adverse clinical outcomes like gingival inflammation and impaired bone growth.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, vitamin D deficiency is associated with adverse clinical outcomes like gingival inflammation and impaired bone growth. 7,8 An observational study of 83,779 women aged > 20 years from the Nurses' Health Study demonstrated a strong relationship between vitamin D deficiency and an increased risk of type 2 diabetes. Also, it suggests that a daily intake of vitamin D and calcium can reduce the risk by 33%.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Deficiency Association with Comorbid Diseases in Palestine: “A Cross-Sectional Observation Study”

Abukhalil¹,

Falana²,

Yasser³

et al. 2022

IJGM

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Background Vitamin D deficiency (VDD) is a global health concern. This study aimed to determine the prevalence of vitamin D deficiency and its associated comorbidities in Palestine, such as diabetes mellitus, hypertension, hyperlipidemia, and cardiovascular and autoimmune diseases. Methods A retrospective, descriptive study retrieved medical data from the Nat Health insurance processor database from 2014 to 2020. Patient information included age, sex, vitamin D laboratory order, symptoms, and comorbidities. This study included patients prescribed vitamin D at a dose of 50000IU for vitamin D deficiency confirmed by a serum vitamin D laboratory test. The collected data were analyzed using IBM SPSS. In addition, a chi-square test was conducted to assess the association between vitamin D deficiency, symptoms, and comorbidities. Results Data of 3011 patients were collected; 639 patients were diagnosed with osteoporosis, and 39 patients prescribed vitamin D without a laboratory test were excluded. Approximately, 1837 (78%) participants had vitamin D deficiency. A total of 1330 women (81.3%) were significantly more likely to have vitamin D deficiency than males, 507 (72.7%; P < 0.001). Joint pain, back pain, and cervicalgia were significantly associated with vitamin D deficiency (P < 0.001). Asymptomatic participants (2.1%) were significantly less likely to have vitamin D deficiency than symptomatic participants (9.5%, p < 0.001). Hypothyroidism is significantly associated with vitamin D deficiency (p = 0.048). Conclusion In this retrospective study, the prevalence of vitamin D was high and alarming. There was a significant association between VDD, patients who presented with back pain, arthritis, and cervicalgia symptoms, and patients diagnosed with hypothyroidism. Therefore, health initiative programs are warranted to increase awareness regarding screening, prevention, and treatment. Further studies are needed to confirm the relationship between vitamin D supplementation and the reduced risk of comorbid diseases.

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Vitamin D status and determinants of deficiency among Palestinian females of childbearing age: A case control study

Cited by 2 publications

References 33 publications

The impact of vitamin D deficiency on some biochemical parameters and clinical outcome in Palestinian pregnant women during the first trimester

The impact of vitamin D deficiency on some biochemical parameters and clinical outcome in Palestinian pregnant women during the first trimester

Vitamin D Deficiency Association with Comorbid Diseases in Palestine: “A Cross-Sectional Observation Study”

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