Vitamin D status in children with Hashimoto thyroiditis

Çamurdan, Orhun; Döğer, Esra; Bıdecı, Aysun; Çelik, Nurullah; Cınaz, Peyami

doi:10.1515/jpem-2012-0021

Cited by 58 publications

(60 citation statements)

References 9 publications

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“…Our results stay in accordance with previously published articles (according to the PubMed database) on vitamin D concentration in HT patients [19][20][21][22][23] ( Table 1). Effraimidis et al's paper contradicts these findings to a certain extent, as they found no significant difference in vitamin D status between the group at an early stage of thyroid autoimmunity (recent diagnosis of raised TPOAb concentration) and the controls [24].…”

Section: Discussionsupporting

confidence: 93%

Assessment of Vitamin D Level in Autoimmune Thyroiditis Patients and a Control Group in the Polish Population

Maciejewski¹,

Wójcicka²,

Roszak³

et al. 2015

Adv Clin Exp Med

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Background. Vitamin D, known for its role in calcium-phosphorus homeostasis, is also a significant immunomodulatory factor. Vitamin D deficiency has been reported in some autoimmune disorders. Recently, vitamin D level in autoimmune thyroiditis (HT -Hashimoto's thyroiditis) has become the subject of researchers' interest. Objectives. This study aims to assess vitamin 25-OH-D3 levels in HT patients in comparison to a control group in the Polish population. This would be the first attempt conducted in this region with such poor sunlight exposure. Material and Methods. The group we studied consisted of 62 subjects diagnosed with HT (mean age 49.15 ± 15.51) and 32 healthy controls matched with age and sex (mean age 46.09 ± 14.32). All blood samples were collected in the first quarter of the year to minimize the impact of seasonal fluctuations of vitamin D concentrations. Results. In the HT group the mean vitamin D level was 20.09 nmol/L (SD ± 12.66), compared to 30.31 nmol/L (SD ± 19.49) in the controls, p = 0.014. None of the patients and the controls was vitamin D sufficient (75-125 nmol/L). The deficiency (< 50 nmol/L) was significantly more common among HT patients compared to the controls (61-98.4% vs. 27-84.4%, p = 0.029). Conclusions. In conclusion, we found that serum vitamin D concentration is significantly lower in HT patients in comparison to the control group. This suggests vitamin D deficit as one of the risk factors for HT development. Observed vitamin D level was also low in the control group, therefore wider supplementation in general population should be recommended (Adv Clin Exp Med 2015, 24, 5, 801-806).

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Section: Discussionsupporting

confidence: 93%

Assessment of Vitamin D Level in Autoimmune Thyroiditis Patients and a Control Group in the Polish Population

Maciejewski¹,

Wójcicka²,

Roszak³

et al. 2015

Adv Clin Exp Med

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“…Camurdan et al reported that vitamin D deficiency was nearly four times more prevalent and 25(OH)D levels were significantly lower (31.2±11.5 nmol/L) in 78 children with Hashimoto's thyroiditis (hypothyroidism, 6.4%; subclinical hypothyroidism, 15.4%, euthyroidism, 78.2%) compared to controls (n=74, 57.9±19.7 nmol/L) (conversion factor for 25(OH) D: ng/mL=nmol/L/2.496). 8 In agreement with our findings, a longitudinal follow-up of adult subjects revealed that prevalence of vitamin D deficiency comparable between cases who developed TPOAb during follow-up compared to those who did not, resulting in the suggestion that vitamin D deficiency is not associated with early thyroid autoimmunity. 36 In conclusion, the present study demonstrated that a subset of cases with type 1 diabetes and autoimmune thyroiditis have elevated IgG4 levels, suggesting existence of IgG4 thyroiditis.…”

Section: Discussionsupporting

confidence: 91%

“…7 Recently, children and adults with Hashimoto's thyroiditis were found to have significantly lower 25(OH) vitamin D [25(OH)D] levels and higher frequency of vitamin D deficiency compared to controls. [8][9][10] On the other hand, the role of vitamin D levels in Hashimoto's thyroiditis accompanying type 1 diabetes, for which deficiency of vitamin D and genetic variations in vitamin D-related genes were proposed as being predisposing factors, has not yet been investigated. 11 Recently, in adults who required total thyroidectomy, a subtype of Hashimoto's thyroiditis was described, termed "IgG4 thyroiditis", which is characterized by an abundance of IgG4-positive plasma cells and fibrosis in the thyroid tissue, lower female/male ratio, higher percentage of diffuse low echogenicity at ultrasonography, more rapid clinical progression, and higher serum levels of IgG4 and thyroid autoantibodies.…”

mentioning

confidence: 99%

Autoimmune thyroiditis in children and adolescents with type 1 diabetes mellitus is associated with elevated IgG4 but not with low vitamin D

Demir

Keskın

Kör

et al. 2014

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ObJEcTIVE: To assess levels of vitamin D and of immunoglobulin G subclasses in children and adolescents with type 1 Diabetes Mellitus with or without autoimmune thyroiditis. DE-SIGN: Among 213 patients with type 1 diabetes, the cases with thyroid-specific autoantibodies formed Group 1 [n=19, M/F: 7/12, median age 13 years (10.1-14.7)]. Nineteen age-, gender-, and diabetes duration-matched cases with type 1 diabetes without any other systemic disease were designated as controls [Group 2, M/F: 7/12, median age 12.9 years (10.5-14.9)]. rESULTS: Levels of thyroid hormones, vitamin D, total IgG and IgG subclasses, as well as IgG subclasses/ total IgG ratios were similar between the groups. Five cases (26%) in Group 1 had IgG4 levels > + 2 SDS, whereas there were no such cases in Group 2 (p=0.046). These five patients had similar clinical features but higher median IgG4 levels and IgG4/Total IgG ratios compared to the subjects with IgG4 levels < + 2 SDS in Group 1 and Group 2. cONcLUSIONS: There was no difference of vitamin D levels between the groups. Only a small percentage of patients with type 1 diabetes also having autoimmune thyroiditis had elevated serum IgG4 levels, revealing the heterogeneity of autoimmune thyroiditis and existence of IgG4 thyroiditis in the pediatric age group. Total IgG, the other IgG subclasses, and vitamin D levels did not differ in patients with autoimmune thyroiditis and type 1 diabetes compared to those suffering only from type 1 diabetes.

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“…Vitamin D directly regulates T lymphocyte functions by inhibiting the proliferation of Th1 cells and increasing the number of Th2 cells (8). Vitamin D also suppresses the production of IL-2, IL-5, IFN-c, and TNF-a, and increases the production of IL-4 and transforming growth factor in Th2 cells (12).…”

Section: Discussionmentioning

confidence: 99%

“…However, it is unclear whether low vitamin D levels closely correlate with the development of autoimmune thyroid disease (AITD). Small case-control studies have suggested lower serum vitamin D levels or a higher prevalence of vitamin D insufficiency in patients with AITD compared with healthy controls (11)(12)(13)(14)(15)(16). However, another study reported no significant association between the serum vitamin D levels and thyroid autoimmunity (17).…”

Section: Introductionmentioning

confidence: 99%

Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

Choi

Kim

et al. 2014

Thyroid

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Background: Low serum vitamin D levels have been associated with several autoimmune diseases, but their association with thyroid autoimmunity is unclear. We evaluated the association of serum vitamin D levels with the prevalence of autoimmune thyroid disease (AITD). Methods: Our cross-sectional study included subjects who underwent routine health checkups, which included assays of serum 25-hydroxy vitamin D3 [25(OH)D3] and anti-thyroid peroxidase antibody (TPO-Ab), as well as thyroid ultrasonography (US) between 2008 and 2012 at the Asan Medical Center. We defined AITD according to the levels of TPO-Ab and US findings. Results: A total of 6685 subjects (58% male; 42% female) were enrolled for this study. Overall prevalence of TPO-Ab positivity and both TPO-Ab/US positivity were 10.1% (6.3% male; 15.3% female) and 5.4% (2.3% male; 9.7% female) respectively. In female subjects, mean serum 25(OH)D3 levels were significantly lower in the TPO-Ab(+) (22.0 vs. 23.5 ng/mL, p = 0.030) and TPO-Ab(+)/US(+) groups (21.6 vs. 23.4 ng/mL, p = 0.027) compared with the control group, respectively. According to the levels of serum 25(OH)D3, the prevalence of TPO-Ab positivity (21.2%, 15.5%, and 12.6% in deficient, insufficient, and sufficient group, respectively; p = 0.001) and both TPO-Ab and US positivity (14.7%, 9.9%, and 7.1% in deficient, insufficient, and sufficient group, respectively; p < 0.001) decreased in female subjects. Interestingly, this pattern was significant only in pre-menopausal women ( p = 0.003 and p < 0.001; respectively), but not in postmenopausal women. Multivariate analysis indicated that the adjusted odds ratios (

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Vitamin D status in children with Hashimoto thyroiditis

Cited by 58 publications

References 9 publications

Assessment of Vitamin D Level in Autoimmune Thyroiditis Patients and a Control Group in the Polish Population

Assessment of Vitamin D Level in Autoimmune Thyroiditis Patients and a Control Group in the Polish Population

Autoimmune thyroiditis in children and adolescents with type 1 diabetes mellitus is associated with elevated IgG4 but not with low vitamin D

Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

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