Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort

Bärebring, Linnea; Schoenmakers, Inez; Glantz, Anna; Hulthén, Lena; Jagner, Åse; Ellis, Joy; Bärebring, Mattias; Bullarbo, Maria; Augustin, Hanna

doi:10.3390/nu8100655

Cited by 52 publications

(86 citation statements)

References 25 publications

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“…The positive association between vitamin D intake from food and supplements and maternal VDD is in agreement with some [34,41,[43][44][45][46][47][48], but not all [39] of the previous studies. It appears that vitamin D intake from food and supplements contributed signi cantly to 25OHD level in population, in which sun exposure is minimum or dermal synthesis of 25OHD is limited.…”

Section: Discussionsupporting

confidence: 91%

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

Lee

Ling

Tusimin³

et al. 2020

Preprint

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Background Vitamin D deficiency (VDD) has been related to vitamin D binding protein (GC) gene polymorphism, demographics and lifestyle factors in different populations. However, previous studies examining the factors associated with VDD during pregnancy were restricted to the study of only demographics and lifestyle factors or genetic factors alone. Thus, this study assesses the associations of GC gene polymorphism, environmental and lifestyle factors with VDD in Malaysian pregnant women. Method: Information on demographics, dietary vitamin D intake from supplement and food, time spent outdoors, skin type and clothing were collected by questionnaire. Plasma total 25-hydroxyvitamin D (25OHD) levels were measured using Ultra-High-Performance Chromatography (UHPLC). Maternal GC single nucleotide polymorphisms (SNPs) (rs4588 and rs7041) were determined using restriction fragment length polymorphism (RFLP). Results Results showed that 50.2% of pregnant women were vitamin D deficient (25OHD < 30 nmol/L). VDD (25OHD < 30 nmol/L) were significantly associated with age, veiled clothing, maternal vitamin D intakes, both from food and supplement, and GC rs7041(and GC diplotypes). In contrast to previous studies in non-pregnant population, this study found that CC genotype for SNP GC rs7041, GC 1 s-1 s and GC If-2 were significantly associated with increased risk of VDD (25OHD < 30 nmol/L). Conclusions The high prevalence of maternal VDD reported in the present study suggests the need for urgent development and implementation of vitamin D supplementation or fortification strategies to reduce VDD among pregnant women. The discrepancy in the association of GC rs7041 with VDD reflects the differential in the factors associated with vitamin D deficiency in pregnancy compared to non-pregnant state

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Section: Discussionsupporting

confidence: 91%

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

Lee

Ling

Tusimin³

et al. 2020

Preprint

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“…Pregnant women from the population-based GraviD cohort in the south-west of Sweden were included in this study. The cohort has been described in detail elsewhere [19]. In brief, 2125 women were included in the cohort when registering for antenatal care during autumn 2013 and spring 2014.…”

Section: Recruitment and Inclusionmentioning

confidence: 99%

Poor Dietary Quality Is Associated with Low Adherence to Gestational Weight Gain Recommendations among Women in Sweden

2020

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Appropriate gestational weight gain (GWG) is important for fetal development and maternal health, but it is unclear what dietary factors predict GWG. The aim of this study was to investigate the association between dietary quality during pregnancy and GWG. In total, 1113 pregnant women were recruited when registering for antenatal care. GWG was defined according to the Institute of Medicine (IOM) guidelines. GWG was calculated as measured body weight at registration for antenatal care, to gestational week 37 ± 2. Dietary intake was assessed using a food frequency questionnaire (FFQ) administered in gestational week >31. In total, 40% gained within the IOM GWG recommendations, 25% had insufficient GWG and 35% excessive GWG. Women with a poor or fair quality diet gained approximately 2 kg more than women with a high-quality diet. Poor dietary quality was also associated with higher odds of excessive GWG, due to fat quality and intake of discretionary foods. In conclusion, poor quality dietary intake is associated with lower adherence to the guidelines on weight gain in pregnancy. A diet characterised by high-quality fat intake, low consumption of discretionary foods and high nutrient intake may promote healthy weight gain and prevent excessive GWG.

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“…In children, severe VDD additionally causes hypocalcaemia (low levels of calcium in the blood), which is associated with seizures, tetany and heart failure (4,5), and rickets with osteomalacic leg bowing, muscle weakness and delayed infant development. Morbidity from VDD is predominantly found in individuals from Black and Asian Minority Ethnic (BAME) groups living in high-latitude countries, including in the UK (6,7), the US (8), Canada (9), Scandinavian countries (10)(11)(12)(13) and Australia (8,14). Nonetheless, VDD is common in many populations across the world, regardless of ethnicity.…”

Section: Introductionmentioning

confidence: 99%

“…Evidence shows that vitamin D status, which is measured through the blood concentration of a Vitamin D metabolite, the 25-hydroxyvitamin D [25(OH)D], is suboptimal in 13% of the European population (21). In the UK population, 20% of adults and 16% of children aged between 11 and 18 years are estimated to be VDD (2), with the BAME group being, by far, the most affected (10,12,(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

The economic case for prevention of population vitamin D deficiency: a modelling study using data from England and Wales

et al. 2019

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Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort

Cited by 52 publications

References 25 publications

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

Poor Dietary Quality Is Associated with Low Adherence to Gestational Weight Gain Recommendations among Women in Sweden

The economic case for prevention of population vitamin D deficiency: a modelling study using data from England and Wales

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