Vitamin D status and seroconversion for COVID-19 in UK healthcare workers

Faniyi, Aduragbemi A; Lugg, Sebastian T; Faustini, Sian; Webster, Craig; Duffy, Joanne; Hewison, Martin; Shields, Adrian M; Richter, Alex; Thickett, David

doi:10.1183/13993003.04234-2020

Cited by 31 publications

(34 citation statements)

References 14 publications

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“…A cross-sectional study reported vitamin D deficiency (<12 ng/ml; <30 nmol/l) in 15.6% of the samples from individuals with symptoms suggestive of COVID-19, and the presence of antibodies to the SARS-CoV-2 virus was higher in subjects with vitamin D deficiency compared with that in individuals with higher levels of 25(OH)D (P=0.003) ( 91 ). In addition, vitamin D deficiency was identified as an independent factor for seropositivity to SARS-CoV-2 in subjects with COVID-19 symptoms ( 91 ). Therefore, Faniyi et al ( 91 ) conclude that supplementation with vitamin D may be an adequate therapeutic strategy for preventing or alleviating COVID-19.…”

Section: Vitamin D and Covid-19mentioning

confidence: 99%

Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review)

Turrubiates-Hernández¹,

Sánchez-Zuno²,

González-Estévez³

et al. 2021

Int J Mol Med

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Currently, the world is under a pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease 2019 (COVID-19). This disease is characterized by a respiratory syndrome that can progress to an acute respiratory distress syndrome. To date, limited effective therapies are available for the prevention or treatment of COVID-19; therefore, it is necessary to propose novel treatment options with immunomodulatory effects. Vitamin D serves functions in bone health and has been recently reported to exert protective effects against respiratory infections. Observational studies have demonstrated an association between vitamin D deficiency and a poor prognosis of COVID-19; this is alarming as vitamin D deficiency is a global health problem. In Latin America, the prevalence of vitamin D deficiency is unknown, and currently, this region is in the top 10 according to the number of confirmed COVID-19 cases. Supplementation with vitamin D may be a useful adjunctive treatment for the prevention of COVID-19 complications. The present review provides an overview of the current knowledge of the potential immunomodulatory effects of vitamin D in the prevention of COVID-19 and sets out vitamin D recommendations for the Latin American population.

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Section: Vitamin D and Covid-19mentioning

confidence: 99%

Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review)

Turrubiates-Hernández¹,

Sánchez-Zuno²,

González-Estévez³

et al. 2021

Int J Mol Med

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“…Inverse associations between vitamin D levels and COVID-19 infection were furthermore consistently reported from a case-control study of 201 hospitalized patients and 201 matched controls from Iran [ 7 ] and in a cross-sectional study among 392 healthcare workers from the United Kingdom [ 8 ]. Finally, negative correlations between mean levels of vitamin D and COVID-19 infection and mortality rates were also reported from an ecological study including 20 European countries [ 9 ].…”

Section: Potential Role Of Vitamin D Supplementation For Preventinmentioning

confidence: 76%

Vitamin D Supplementation to Prevent COVID-19 Infections and Deaths—Accumulating Evidence from Epidemiological and Intervention Studies Calls for Immediate Action

Brenner

2021

Nutrients

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The COVID-19 pandemic poses an unprecedented threat to human health, health care systems, public life, and economy around the globe. The repertoire of effective therapies for severe courses of the disease has remained limited. A large proportion of the world population suffers from vitamin D insufficiency or deficiency, with prevalence being particularly high among the COVID-19 high-risk populations. Vitamin D supplementation has been suggested as a potential option to prevent COVID-19 infections, severe courses, and deaths from the disease, but is not widely practiced. This article provides an up-to-date summary of recent epidemiological and intervention studies on a possible role of vitamin D supplementation for preventing severe COVID-19 cases and deaths. Despite limitations and remaining uncertainties, accumulating evidence strongly supports widespread vitamin D supplementation, in particular of high-risk populations, as well as high-dose supplementation of those infected. Given the dynamics of the COVID-19 pandemic, the benefit–risk ratio of such supplementation calls for immediate action even before results of ongoing large-scale randomized trials become available.

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“…With interest, we read the paper of Faniyi et al . [ 1 ], which investigated the relationship between vitamin D status and seroconversion for COVID-19 in UK healthcare workers. More specifically, vitamin D deficiency was an independent risk factor for the development of COVID-19 seroconversion, with the biggest differences seen in the Black Asian and minority ethnic (BAME) male group.…”

Section: To the Editormentioning

confidence: 99%

“…Although the study of Faniyi et al . [ 1 ] suggested that vitamin D deficiency is an independent risk factor for the development of COVID-19 seroconversion, with the biggest differences in the BAME male group, a recent, not yet peer-reviewed Mendelian randomisation study on vitamin D and COVID-19 susceptibility and severity in individuals of European ancestry, showed no protection of genetically increased 25(OH)D concentrations against COVID-19 susceptibility, hospitalisation, or severe disease. No evidence supports a protective role for vitamin D supplementation in COVID-19 outcomes.…”

Section: To the Editormentioning

confidence: 99%

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Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19

Speeckaert

Delanghe

2021

Eur Respir J

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With interest, we read the paper of Faniyi et al . [1], which investigated the relationship between vitamin D status and seroconversion for COVID-19 in UK healthcare workers. More specifically, vitamin D deficiency was an independent risk factor for the development of COVID-19 seroconversion, with the biggest differences seen in the Black Asian and minority ethnic (BAME) male group. Although several co-morbidities were taken into account, we would like to highlight the importance of vitamin D binding protein (DBP) and its polymorphism in the interpretation of low 25-hydroxyvitamin D [25(OH)D] levels in the BAME population with COVID-19.

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Vitamin D status and seroconversion for COVID-19 in UK healthcare workers

Cited by 31 publications

References 14 publications

Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review)

Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review)

Vitamin D Supplementation to Prevent COVID-19 Infections and Deaths—Accumulating Evidence from Epidemiological and Intervention Studies Calls for Immediate Action

Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19

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