Vitamin D Status as Related to Race and Feeding Type in Preterm Infants

Taylor, Sarah N.; Wagner, Carol L.; Fanning, Deanna; Quinones, Lakeya; Hollis, Bruce W.

doi:10.1089/bfm.2006.1.156

Cited by 19 publications

(13 citation statements)

References 38 publications

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“…Thus, repletion of vitD status during hospitalisation depends entirely on exogenous sources. There are limited recent reports on vitD intake in preterm infants during birth hospitalisation 9 10. Our study demonstrated that although total daily vitD intake from all sources increased progressively with age (data not shown), only 60% of this cohort of infants achieved an intake of 400 IU/day of vitD by 36 weeks PMA or at discharge.…”

Section: Discussioncontrasting

confidence: 53%

Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay

Monangi

Slaughter

Dawodu

et al. 2013

Arch Dis Child Fetal Neonatal Ed

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ObjectivesTo evaluate vitamin D (vitD) status in early preterm infants (EPTIs) at birth and during birth hospitalisation on current vitD intake.Design/methodsSerum 25-hydroxyvitamin-D [25(OH)D] concentrations, vitD intake and risk factors for low vitD status were assessed in 120 infants born at ≤32 weeks gestation.ResultsMean (SD) serum 25(OH)D at birth was 46.2 (14.0) nmol/L with lower concentrations in infants born <28 weeks than at 28–32 weeks gestation, p=0.02. Serum 25(OH)D was <50 nmol/L in 63% of mothers, 64% of infants at birth and 35% of infants at discharge. Mean daily vitD intake was 289±96 IU at 4 weeks of age and 60% achieved 400 IU/day intake at discharge.ConclusionsSerum 25(OH)D <50 nmol/L was widespread in parturient women and in EPTIs at birth and at discharge. Optimising maternal vitD status during pregnancy and improving postnatal vitD intake may enhance infant vitD status during hospitalisation.

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Section: Discussioncontrasting

confidence: 53%

Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay

Monangi

Slaughter

Dawodu

et al. 2013

Arch Dis Child Fetal Neonatal Ed

View full text Add to dashboard Cite

show abstract

“…This is especially important in cholestasis as vitamin D level is affected by malabsorption from biliary stasis. Monitoring vitamin D level is all the more important in black infants (constituted ~ 60% of our study population), as they have been reported to have significantly higher incidence of low vitamin D levels compared with white infants 28 , 29 . Studies in adults also observed racial differences in skeletal remodeling and bone mass and response to vitamin D 30 , 31 .…”

Section: Discussionmentioning

confidence: 75%

Metabolic Bone Disease

Viswanathan

Khasawneh

Dykstra

et al. 2013

J Parenter Enteral Nutr

111

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“…Vitamin D intake during the first year of life from milk or formula diet and supplemental foods has not been shown to consistently equal 400 IU/day, the amount recommended by the AAP or the IOM for term infants [ 31 , 32 ]. Preterm infants have a smaller size, leading to decreased volume intake, and often have a compromised nutritional status during the initial hospitalization and are even less likely to get adequate vitamin D intake from diet [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Randomized trial of two doses of vitamin D3 in preterm infants <32 weeks: Dose impact on achieving desired serum 25(OH)D3 in a NICU population

et al. 2017

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BackgroundRecommendations for vitamin D supplementation for preterm infants span a wide range of doses. Response to vitamin D supplementation and impact on outcomes in preterm infants is not well understood.ObjectiveEvaluate serum 25(OH)D3 concentration changes after 4 weeks in response to two different doses of vitamin D3 supplementation in a population of premature infants and quantify the impact on NICU outcomes.Design32 infants born at 24–32 weeks gestation were prospectively randomized to receive 400 or 800 IU/day vitamin D3 supplementation. Serum 25(OH)D3 levels were measured every 4 weeks. The Wilcoxon signed rank test was used to compare serum levels of 25(OH)D3 at 4 weeks and each subsequent time point. A p-value of <0.05 was considered statistically significant.ResultsSerum 25(OH)D3 levels at birth were 41.9 and 42.9 nmol/l for infants in the 400 IU group and 800 IU group, respectively (p = 0.86). Cord 25(OH)D3 concentrations significantly correlated with gestational age (r = 0.40, p = 0.04). After 4 weeks of D3 supplementation, median 25(OH)D3 levels increased in both groups (84.6vs. 105.3 nmol/l for 400 vs. 800 IU/day respectively, with significantly more improvement in the higher dose (p = 0.048). Infants in the 400 IU group were significantly more likely to have dual energy x-ray absorptiometry (DEXA) bone density measurements <10 percentile (56% vs 16%, p = 0.04).ConclusionsImprovement in 25(OH)D3 levels at 4 weeks, bone density, and trends towards improvement in linear growth support consideration of a daily dose of 800 IU of vitamin D for infants <32 weeks cared for in the NICU.

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Vitamin D Status as Related to Race and Feeding Type in Preterm Infants

Cited by 19 publications

References 38 publications

Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay

Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay

Metabolic Bone Disease

Randomized trial of two doses of vitamin D3 in preterm infants <32 weeks: Dose impact on achieving desired serum 25(OH)D3 in a NICU population

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