Vitamin D status and prevalence of hypovitaminosis D in different genders throughout life stages: A Brazilian cross-sectional study

Leao, Lenora; Rodrigues, Bernardo; Dias, Paulo Telles Pires; Gehrke, Bárbara; Souza, Thiago da Silva Pereira de; Hirose, Caio Kenji; Freire, Monica Di Calafiori

doi:10.6061/clinics/2021/e2571

Cited by 14 publications

(9 citation statements)

References 53 publications

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“…The median vitamin D baseline values were high, but within the range of a previous study in Rio de Janeiro (n = 24,074) in which samples were analysed between February and April 2018 [38]. The vitamin D synthesis response to UVR is inversely proportional to baseline status [39], thus the high baseline will have decreased the sensitivity of the behavioural responses to the app.…”

Section: Discussionsupporting

confidence: 48%

Innovative digital solution supporting sun protection and vitamin D synthesis by using satellite-based monitoring of solar radiation

Young

Schalka

Temple

et al. 2022

Photochem Photobiol Sci

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Public health campaigns advise minimising UV radiation (UVR) exposure to prevent skin cancer and precancer, e.g. actinic keratosis (AK). A 3-day clinical field study, in Brazil, was performed to evaluate the mobile app Sun4Health® by siHealth Ltd. The app performs real-time monitoring of both erythemal and vitamin D-effective solar radiation doses using satellite data, enabling personalised recommendations on optimal sun exposure time and sunscreen use. When coupled to a wearable device, the app also provides body-site specific recommendations ("3D" version). 59 healthy volunteers were randomised into 3 groups, each given a different app providing: (1) ultraviolet index only (control app), (2) personalised recommendations and sun overexposure alerts (Sun4Health® app), (3) as ( 2) but connected via Bluetooth to a wearable device to monitor sun exposure in 3D (Sun4Health®-3D app). Participants were offered sunscreens (SPF 30 and 50) to use at their discretion. Erythema, quantified by reflectance spectroscopy, was assessed daily in the mornings and evenings on six body sites. Serum vitamin D (25(OH)D 3 ) was measured before and after the study. Mean increase of erythema (Mexameter® units ± SD) of all exposed body sites combined over 3 days showed 55.76 ± 47.47 for group 1, 40.27 ± 37.91 for group 2 and 37.12 ± 30.69 for group 3 (p < 0.05 for all groups). Mean increase of serum 25(OH)D 3 (nmol/l ± SD) showed 1.32 ± 36.49 for group 1, 6.38 ± 21.19 for group 2 and 18.68 ± 35.45 for group 3 (p > 0.05 for all groups). The results show that the Sun4Health® app is safe to use and can modify behaviour to reduce skin erythema (sunburn) yet not decreasing vitamin D status.

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Section: Discussionsupporting

confidence: 48%

Innovative digital solution supporting sun protection and vitamin D synthesis by using satellite-based monitoring of solar radiation

Young

Schalka

Temple

et al. 2022

Photochem Photobiol Sci

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“…It is postulated that vitamin D deficiency represents a global health problem (10) . In Brazil, despite high ultraviolet radiation availability to produce vitamin D in the skin throughout the year, studies have indicated a high prevalence of insufficiency and deficiency (11)(12)(13)(14) , not supporting the common assumption that the level of radiation solar energy in the country guarantees adequate levels of vitamin D (15) . As people age, the risk of vitamin D deficiency increases significantly, mainly due to the decreased capacity for synthesis in the skin (16,17) .…”

mentioning

confidence: 97%

Association between lower serum vitamin D (25-hydroxy-cholecalciferol) concentrations and cognitive impairment in older adults: data from a populational-based cohort study in a middle-income country

Matsuo

Confortin

Ceolin

et al. 2021

Public Health Nutr.

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Objective: To investigate the association between serum vitamin D (25-hydroxy-cholecalciferol) [25(OH)D] concentrations and cognitive impairment in older adults living in Southern Brazil. Design: Cross-sectional analysis using data from the second follow-up wave of the populational-based EpiFloripa Aging Cohort Study collected in 2013-2014. Setting: Cognitive impairment was evaluated using the Mini-Mental State Examination (MMSE). Blood samples were collected to measure serum vitamin D concentrations using a chemiluminescent microparticle immunoassay. Vitamin D concentrations were distributed in quartiles (Q1: 4.0 to 20.7 ng/ml; Q2: 20.8 to 26.6 ng/ml; Q3: 26.7 to 32.0 ng/ml and Q4: 32.1 to 60.1 ng/ml), and its association with cognitive impairment was tested by crude and adjusted logistic regression (sociodemographic, behavioral, and health aspects) using Q4 as a reference group. Participants: 200 men and 371 women aged 60 years or older. Results: The prevalence of probable cognitive impairment was 21.7%. Those without cognitive impairment had higher mean of vitamin D serum concentrations (26.8 vs 24.6, p = 0.014). In the crude analysis, only individuals in Q2 of vitamin D presented an increased risk for probable cognitive impairment compared with Q4 (highest quartile) (OR 2.65, 95% CI 1.46; 4.81), remaining significant in the adjusted analysis (OR 6.04, 95% CI 2.78; 13.13). While Q1 (lowest quartile) was not associated in the crude analysis, but when adjusted, an increased risk of cognitive impairment was observed. Conclusion: The lowest quartile of vitamin D was directly associated with probable cognitive impairment in older adults in Southern Brazil. More studies are needed to investigate whether maintaining adequate serum levels may represent a significant factor in preventing age-related neurological disorders as well as to verify the need for new cutoff points for this age group.

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“…Tem se observado que mesmo em regiões tropicais, a prevalência da hipovitaminose D vem aumentando gradativamente nos últimos anos (Landa et al, 2020;Leão et al, 2021). O Brasil está localizado em uma região geográfica com boa incidência de raios ultravioletas (UVB), durante todo o ano.…”

Section: Resultsunclassified

Deficiência e insuficiência da vitamina D em uma coorte da população de Pernambuco, Brasil

Maia

Correia²,

Silva³

et al. 2022

RSD

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A vitamina D tem um importante papel na imunidade e sua deficiência ou insuficiência (hipovitaminose D) pode estar relacionada com o aumento da prevalência das doenças autoimunes. Em um estudo de coorte retrospectivo com amostras simples, advindas de um banco de dados hospitalar público, foi verificado o perfil de vitamina D de uma população. Participaram da pesquisa 2.977 pacientes de 127 municípios de Pernambuco, Brasil. Em 12,6% dos municípios foram encontradas médias normais de vitamina D (D≥30ng/ml) e em 87,4% hipovitaminose D (concentração sérica de D <30ng/mL). Recife expôs o maior número de habitantes com deficiência de vitamina D (321) e apresentou 100% da amostra feminina (n=650) com hipovitaminose D (D<30ng/ml). A deficiência de vitamina D (D≤20ng/mL) neste município foi identificada em 20,3% da amostra e a insuficiência (D≥20ng/mL<30ng/mL) em 79,7%. Nas cidades circunvizinhas a Recife, a média de deficiência de vitamina D foi 13,3% e a de insuficiência 86,7%. Com relação ao envolvimento da hipovitaminose D com doenças autoimunes, os artigos do estudo ressaltaram a associação da hipovitaminose D com o risco de doenças autoimunes. Quanto à prevalência da hipovitaminose D nas doenças autoimunes, 93,0% dos artigos concordaram com esta associação. Sobre a influência da hipovitaminose D na atividade da doença autoimune, 63,6% reconheceram esta associação. A predominância da hipovitaminose D está se agravando, principalmente, na população feminina e sem distinção de

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Vitamin D status and prevalence of hypovitaminosis D in different genders throughout life stages: A Brazilian cross-sectional study

Cited by 14 publications

References 53 publications

Innovative digital solution supporting sun protection and vitamin D synthesis by using satellite-based monitoring of solar radiation

Innovative digital solution supporting sun protection and vitamin D synthesis by using satellite-based monitoring of solar radiation

Association between lower serum vitamin D (25-hydroxy-cholecalciferol) concentrations and cognitive impairment in older adults: data from a populational-based cohort study in a middle-income country

Deficiência e insuficiência da vitamina D em uma coorte da população de Pernambuco, Brasil

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