Vitamin D status and response to growth hormone treatment in prepubertal children with growth hormone deficiency

Durá-Travé, Teodoro; Gallinas-Victoriano, Fidel; Moreno-González, Paula; Urretavizcaya-Martinez, María; Berrade-Zubiri, Sara; Chueca-Guindulain, María Jesús

doi:10.1007/s40618-020-01227-3

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…Vitamin D is an essential nutrient for metabolism and plays an important role in the development of children. The addition of exogenous vitamin D can promote the absorption of calcium and promote bone growth and development [ 17 , 18 ]. rhGH is an exogenous growth hormone preparation, which has the effect of growth hormone and can upregulate the expression of growth hormone.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Combined with Recombinant Human Growth Hormone in Children with Growth Hormone Deficiency

et al. 2022

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Objective. Growth hormone deficiency (GHD) refers to the complete or partial lack of pituitary growth hormone synthesis and secretion. This study is aimed at investigating the efficacy of vitamin D and recombinant human growth hormone (rhGH) in children with GHD. Methods. A total of 100 children with GHD at our hospital were included between 1st January 2018 and 31st October 2020. The patients were divided into a study group ( n = 70 , received vitamin D combined with rhGH) and a control group ( n = 30 , received rhGH). The growth and development (bone age, growth rate, and height), bone metabolism (bone alkaline phosphatase (BAP), β-collagen degradation product (β-CTX), osteocalcin (OC), and amino-terminal propeptide type I procollagen (PINP)), insulin-like growth factor 1 (IGF-1), ghrelin, and adverse reactions in the two groups were measured before and 12 months after treatment. Results. There were no significant differences in the bone age, growth rate, and height between the two groups before treatment. After 12 months of treatment, the bone age, growth rate, and height of the study group were significantly higher than those of the control group. After 12 months of treatment, the levels of serum BAP, PINP, and OC in the study group were significantly higher than those in the control group, while the levels of β-CTX in the study group were significantly lower than those in the control group. The serum IGF-1 level in the study group was significantly higher than that in the control group, while the ghrelin level in the study group was lower. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion. Combined rhGH and vitamin D treatment can promote growth and development, improve bone metabolism, and regulate IGF-1 and ghrelin levels.

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Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Combined with Recombinant Human Growth Hormone in Children with Growth Hormone Deficiency

et al. 2022

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“…The research results obtained in the control group seem to be worrying since blood vitamin D level was considerably lowered in the children compared to the normal range of 14.69-18.80 ng/ml (norm 30-80 ng/ml). Dura-Trave et al [24] noticed that GH treatment, at least during the first 2 years, does not modify the vitamin D levels. Vitamin D deficiency could condition the response to GH therapy so vitamin D monitoring should be considered as part of the routine evaluation of children with GH treatment.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D, calcium and phosphorus status in children with short stature – effect of growth hormone therapy

Klatka¹,

Partyka²,

Polak³

et al. 2021

Ann Agric Environ Med.

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Objective. The aim of the study was to assess the level of calcium, phosphorus and vitamin D in the blood of patients treated for short stature (SS). Materials and method. The study encompassed 110 children treated for somatotropin hypopituitarism (SHP) in the Department of Paediatric Endocrinology and Diabetology at the Medical University of Lublin. The levels of calcium, phosphorus and vitamin D were marked for both groups in the peripheral blood collected on a routine basis for diagnostic examinations. The parameters were compared within the group of children with SHP, both the patients who were about to start the therapy and those in the course of the therapy as well as between the research group (110 children) and the control group. Results. The results obtained were compared with the results in the control group that comprised 41 children with a general good health status, although with nasal septum deviation treated in the Department of Paediatric Otolaryngology at the Medical University of Lublin. Conclusions. On the basis of the research performed, the following conclusions were drawn: 1) children with SHP were characterised with calcium-phosphorus imbalance. The level of calcium, phosphorus and vitamin D was diminished. The values did not change due to a several-year hormone growth treatment (HGT). 2) the level of calcium and phosphorus was appropriate in the control group children, but the vitamin D level was considerably lowered. This shows the necessity for vitamin D control and supplementation, not only in children with SS.

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“…Khadilkar et al [16] .showed that the administration of calcium and vitamin D had a beneficial effect on the augmentation of bone elements for kids with SHP who received GH treatment. Durá-Travé et al [17] .observed that growth hormone (GH) administration does not alter vitamin D levels, particularly during the first 2 years. Vitamin D deficiency may impact the effectiveness of GH therapy.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Vitamin D and Glucose Level in Children with Growth Hormone Treatment

2024

The Egyptian Journal of Hospital Medicine

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Vitamin D status and response to growth hormone treatment in prepubertal children with growth hormone deficiency

Cited by 6 publications

References 28 publications

Effect of Vitamin D Combined with Recombinant Human Growth Hormone in Children with Growth Hormone Deficiency

Effect of Vitamin D Combined with Recombinant Human Growth Hormone in Children with Growth Hormone Deficiency

Vitamin D, calcium and phosphorus status in children with short stature – effect of growth hormone therapy

Correlation between Vitamin D and Glucose Level in Children with Growth Hormone Treatment

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