Vitamin D Status and Its Relation to Muscle Mass and Muscle Fat in Young Women

Gilsanz, Vicente; Kremer, Arye; Mo, Ashley O.; Wren, Tishya A. L.; Kremer, Ran

doi:10.1210/jc.2009-2309

Cited by 146 publications

(89 citation statements)

References 57 publications

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“…One of these lines found that low serum levels of vitamin D are associated with higher levels of infiltration of fat in muscle in young women (Gilsanz et al, 2010). The other line of research found that low levels of serum vitamin D were associated with low levels of grip strength in adolescent and young adult females (Foo et al, 2009;von Hurst et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Age as a moderator of the secular trend for grip strength in Canada and the United States

Silverman

2014

Annals of Human Biology

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The results are contrary to what might be expected given that body weight has increased in both countries in recent decades and given that grip strength has been found to be positively correlated with body weight. It is suggested that there was a concurrent change in a factor that operated to counteract the effect of increased body weight on grip strength, a prime candidate being a decrease in levels of serum vitamin D. It is also suggested that the secular decline in adult grip strength can be explained by a factor that affects muscular function but which has a long latency period, a prime candidate here being obesity history.

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Section: Discussionmentioning

confidence: 99%

Age as a moderator of the secular trend for grip strength in Canada and the United States

Silverman

2014

Annals of Human Biology

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“…They involve the rapid regulation of membrane calcium channels, suggesting a role for vitamin D in the calcium‐mediated muscle functions, such as muscle contraction and mitochondrial function, which leads to an adequate insulin signalling and muscle substrate metabolism 42. All these findings may clarify the relationship between low vitamin D status and muscle weakness,37, 43 intramuscular fat deposition,44 and resistance to insulin,45 which is related to cardiovascular risk and increased skeletal muscle breakdown 46. Of note, skeletal muscle may also act as a storage site for vitamin D, as recently described 10…”

Section: Vitamin D Physiologymentioning

confidence: 99%

“…Subjects with mutations of the VDR or severe vitamin D deficiency show generalized muscle atrophy, even before biochemical signs of bone disease appear 36, 47. Changes in muscle morphology include derangement of the intermyofibrillar network, increases in intramuscular lipids, and atrophy of the fast‐twitch white (type 2) fibres,11, 44, 48, 49 which are the first to be recruited when preventing a fall. All these changes seem to be reversible,50 supporting co‐ordinated effects of vitamin D in musculoskeletal physiology 51, 52, 53, 54…”

Section: Vitamin D Physiologymentioning

confidence: 99%

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

Molina

Carrero

Bover

et al. 2017

J cachexia sarcopenia muscle

102

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The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. Here, we review how vitamin D represents a pathway in which bone and muscle may interact. In vitro studies have confirmed that the vitamin D receptor is present on muscle, describing the mechanisms whereby vitamin D directly affects skeletal muscle. These include genomic and non‐genomic (rapid) effects, regulating cellular differentiation and proliferation. Observational studies have shown that circulating 25‐hydroxyvitamin D levels correlate with the clinical symptoms and muscle morphological changes observed in CKD patients. Vitamin D deficiency has been linked to low bone formation rate and bone mineral density, with an increased risk of skeletal fractures. The impact of low vitamin D status on skeletal muscle may also affect muscle metabolic pathways, including its sensitivity to insulin. Although some interventional studies have shown that vitamin D may improve physical performance and protect against the development of histological and radiological signs of hyperparathyroidism, evidence is still insufficient to draw definitive conclusions.

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“…The latter is related with vitamin D since in the deficient state, it has been reported that there is increased fat infiltration in the muscle. This physiological mechanism is associated with lower levels of muscle strength and physical performance, independent of muscle mass [172]. To date, a number of organizations recognize that vitamin D is directly related with the falls in the elderly, including the International Osteoporosis Foundation, the Endocrine Society, and the US Preventive Services Task Force [173].…”

Section: Vitamin D In Non-athletesmentioning

confidence: 99%

Vitamin D and Physical Activity

Koundourakis¹,

Margioris²

2017

A Critical Evaluation of Vitamin D - Basic Overview

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Vitamin D is synthesized in the skin following exposure to ultraviolet radiation, producing cholecalciferol, while only a small percentage of the circulating vitamin D is of exogenous origin deriving from food. Following two sequential hydroxylations, in the liver and in the kidneys, vitamin D is fully activated. Although its role in bone physiology and calcium homeostasis is well documented, there is emerging evidence that vitamin D exerts a plethora of additional effects on most tissues regulating the musculoskeletal, cardiovascular, and immune systems as well as energy homeostasis. Its deficiency/insufficiency poses a major public health problem observed in all age groups and regardless of latitude and insolation. In muscles, vitamin D deficiency is associated with a decline in neuromuscular function including muscular strength, walking speed, balance, jumping and sprinting performance, and aerobic capacity, although the evidence is still weak regarding its effects in the young and the athletes. Supplementation counteracts the negative effects of vitamin D deficiency on performance although in individuals with adequate levels of vitamin D, additional supplementation does not appear to enhance further physical capabilities. The aim of this chapter is to review our current understanding of diverse effects of vitamin D in physical performance in athletic and nonathletic populations.

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Vitamin D Status and Its Relation to Muscle Mass and Muscle Fat in Young Women

Abstract: We found that vitamin D insufficiency is associated with increased fat infiltration in muscle in healthy young women.

Cited by 146 publications

References 57 publications

Age as a moderator of the secular trend for grip strength in Canada and the United States

Age as a moderator of the secular trend for grip strength in Canada and the United States

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

Vitamin D and Physical Activity

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