Vitamin D status and its associations with components of metabolic syndrome in healthy children

Mellati, Ali Awsat; Sharifi, Faranak; Faghihzade, Soghrat; Mousaviviri, Seyed Akbar; Chiti, Hossein; Kazemi, Seyed Ali Naghi

doi:10.1515/jpem-2013-0495

Cited by 23 publications

(20 citation statements)

References 18 publications

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“…A study in healthy Iranian children reported a significantly higher prevalence of vitamin D deficiency in girls than boys (42.9% vs. 16.4%, respectively) (21). In this study we did not observe any demographic or clinical risk characteristics for low vitamin D level except for the difference between sites which might be explained by geographic, cultural, and nutritional factors.…”

Section: Discussioncontrasting

confidence: 70%

Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy

Aurpibul

Sricharoenchai

Wittawatmongkol

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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Section: Discussioncontrasting

confidence: 70%

Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy

Aurpibul

Sricharoenchai

Wittawatmongkol

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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“…In fact, particularly obesity has been independently associated with low 25(OH)D levels and dyslipidemia [2,8]. Nevertheless, different authors have described-as it occurred in this study-the existence of an association between Vitamin D status and lipid profile in children and adolescents [15,[25][26][27].…”

Section: Discussionmentioning

confidence: 49%

Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity

et al. 2020

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Background/Objectives. Obesity is associated with cardiometabolic risk factors and with Vitamin D deficiency. The aim of this study was to examine the relationship between 25(OH)D concentrations and cardiometabolic risk factors in adolescents with severe obesity. Subjects/Methods. A cross-sectional clinical assessment (body mass index, fat mass index, fat-free mass index, waist-to-height ratio, and blood pressure) and metabolic study (triglycerides, total cholesterol, HDL-C, LDL-C, glucose, insulin, HOMA-IR, leptin, calcium, phosphorous, calcidiol, and PTH) were carried out in 236 adolescents diagnosed with severe obesity (BMI z-score > 3.0, 99th percentile), aged 10.2-15.8 years. The criteria of the US Endocrine Society were used for the definition of Vitamin D status. Results. Subjects with Vitamin D deficiency had significantly elevated values (p < 0.05) for BMI z-score, waist circumference, waist z-score, body fat percentage, fat mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, LDL-C, insulin, HOMA-IR, leptin, and PTH than subjects with normal Vitamin D status. There was a significant negative correlation (p < 0.05) of serum 25(OH)D levels with body fat percentage, FMI, systolic BP, total cholesterol, triglyceride, LDL-C, glucose, insulin, HOMA-IR, leptin, and PTH. Conclusions. Low Vitamin D levels in adolescents with severe obesity were significantly associated with some cardiometabolic risk factors, including body mass index, waist circumference, fat mass index, high blood pressure, impaired lipid profile, and insulin resistance.

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“…It is estimated that more than 1 billion people have suffered from VDD [7]. VDD causes a variety of disorders that include but are not limited to calcium and phosphorus metabolism disorder, infection, autoimmune disease, tumours and allergic disease [8-10]. A potential link between VD and the development of allergic disease (the so-called “vitamin D hypothesis”) first emerged when higher rates of allergic disease were observed in people residing at higher latitudes, where VDD is common [11].…”

Section: Introductionmentioning

confidence: 99%

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Xiang

Wang

2019

Dermatology

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Background: Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. Objective: We detected serum levels of VA and VD in children with AD to explore how VA deficiency (VAD) and VDD affect AD severity. Methods: We assessed the SCORing Atopic Dermatitis (SCORAD) index, total immunoglobin E levels and peripheral blood eosinophil counts. VA and VD levels were determined with high-performance liquid chromatography. Correlations among variables were investigated with Pearson’s correlation analysis. Results: The VD and VA levels were significantly lower in children with AD than in normal children (p < 0.001, p = 0.0423). Both VD and VA levels were negatively correlated with SCORAD scores. The SCORAD scores were significantly higher in AD patients with both VDD and VAD (co-deficiency) than in other AD patients. Significant inverse correlations were observed between peripheral blood eosinophil counts and serum VA and VD levels. Conclusions: VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.

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Vitamin D status and its associations with components of metabolic syndrome in healthy children

Cited by 23 publications

References 18 publications

Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy

Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy

Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

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