Vitamin D Status and Muscle Function in Post-Menarchal Adolescent Girls

Ward, Kate A; Das, Gautam; Berry, Jacqueline; Roberts, Stephen A.; Rawer, Rainer; Adams, Judith E.; Mughal, Zulf

doi:10.1210/jc.2008-1284

Cited by 246 publications

(197 citation statements)

References 29 publications

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“…Fitness may also be associated with vitamin D concentrations because greater fitness is likely linked to increased outdoor activities (38) and thus exposure to sunlight (6) , as predicted in the present study. It should however also be mentioned that girls (12-14 years) with low s-25(OH)D have been shown to generate less power, jump less height and have lower velocity than girls with higher s-25(OH)D concentrations, measured as the 'Esslinger Fitness Index' which represents efficiency and asymmetry of movement and maximum voluntary force of each leg (39) , suggesting that a lower CRF as a consequence of lower 25(OH)D could be one potential explanation for the positive association between CRF and 25(OH)D. Several studies worldwide have reported higher vitamin D status in boys compared with girls, although the reason is unclear (6)(7)(8) , but these studies were only examining vitamin D status, irrespective of intake. In the present study boys had higher fitness and higher intakes of vitamin D than girls, but there was no gender difference in serum vitamin D status.…”

Section: Discussionmentioning

confidence: 99%

Insufficient autumn vitamin D intake and low vitamin D status in 7-year-old Icelandic children

Bjarnadottir

Kristjansdottir

Hrafnkelsson

et al. 2014

Public Health Nutr.

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Objective: The aim was to investigate autumn vitamin D intake and status in 7-year-old Icelanders, fitting BMI and cardiorespiratory fitness as predictors. Design: Three-day food records and fasting blood samples were collected evenly from September to November, and cardiorespiratory fitness was measured with an ergometer bike. Conclusions: A minority of children followed the vitamin D recommendations and 65 % had suboptimal vitamin D status during the autumn. Week of autumn was more strongly associated with vitamin D status than diet or cardiorespiratory fitness, which associated with vitamin D status to a similar extent. These results demonstrate the importance of sunlight exposure during summer to prevent suboptimal vitamin D status in young schoolchildren during autumn in northern countries. An increased effort is needed for enabling adherence to the vitamin D recommendations and increasing outdoor activities for sunlight exposure.

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Section: Discussionmentioning

confidence: 99%

Insufficient autumn vitamin D intake and low vitamin D status in 7-year-old Icelandic children

Bjarnadottir

Kristjansdottir

Hrafnkelsson

et al. 2014

Public Health Nutr.

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“…Consequently, jumping mechanography provides sound clinical evaluation of vitamin D's impact on muscles required for locomotion [35]. Jumping mechanography has also been found to evaluate a broader range of individuals with lesser physical capabilities [140].…”

Section: Assessment Of Muscle Power In Children With Oimentioning

confidence: 99%

“…This relationship has been shown in pre and post menarcheal healthy girls however it has yet to be studied in the OI population [34,35]. Through its effect on muscle size and function, vitamin D plays an important role in acquisition of muscle strength [33].…”

Section: Introductionmentioning

confidence: 98%

Effect of high-dose vitamin D supplementation on bone density in youth with osteogenesis imperfecta: A randomized controlled trial

Plante

Veilleux

Glorieux

et al. 2016

Bone

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Background Osteogenesis imperfecta (OI) is a genetic disease characterized by fragile bones and short stature. Recently, a positive association was found between serum 25‐hydroxyvitamin D (25OHD) concentrations and lumbar spine areal bone mineral density (LS‐aBMD) z‐scores in this population. Objectives: To assess whether high‐dose vitamin D supplementation (2000 IU) will result in significantly higher LS‐aBMD z‐scores after one‐year; and to evaluate the effect of vitamin D supplementation on lower limb muscle power. Results: At baseline, average serum 25OHD concentration was 65.6 nmol/L (SD 20.4) with no difference seen between treatment groups (p=0.77). Deficient serum 25OHD concentrations (<50 nmol/L) were measured in only 21% of patients at baseline. Supplementation resulted in higher serum 25OHD concentrations in almost all participants (90%) with significantly higher increases seen with 2000 IU (mean [95% C.I.] = 30.5 nmol/L [21.3; 39.6] vs 15.2 nmol/L [6.4; 24.1], p= 0.02). No significant changes were detected in BMD measurements or in lower limb muscle power between treatment groups from baseline to final visit. Conclusions Supplementation with either 400 or 2000 IU of vitamin D translates into significant increases in serum 25OHD concentrations in children with OI. However, increases in baseline serum 25OHD concentrations already within a healthy range (蠅50 nmol/L) do not translate into increases in BMD z‐scores in children with OI. This research was supported by the Shriners Hospital for Children as well as by The Network for Oral and Bone Health Research.

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“…Also, in young people, a positive relationship between vitamin D status and muscle performance has been reported [2,3]. Given these observations, it is no surprise that 8-12 weeks vitamin D plus calcium supplementation in institutionalized vitamin D-deficient elderly people improved musculoskeletal function by 4-11% [4] and body sway by 9% in ambulatory elderly women [5].…”

Section: Introductionmentioning

confidence: 94%

Effects of alfacalcidol on circulating cytokines and growth factors in rat skeletal muscle

et al. 2011

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Supra-physiological levels of vitamin D induce skeletal muscle atrophy, which may be particularly detrimental in already sarcopaenic elderly. Neither the cause nor whether the atrophy is fibre type specific are known. To obtain supraphysiological levels of circulating vitamin D (1,25(OH) 2 D 3 ) 27.5-month-old female Fischer 344 9 Brown Norway F1 rats were orally treated for 6 weeks with vehicle or the vitamin D analogue alfacalcidol. Alfacalcidol treatment induced a 22% decrease in body mass and 17% muscle atrophy. Fibre atrophy was restricted to type IIb fibres in the low-oxidative part of the gastrocnemius medialis only (-22%; P \ 0.05). There was a concomitant 1.6-fold increase in mRNA expression of the ubiquitin ligase MuRF-1 (P \ 0.001), whereas those of insulin-like growth factor 1 and myostatin were not affected. Circulating IL-6 was unaltered, but leptin and adiponectin were decreased (-39%) and increased (64%), respectively. The treated rats also exhibited a reduced food intake. In conclusion, supraphysiological levels of circulating 1,25(OH) 2 D 3 cause preferential atrophy of type IIb fibres, which is associated with an increased expression of MuRF-1 without evidence of systemic inflammation. The atrophy and loss of body mass in the presence of supra-physiological levels of vitamin D are primarily due to a reduced food intake.

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Vitamin D Status and Muscle Function in Post-Menarchal Adolescent Girls

Abstract: From these data we conclude that vitamin D was significantly associated with muscle power and force in adolescent girls.

Cited by 246 publications

References 29 publications

Insufficient autumn vitamin D intake and low vitamin D status in 7-year-old Icelandic children

Insufficient autumn vitamin D intake and low vitamin D status in 7-year-old Icelandic children

Effect of high-dose vitamin D supplementation on bone density in youth with osteogenesis imperfecta: A randomized controlled trial

Effects of alfacalcidol on circulating cytokines and growth factors in rat skeletal muscle

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