Vitamin D Status in Children With Short Stature: Accurate Determination of Serum Vitamin D Components Using High-Performance Liquid Chromatography–Tandem Mass Spectrometry

Xu, Bei; Feng, Yue; Gan, Lingling; Zhang, Yamei; Jiang, Wenqiang; Feng, Jiafu; Lin, Yan‐Hui

doi:10.3389/fendo.2021.707283

“…One of those researches found that consuming calcium below a specific cutoff value could affect final body height, while increasing calcium intake above the cutoff value didn't increase final body height but increased the body height's growth rate. Some researchers also found that calcium intake didn't correlate with body height (Maharsari, 2018;Winzenberg et al, 2007;Xu et al, 2021). This could happen because calcium has 40-60% absorption rate depending on some factors, like the concentration of calcium ions in the gastrointestinal (GIT) lumen, absorption time of the food in the GIT, and substances that could inhibit calcium absorption, such as phytate and oxalate (Shkembi & Huppertz, 2022).…”

Section: Discussionmentioning

confidence: 99%

Relationship of mid-parental height, Calcium intake, and intensity of physical activity with body height growth of high school students in Malang

Firdaus

¹

,

Illahika

²

,

Hanifwati

³

et al. 2023

Qanun Medika

0

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Stunting is one of Indonesia's problems, as portrayed in RISKESDAS 2018. This means the growth of Indonesian children was not optimal. Some factors that might affect body height growth were genetic factors, represented by mid-parental height, nutritional factors, especially calcium, and physical activity, which could activate pathways to stimulate growth. These factors were known to have a huge role in body height growth, especially if these factors were optimized in adolescence, as in high school students. This research aimed to explain the relationship between body height growth and the factors that might affect it: mid-parental height, calcium intake, and the intensity of physical activity. This research was observational analytic, using purposive sampling as the sampling method and collecting data using a cross-sectional questionnaire. Statistical analysis between variables shows that mid-parental height was positively related (p<0.05, r: 0,356), while calcium supplementation was not associated (p<0.05, r: -0.165), and intensity of physical activity was not related (p=0.059, r: 0.089) with the body height growth of the students. In conclusion, among the factors that were analyzed, mid-parental height was the only one that had a relationship with body height growth.

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“…From then on, increasing studies have focused on the relationship between C3-epi-25(OH)D and disease or health [24,32,33]. However, most of these have been 5 Oxidative Medicine and Cellular Longevity limited to the VitD storage overestimation, ignoring the role of C3-epi-25(OH)D in disease progression [34,35], and thus failing to provide a more reasonable explanation for the abnormal increase of C3-epi-25(OH)D in pathological conditions. Therefore, this study focused on the difference in C3-epi-25(OH)D levels in RA patients with different severities of CKD and aimed to understand the potential connections between the two.…”

Section: Discussionmentioning

confidence: 99%

C3-Epimer of 25-Hydroxyvitamin D3 as a Superior Marker for Predicting the Severity of Chronic Kidney Disease in Rheumatoid Arthritis Patients

Tang

¹

,

Ying

²

,

Yang

³

et al. 2022

Oxidative Medicine and Cellular Longevity

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Objective. 25-hydroxyvitamin D3 (25[OH]D3) is involved in oxidative stress regulation by upregulating the expression of antioxidant genes except for mineral homeostasis physiological role. C3-epimer of 25(OH)D3 (C3-epi-25[OH]D3) is a form of vitamin D metabolite with low bioaffinity in vivo, but little is known about the relationship between C3-epi-25(OH)D3 and diseases. This study was aimed at investigating the relationship between C3-epi-25(OH)D3 and the severity of chronic kidney disease (CKD) in patients with rheumatoid arthritis (RA). Method. A total of 318 RA inpatients were enrolled and divided into mild ( n = 247 ), moderate ( n = 46 ), and severe ( n = 25 ) CKD groups according to the CKD prognosis criterion of the Kidney Disease Improving Global Outcomes guidelines. Serum levels of 25(OH)D2, 25(OH)D3, C3-epi-25(OH)D3, and free 25(OH)D (F25[OH]D) were measured, and the value of 25(OH)D was calculated. The relationship and changing trend of the indexes based on CKD severity were analyzed. Results. The serum levels of 25(OH)D, 25(OH)D3, and F25(OH)D showed a decreasing trend ( z = − 2.781 – − 3.996 , P < 0.01 ) in RA patients with CKD progression from mild to severe, while C3-epi-25(OH)D3 showed an increasing trend ( z = 6.741 , P < 0.001 ) and 25(OH)D2 showed no significant difference among the groups ( z = 0.976 , P = 0.329 ). Only levels of C3-epi-25(OH)D3 presented significant differences between adjacent CKD severity groups in RA patients (mild to moderate: z = 3.963 , P a d j < 0.001 ; moderate to severe: z = 3.269 , P a d j = 0.002 ). Multiple logistic regression analysis showed that 25(OH)D3 and C3-epi-25(OH)D3 were significant predictors for CKD progression in RA patients, and C3-epi-25(OH)D3 had a better predictive advantage (moderate vs. mild: OR = 4.79 , P < 0.001 ; severe vs. mild: OR = 17.85 , P < 0.001 ). Conclusions. To the best of our knowledge, this is the first study to reveal that C3-epi-25(OH)D3 is a dominant predictor of CKD severity in RA patients. Further studies are needed to explore the relationship between C3-epi-25(OH)D3 and other diseases.

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“…The vitamin K and vitamin D levels in serum were assessed by high-performance liquid chromatography (HPLC) (34)(35)(36). Briefly, 2 ml of venous blood was collected in a standard biochemical tube (red cap tube) and stored at room temperature while being protected from light.…”

Section: Serum Vitamin K /K and (Oh)d Concentrationsmentioning

confidence: 99%

The mediation effect of vitamin A and vitamin D supplement in the association between serum vitamin K levels and musculoskeletal disorders in preschool children

Ge,

Zhang,

Sun

et al. 2023

Front. Nutr.

0

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IntroductionVitamin K deficiency may elevate the incidence of musculoskeletal disorders (MSD), whereas it lacks validation for pediatric populations and has uncertain dose recommendations. In this context, we hypothesized that serum vitamin K levels are associated with MSD in preschool children, and the widely used vitamin A and vitamin D supplements may mediate these associations based on potential mechanisms, which expects to provide guidance for future practice.MethodsA cross-sectional study was conducted in Sichuan province in southwestern China, from January 2021 to May 2022. Serum levels of vitamin K1/K2 and 25(OH)D were determined using the high-performance liquid chromatography method, and the diagnosis of MSD was executed by clinicians. Overall and stratified logistic regression analysis based on categorized 25(OH)D levels were conducted to assess association between serum vitamin K levels and MSD prevalence after adjusting for confounders. Mediation analysis was further performed and vitamin A and D supplementation was regressed as the mediator.ResultsA total of 6,368 children aged 0–6 years old were enrolled. MSD was identified in 1179 (18.51%) of the children, while 5,189 (81.49%) of them did not present such disorder. After adjusting confounders, a significant difference was found in serum vitamin K1 level between children in MSD and Non-MSD group (OR = 0.802, 95%CI 0.745–0.864). No significant difference was found in serum vitamin K2 level between the two groups (OR = 0.975, 95%CI 0.753–1.261). The association between vitamin K1 level and MSD prevalence was partly (36.8%) mediated by vitamin A and D supplementation.ConclusionsA low serum vitamin K1 level is connected with an increased risk of MSD among children, highlighting that vitamin A and D supplementation is a helpful intervention to prevent MSD in children with vitamin K deficiency.

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Vitamin D Status in Children With Short Stature: Accurate Determination of Serum Vitamin D Components Using High-Performance Liquid Chromatography–Tandem Mass Spectrometry

Cited by 14 publications

References 45 publications

Relationship of mid-parental height, Calcium intake, and intensity of physical activity with body height growth of high school students in Malang

Relationship of mid-parental height, Calcium intake, and intensity of physical activity with body height growth of high school students in Malang

C3-Epimer of 25-Hydroxyvitamin D3 as a Superior Marker for Predicting the Severity of Chronic Kidney Disease in Rheumatoid Arthritis Patients

The mediation effect of vitamin A and vitamin D supplement in the association between serum vitamin K levels and musculoskeletal disorders in preschool children

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