Vitamin D status in adult critically ill patients in Eastern India: An observational retrospective study

Padhi, Rajesh Kumar; Panda, Baikunthanath; Jagati, Snehalata; Patra, Subhas Chandra

doi:10.4103/0970-2113.135755

Cited by 11 publications

(8 citation statements)

References 22 publications

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“…A number of studies on critically ill inpatients in the ICUs have reported consistent findings including Amrein and colleagues who reported that low 25(OH) D status is significantly associated with mortality in the critically ill [24]; Braun and colleagues reported deficiency of 25-hydroxyvitamin D at the time of critical care initiation is a significant predictor of all-cause patient mortality in a critically ill patient population [25]; Zhao and colleagues reported concentrations of 25(OH)D were inversely associated with allcause and cardiovascular diseases mortality among adults with hypertension in the US. Enhancing vitamin D intake may contribute to a lower risk for premature death; and finally Braun and colleagues [26] reported association of low serum 25-hydroxyvitamin D levels and acute kidney injury in the critically ill patients [27].…”

Section: Resultsmentioning

confidence: 99%

Serum vitamin D level was not associated with severity of ventilator associated pneumonia

Yaghoobi

Taher

Seifrabie

et al. 2019

Romanian Journal of Internal Medicine

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Background and Objective. Vitamin D deficiency is considered one of the most common nutritional deficiencies associated with weakened immune system and increased likelihood of sepsis. The current study was conducted to investigate the association between serum vitamin D level and the severity and prognosis of ventilator associated pneumonia (VAP) in inpatients in intensive care unit (ICU). Methods. Eighty-four consecutive patients with VAP were enrolled in this observational, prospective study conducted in the ICU of Besat Hospital, Hamadan. The patients were examined for serum 25-hydroxyvitamin D (vitD3) level and VAP severity and prognosis. Clinical pulmonary infection score was used for the diagnosis, and Sequential Organ Failure Assessment (SOFA) Score was used to determine the severity of VAP. Results. Low level serum vitD3 (under 30 ng/mL) was found in 66 (78.6%) patients. In this series of VAP patients, there were no significant differences in blood culture results, 14 and 28-day sepsis-associated mortality, mechanical ventilation duration, or SOFA Score on days 3, 7, and 14 between the low level and normal level vitD3 patients (p > 0.05). Conclusion. Serum vitD3 level was not associated with mortality from VAP or complications due to sepsis in the inpatients in the ICU.

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Section: Resultsmentioning

confidence: 99%

Serum vitamin D level was not associated with severity of ventilator associated pneumonia

Yaghoobi

Taher

Seifrabie

et al. 2019

Romanian Journal of Internal Medicine

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“…48 In noncritically ill subjects, 25(OH)D deficiency has been associated with chronic obstructive pulmonary disease and respiratory symptoms. 50 In retrospective and prospective observational studies of ICU patients, 25(OH)D levels were inversely associated with mechanical ventilation days in medical ICU patients (10.04 6 1.97 days in vitamin D-deficient group vs. 3.15 6 0.15 days in vitamin D sufficient group, P 5 0.003) 45 and critically ill surgical patients (incident risk ratio per 10 ng/mL 5 0.66, 95% CI 5 0.39-0.66, P , 0.05) 48 ; however, in another study, there was no observed association between vitamin D deficiency and mechanical ventilation. 42 …”

Section: Respiratorymentioning

confidence: 98%

Outcomes of Vitamin D Supplementation in Adults Who are Deficient and Critically Ill: A Review of the Literature

Williams

Heuberger

2016

American Journal of Therapeutics

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Vitamin D deficiency is known to be common in the general population and has been linked to all-cause mortality. The classically recognized role of vitamin D is its involvement in calcium and phosphorous homeostasis and bone health. Recent evidence suggests that vitamin D may also play a role in other nonskeletal processes, such as anti-proliferation, immunity, regulation of hormone section, and muscle strength. An extensive literature review of vitamin D and critical illness from 2000 to 2015 (PubMed and CINAL) produced multiple observational studies revealing a high prevalence of vitamin D deficiency in intensive care patients. Many of these studies have indicated that there is an association between vitamin D deficiency and clinical outcomes such as mortality, sepsis, duration of mechanical ventilation, and length of stay. This review article provides an overview of vitamin D physiology in adults, a summary of observational studies on vitamin D deficiency in critical illness, and an examination of the few clinical trials on vitamin D supplementation in intensive care patients.

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“…The prevalence of vitamin D deficiency in intensive care ranges typically between 40 and 70%. 47,[75][76][77][78][79] Lee was the first to publish that vitamin D deficiency in the ICU is a common problem, based on data from 42 patients referred for endocrinologic evaluation. 80 This finding has been replicated and extended worldwide.…”

Section: Epidemiologymentioning

confidence: 99%

Metabolic and Endocrine Challenges

Bonicolini

Parekh

Thein

et al. 2020

Semin Respir Crit Care Med

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This review aims to provide an overview of metabolic and endocrine challenges in the setting of intensive care medicine. These are a group of heterogeneous clinical conditions with a high degree of overlap, as well as nonspecific signs and symptoms. Several diseases involve multiple organ systems, potentially causing catastrophic dysfunction and death. In the majority of cases, endocrine challenges accompany other organ failures or manifest as a complication of prolonged intensive care unit stay and malnutrition. However, when endocrine disorders present as an isolated syndrome, they are a rare and extreme manifestation. As they are uncommon, these can typically challenge both with diagnosis and management. Acute exacerbations may be elicited by triggers such as infections, trauma, surgery, and hemorrhage. In this complex scenario, early diagnosis and prompt treatment require knowledge of the specific endocrine syndrome. Here, we review diabetic coma, hyponatremia, hypercalcemia, thyroid emergencies, pituitary insufficiency, adrenal crisis, and vitamin D deficiency, highlighting diagnostic tools and tricks, and management pathways through defining common clinical presentations.

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Vitamin D status in adult critically ill patients in Eastern India: An observational retrospective study

Cited by 11 publications

References 22 publications

Serum vitamin D level was not associated with severity of ventilator associated pneumonia

Serum vitamin D level was not associated with severity of ventilator associated pneumonia

Outcomes of Vitamin D Supplementation in Adults Who are Deficient and Critically Ill: A Review of the Literature

Metabolic and Endocrine Challenges

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