Vitamin D status as the major factor determining the circulating levels of parathyroid hormone: a study in normal subjects

Pepe, Jessica; Romagnoli, Elisabetta; Nofroni, Italo; Pacitti, M. T.; Geronimo, Simona De; Letizia, Claudio; Tonnarini, Gianfranco; Scarpiello, Addolorata; D'Erasmo, E; Minisola, Salvatore

doi:10.1007/s00198-004-1757-4

Cited by 77 publications

(57 citation statements)

References 38 publications

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“…A study conducted in postmenopausal women corroborates these findings, reporting no correlation between 25(OH)D and PTH at physiological concentrations (Villareal et al, 1991). Vitamin D only plays a role in the synthesis of PTH, whereas the secretion of the hormone is regulated primarily by calcium (Pepe et al, 2005;Zittermann et al, 1998). We speculate that no change in PTH concentrations was observed in this study as subjects had adequate dietary intakes of calcium, before supplementation with another 1500 mg calcium/day and were not severely deficient in vitamin D.…”

Section: Discussionmentioning

confidence: 80%

“…While Pepe et al (2005) suggested that 25(OH)D concentrations were the main factor determining the circulating levels of PTH, it has also been reported that PTH concentrations only rise when 25(OH)D concentrations are deficient and fall below 40 nmol/l (Mezquita-Raya et al, 2001;Jesudason et al, 2002). In the current study, we did not observe a direct association between 25(OH)D and PTH levels, and observed that even when 25(OH)D concentrations were very low (o30 nmol/l), PTH remained within normal reference ranges.…”

Section: Discussionmentioning

confidence: 99%

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Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

et al. 2006

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Objective: To assess the vitamin D status of healthy young people living in Northern Ireland and the effect of vitamin D supplementation on vitamin D status and bone turnover. Design: Double-blinded randomised controlled intervention study. Setting: University of Ulster, Coleraine, Northern Ireland. Subjects: In total, 30 apparently healthy students (15 male and 15 female subjects), aged 18-27 years, were recruited from the university, with 27 completing the intervention. Interventions: Subjects were randomly assigned, to receive either 15 mg (600 IU) vitamin D 3 and 1500 mg calcium/day (vitamin D group), or 1500 mg calcium/day (control group) for 8 weeks between January and March. Vitamin D status, bone turnover markers, serum calcium and parathyroid hormone concentrations were measured at baseline and post intervention.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

et al. 2006

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“…In healthy adolescents and adults, serum 25OHD concentration has been negatively correlated with serum PTH concentration. 4,6,38,47 This relationship between serum 25OHD and PTH concentrations has not been consistently reproduced in patients with IBD. In accordance with findings in healthy subjects, some investigators found a negative association of serum 25OHD concentration with serum PTH concentration in IBD patients.…”

Section: Discussionmentioning

confidence: 95%

Vitamin D Status in Children and Young Adults With Inflammatory Bowel Disease

Pappa¹,

Gordon

Saslowsky³

et al. 2006

Pediatrics

188

144

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OBJECTIVES-Previous studies of vitamin D status in pediatric patients with inflammatory bowel disease have revealed conflicting results. We sought to report (1) the prevalence of vitamin D deficiency (serum 25-hydroxy-vitamin D concentration ≤15 ng/mL) in a large population with inflammatory bowel disease, (2) factors predisposing to this problem, and (3) its relationship to bone health and serum parathyroid hormone concentration.PATIENTS AND METHODS-A total of 130 patients (8-22 years of age) with inflammatory bowel disease, 94 with Crohn disease and 36 with ulcerative colitis, had serum 25-hydroxyvitamin D, intact parathyroid hormone, and lumbar spine bone mineral density (using dual-energy x-ray absorptiometry) measured at Children's Hospital Boston. RESULTS-The prevalence of vitamin D deficiency was 34.6%. Mean serum 25-hydroxyvitamin D concentration was similar in patients with Crohn disease and ulcerative colitis, 52.6% lower among patients with dark skin complexion, 33.4% lower during the winter months (December 22 to March 21), and 31.5% higher among patients who were taking vitamin D supplements. Serum 25-hydroxy-vitamin D concentration was positively correlated with weight and BMI z score, disease duration, and serum albumin concentration and negatively correlated with erythrocyte sedimentation rate. Patients with Crohn disease and upper gastrointestinal tract involvement were more likely to be vitamin D deficient than those without it. Serum 25-hydroxyvitamin concentration was not associated with lumbar spine bone mineral density z score or serum parathyroid hormone concentration.CONCLUSIONS-Vitamin D deficiency is highly prevalent among pediatric patients with inflammatory bowel disease. Factors predisposing to the problem include having a dark-skin complexion, winter season, lack of vitamin D supplementation, early stage of disease, more severe disease, and upper gastrointestinal tract involvement in patients with Crohn disease. The long-term significance of hypovitaminosis D for this population is unknown at present and merits additional study. Copyright © 2006 by the American Academy of PediatricsAddress correspondence to Helen M. Pappa, MD, MPH, Division of Gastroenterology and Nutrition, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115. helen.pappa@childrens.harvard.edu. The authors have indicated they have no financial relationships relevant to this article to disclose. NIH Public Access Author ManuscriptPediatrics. Author manuscript; available in PMC 2011 November 1. Available reports on the vitamin D status of adults with CD place the prevalence of 25OHD concentration ≤15 ng/mL between 22% and 70%, depending on the study. 21-31 Serum 25OHD concentration was found to be <10 ng/mL in 8% to 45% of adults with CD. 21,22,24,26 One study reports a negative relationship among disease duration, Crohn Disease Activity Index, ferritin, C-reactive protein, cholesterol, 24 and 25OHD concentration.Other studies report that smoking 21 and small bowel resection 30,32 are also negativel...

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“…Vitamin D deficiency leads to reduced calcium absorption with a tendency towards hypocalcaemia, which stimulates PTH secretion. Thus, decreasing vitamin D leads to increasing levels of PTH (44). Increased PTH for longer periods of time may indeed have harmful effects on the cardiovascular system (7,45,46,47,48,49).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

Schierbeck

Rejnmark

Tofteng

et al. 2012

European Journal of Endocrinology

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Objective: To investigate the relationship between vitamin D status in healthy women and cardiovascular outcome. Design and methods : Between 1990: Between and 1993: Between , 2016 healthy, recently postmenopausal women were enrolled in the Danish Osteoporosis Prevention Study. Serum levels of 25-hydroxyvitamin D (25(OH)D, nmol/l) were measured at baseline. Participants were followed for 16 years. The primary end point was a combination of death, heart failure, myocardial infarction (MI) and stroke. Vitamin D deficiency was defined as serum 25(OH)D!50 nmol/l. The primary end point was adjusted for other risk factors of adverse cardiovascular events (age, smoking, blood pressure, hip-waist ratio, education and family history of MI).

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Vitamin D status as the major factor determining the circulating levels of parathyroid hormone: a study in normal subjects

Cited by 77 publications

References 38 publications

Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

Vitamin D Status in Children and Young Adults With Inflammatory Bowel Disease

Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

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