Vitamin D status in diabetic patients (type 2) and its relation to glycemic control &amp; diabetic nephropathy

Ali, Mayssa I.; Fawaz, Lubna; Sedik, Eman; Nour, Zeinab A.; El-Sayed, Rokaya

doi:10.1016/j.dsx.2019.04.040

Cited by 11 publications

(8 citation statements)

References 10 publications

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“…Overall, most of the data presented here suggest a pivotal role of VD in the regulation of insulin secretion and confirm that the decreased insulin sensitivity at target organs may be attributable to VD inadequacy [67]. The relationship between VD deficiency and IR could be realized at the level of modulation of immune processes and inflammation, since VD deficiency is associated with an increase in inflammatory markers.…”

Section: Vitamin D Deficiency and Type 2 Diabetes Mellitussupporting

confidence: 68%

Vitamin D Deficiency and Diabetes Mellitus

Shymanskyi¹,

Lisakovska²,

Mazanova³

et al. 2020

Vitamin D Deficiency

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Vitamin D (VD) is a molecule that can be synthesized directly in the humans' body or enter the organism with food in the form of inactive precursors. To exert its biological action, VD undergoes two-stage hydroxylation (at the 25th and 1st position) catalyzed by cytochromes P450, the presence of which has already been shown in almost all tissues of the human body. The product of hydroxylation is hormone-active form of vitamin D-1,25(OH) 2 D. 1,25(OH) 2 D binds to specific vitamin D receptor (VDR) and regulates the expression of genes involved in bone remodeling (classical function) and genes that control immune response, hormone secretion, cell proliferation, and differentiation (nonclassical functions). VD deficiency is prevalent around the globe and may be one of the key factors for diabetes development. The direct association between vitamin D deficiency and type 1 (T1D) and type 2 (T2D) diabetes has been proven. Detection of VDR in pancreas and adipose tissue, skeletal muscles, and immune cells allowed implying the antidiabetic role of vitamin D by enhancing insulin synthesis and exocytosis, increasing the expression of the insulin receptor, and modulating immune cells' functions. This chapter summarizes data about relationship between VD insufficiency/deficiency and development of T1D and T2D, and their complications.

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Section: Vitamin D Deficiency and Type 2 Diabetes Mellitussupporting

confidence: 68%

Vitamin D Deficiency and Diabetes Mellitus

Shymanskyi¹,

Lisakovska²,

Mazanova³

et al. 2020

Vitamin D Deficiency

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“…Experiments with vitamin D are aimed at population groups with 25(OH)D deficiency and some pathologies, such as diabetes, hypertension, insulin resistance, musculoskeletal disorders, cardiovascular disease, and kidney disease, as there is an association between low vitamin D levels and an increased risk of developing and worsening cardiovascular disease 59 , different types of cancers 60 , diabetes 61 , autoimmune diseases 62 , and overall mortality 63 . In addition, studies which used lower dosages of cholecalciferol were performed for periods longer than 2 months.…”

Section: Discussionmentioning

confidence: 99%

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

Medeiros

Borges

Soares

et al. 2020

Sci Rep

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Vitamin D supplementation is widely used. However, there is no consensus on the use and dosage of this supplement and the existing recommendations arise from studies based on the benefits that this nutrient can facilitate in bones. In addition, individual genetics can influence the response to supplementation, therefore, research involving monozygotic twins aims to reduce these differences in phenotypic responses. The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRnA. An intervention was performed through supplementation with cholecalciferol at the concentration of 2000 IU in 90 healthy adult monozygotic twins (male or female pairs) for 2 months. The findings showed that serum vitamin D concentration increased by 65% and VDR gene expression sixty times (p = 0.001). Changes in body composition parameters were observed regarding body fat and lean mass. our results indicate that an increase in serum vitamin D concentration may have potential therapeutic implications. Supplementation with vitamin D (cholecalciferol) has become a widely used practice, since a relationship has been demonstrated of low levels of this nutrient with the increased risk of cardiovascular diseases, the recurrence of diseases, and mortality 1,2,3. However, as there is no consensus on sufficient serum levels of vitamin D, taking into account its non-skeletal functions, it is necessary to assess whether the increase in this nutrient in individuals with 25-hydroxyvitamin D (25 (OH) D) levels above the current cutoff point, generates any health benefits 4. Vitamin D is involved in several non-skeletal functions, such as cell regulation, differentiation, and growth 3 , and adaptive and innate immunity control 5 , as well as being associated with inflammatory markers 6 , since the vitamin D receptor (VDR) is expressed in almost all human cells 7. The activity of this nutrient in the human organism involves its binding with VDR 8 , whose expression is modulated by the blood levels of the 1,25diidroxivitamin D (1,25 (OH) 2D) 9 and genetic variants 10. It is believed that there is a negative correlation between the concentration of 25 (OH) D with the body mass index (BMI) and percentage of fat mass 11. However, few studies have comprehensively evaluated the effect of

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“…Multiple studies have demonstrated that the prevalence of 25(OH)D 3 deficiency was significantly higher in diabetic groups (both T1DM and T2DM) compared to healthy controls [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Type 1 diabetic patients had lower 25(OH)D 3 concentrations compared to healthy controls [ 30 ], a phenomenon that was also observed in type 2 diabetics [ 32 ]. Complementary to these results, a significant negative correlation was observed between 25(OH)D 3 concentrations and HbA1c (r = −0.277, p < 0.0001) [ 34 ].…”

Section: Human Studiesmentioning

confidence: 99%

The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach

Delrue

Speeckaert

Delanghe

et al. 2022

IJMS

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According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach.

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Vitamin D status in diabetic patients (type 2) and its relation to glycemic control & diabetic nephropathy

Cited by 11 publications

References 10 publications

Vitamin D Deficiency and Diabetes Mellitus

Vitamin D Deficiency and Diabetes Mellitus

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach

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