Vitamin D status and premature adrenarche

Akın, Onur; Bideci, Aysun; Döğer, Esra; Akbaş, Emine Demet; Uğurlu, Aylin Kılınç; Yavuz, Süleyman Tolga; Elbeğ, Şehri; Çamurdan, Orhun; Cinaz, Peyami

doi:10.1111/ped.13682

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…Precocious puberty has been associated with increased adiposity, and studies have pointed that this condition could also be related to vitamin D deficiency (Zhao et al 2018;Akın et al 2018). Literature aiming to assess the association between precocious puberty and deficiency of vitamin D is often explained by obesity and/or adiposity (Zhao et al 2018;Akın et al 2018). In addition, the sedentary lifestyle associated with obesity is linked to less activity outside which can favor a reduced Vitamin D endogenous synthesis in the skin from sun exposure (Valtueña et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D levels and its relationship with sex hormones, puberty and obesity degree in children and adolescents

Pires

González-Gil

Anguita‐Ruiz

et al. 2020

Child and Adolescent Obesity

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Background/objectives: Puberty and obesity have been associated with vitamin D deficiency but there is a lack of studies assessing this triple relationship at once. Thus, the aim of this study was to evaluate, under a cross-sectional design, the relationship between sex hormone levels and serum 25-hydroxyvitamin D (25(OH)D), taking into account pubertal status and obesity degree. Subjects/methods: A total of 460 participants from the GENOBOX study (241 females), aged 6-18 years were included in the analysis. Children were divided in groups according to their pubertal stage (prepubertal (n = 225) and pubertal (n = 235)) and obesity degree (normal weight children (n = 100) and children with overweight/obesity (n = 360)). Serum 25(OH)D, Follicle-Stimulating Hormone (FSH) and Luteinizing hormone (LH), estradiol and testosterone were measured. 25(OH)D levels were categorized and the hormones concentration wasadjusted by sex and converted into tertiles. Mann Whitney and Kruskal-Wallis tests, and quantile regression were performed. Results: Pubertal children showed lower serum concentrations of 25(OH)D than prepubertal children (median: 20 ng/mL vs. 24 ng/mL, respectively; p = 0.006). Moreover, within normal weight children, differences were found for 25(OH)D levels according to tertiles of testosterone (I: 27 ng/mL; II: 30 ng/mL; III: 19 ng/ mL, p = 0.008). Among overweight/obese, differences were found according to

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Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D levels and its relationship with sex hormones, puberty and obesity degree in children and adolescents

Pires

González-Gil

Anguita‐Ruiz

et al. 2020

Child and Adolescent Obesity

View full text Add to dashboard Cite

show abstract

“…A total of 43 studies met the criteria for inclusion, which included 10 755 subjects and most of them were girls 9,10, (Tables 1 and 2). Among them, the differences in serum vitamin D concentrations and the risk of precocious puberty were analyzed in 35 9,10,18,[20][21][22][23][24][25][26][28][29][30][31][32][33][36][37][38]40,43,44,[46][47][48][49][50][51][52][53][54][55][56][57][58] and 14 9,10,[18][19][20]25,31,40,48,52,53,[56][57]…”

Section: Resultsmentioning

confidence: 99%

“…Previous findings have established that vitamin D affects the secretion of sex hormones in children and alters the development of reproductive organs of children, and low vitamin D abundance is associated with earlier menarche in girls. 25,53,59 The meta-analysis showed that the average serum vitamin D concentration of subjects with precocious puberty was lower than that of the control group, and the lower level of vitamin D was connected with the risk of precocious puberty. Preliminary observations suggest that vitamin D deficiency can disrupt the transition to puberty through adverse effects on the hypothalamic function.…”

Section: Discussionmentioning

confidence: 99%

Does vitamin D have a potential role in precocious puberty? A meta-analysis

Zhang

Yan

et al. 2023

Food Funct.

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Confirming the association between low serum 25OHD levels in girls with central precocious puberty and its severity

Xu,

Li,

Yuan

2023

BMC Pediatr

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Background To assess the differences in vitamin D levels in girls with rapidly progressive (RP) or slowly progressive (SP) central precocious puberty (CPP) and to compare whether the factors related to RP-CPP influenced the vitamin D status. A cross-sectional study was performed among girls with CPP classified as RP-CPP or SP-CPP. Methods The baseline data, gonadotropin-releasing hormone (GnRH) stimulation test results, serum 25-hydroxyvitamin D (25OHD) levels, and season of sample collection were analyzed. Results The mean 25OHD level in 340 girls was 15.89 ± 6.87 ng/mL, of whom only 10 (2.9%) had normal levels (≥ 30 ng/mL). A total of 114 girls in the SP-CPP group and 226 in the RP-CPP group had similar chronological age, disease course, height SDS, bone mineral density, baseline follicle-stimulating hormone (FSH), peak FSH, and 25OHD levels. Developmental age, body mass index (BMI), BMI SDS, peak luteinizing hormone (LH)/FSH, insulin-like growth factor 1 (IGF-1), and IGF-1 SDS were independent risk factors for RP-CPP. Significant differences were observed among the different serum 25OHD levels in terms of season, disease course, IGF1 level, and BMI SDS (P < 0.05). Moreover, the sampling season was strongly correlated with serum 25OHD levels (r = 0.402, P < 0.001). Conclusion The vitamin D levels were generally deficient or insufficient in girls with CPP, but were not related to the different types of CPP. High BMI levels, IGF1 levels, or peak LH/FSH ratio, but not vitamin D levels, could promote the progression of RP-CPP. Seasonal factors mainly influenced the vitamin D levels.

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Vitamin D status and premature adrenarche

Abstract: Low vitamin D is associated with PA; and insulin resistance may be a factor in this association.

Cited by 5 publications

References 41 publications

Serum 25-hydroxyvitamin D levels and its relationship with sex hormones, puberty and obesity degree in children and adolescents

Serum 25-hydroxyvitamin D levels and its relationship with sex hormones, puberty and obesity degree in children and adolescents

Does vitamin D have a potential role in precocious puberty? A meta-analysis

Confirming the association between low serum 25OHD levels in girls with central precocious puberty and its severity

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