Vitamin D status in patients with rheumatoid arthritis: a correlation analysis with disease activity and progression, as well as serum IL-6 levels

Polasik, Kinga; Piotrowska, Ewa; Lipińska, Barbara; Witkowski, Jacek M.; Bryl, Ewa; Tukaj, Stefan

doi:10.18388/abp.2017_1636

Cited by 17 publications

(21 citation statements)

References 24 publications

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“…Another longitudinal study demonstrated that D vitamin levels were associated with disease activity, fatigue, and morning stiffness, but any effect of vitamin D levels on radiographic damage was not shown [17]. Polasik et al [5], also found no significant association among the vitamin D levels and either disease activity and radiologic damage in the RA participants. Finally, the other two studies showed that while lower vitamin D levels were related with disease activity, not related with radiological structural damage in RA [1,24].…”

Section: Discussionmentioning

confidence: 95%

“…Another interesting issue is whether vitamin D has an inverse relation with RA activity. The evidence from various studies concerning the link between serum vitamin D concentration and disease activity is inconsistent [5][6][7]. Some studies also revealed that the impact of inadequate vitamin D levels on disease activity in the RA individuals was associated with more subjective variables (eg, Visual Analog Scale (VAS) pain, tender joint count (TJC)) than a real objective immunomodulatory effect [8].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

Uçkun

Yurdakul

Kılıçarslan

et al. 2018

Archives of Clinical and Experimental Medicine

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In this study, our aims were to identify vitamin D levels in rheumatoid arthritis (RA) individuals as compared to controls and the impact of vitamin D levels on both objective and subjective assessments in RA patients. Methods: The current study was a prospective case-control study conducted on 108 RA patients and 50 agegender matched healthy controls. We first compared the levels of vitamin D among the RA patients and controls. Demographic and clinical data, parameters of disease activity, inflammatory markers, rheumatoid factor and anti-cyclic citrullinated peptide seropositivity and radiological damage scores were recorded in RA patients. These patients were also demanded to complete RA Quality of Life Questionnaire (RAQoL), fatigue severity scale (FSS) and Health Assessment Questionnaire (HAQ). Results: D vitamin levels in RA patients were significantly lower than healthy controls (p=0.001). Vitamin D deficiency was determined in 73% of the RA patients and 52% of the controls. Vitamin D deficiency was not associated with disease activity (p=0.862). There was no significant relationship among vitamin D levels and all subjective and objective assessments (p>0.05 for all). Conclusion: Vitamin D deficiency was common in RA participants than normal population. However, it was not shown that there was a significant relationship between vitamin D levels and objective and subjective assessments of disease, including disease activity, inflammatory markers, rheumatoid factor and anti-cyclic citrullinated peptide seropositivity, radiological damage scores, RAQoL, FSS and HAQ.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

Uçkun

Yurdakul

Kılıçarslan

et al. 2018

Archives of Clinical and Experimental Medicine

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“…The pathological damage was complex and involved many cells, including macrophages, osteoblasts, synovial cells, macrophages which were the focus [ 13 , 14 ]. The abnormal hyperplasia and inflammation secretion of synovial cells in rheumatoid arthritis have recently been noticed [ 15 , 16 ]. In this study, we chose the FLS cells as the cell model and UHMWPE as the test substance to observe the effect of UHMWPE on cell activity, inflammatory factor secretion, and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

The Role of IL-6RA in UHMWPE Promotes Proliferation in Fibro-Like Synovial Cells

Pang

Jiang

Zhen

et al. 2018

BioMed Research International

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UHMWPE granule could induce macrophages and inflammatory responses in interfacial tissues, which eliminated the wear debris of UHMWPE component and further induced dissolution of the surrounding bone, leading aseptic loosening. However, the mechanism of synovial cells, especially fibroblast-like synovial (FLS) cells response to UHMWPE, remains unknown. Herein we choose FLS cells as research object. Vimentin (+) CD68 (-) was identified by flow cytometry and immunofluorescent staining assay, and the cells were identified as FLS cells, which was consistent with the experimental requirements. The inhibitory evaluation showed that UHMWPE could significantly promote the proliferation and inhibit apoptosis of FLS cells in dose- and time-dependent manners and increase the levels of proinflammatory cytokines, including IL-6, IL-1β, TNF-α, PGE2, MMP2, and LOX. UHMWPE also can induce the expression of mIL-6R protein in FLS cells and further investigate the relationship between apoptosis and inflammation. Interestingly enough, when we added the interleukin-6 receptor antagonist (IL-6RA), the expression levels of proapoptosis-related proteins increased; in other words, UHMWPE-induced antiapoptosis diminished by IL-6RA (50 μg/ml). Taken together, these findings clearly demonstrated that UHMWPE promote growth in FLS cells through upregulating inflammatory factors to produce antiapoptotic effect.

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“…In RA, multiple proinflammatory molecules are involved, including increased interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6, and IL-17 [15][16][17]. In addition to their well-established actions on immune cells [18], these RA-relevant stimuli result in the molecular activation of catabolic and inflammatory processes in human chondrocytes.…”

Section: Chondrocytes Acting As Target Cells In Ramentioning

confidence: 99%

Dual Role of Chondrocytes in Rheumatoid Arthritis: The Chicken and the Egg

Tseng

Chen

Chang

et al. 2020

IJMS

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Rheumatoid arthritis (RA) is one of the inflammatory joint diseases that display features of articular cartilage destruction. The underlying disturbance results from immune dysregulation that directly and indirectly influence chondrocyte physiology. In the last years, significant evidence inferred from studies in vitro and in the animal model offered a more holistic vision of chondrocytes in RA. Chondrocytes, despite being one of injured cells in RA, also undergo molecular alterations to actively participate in inflammation and matrix destruction in the human rheumatoid joint. This review covers current knowledge about the specific cellular and biochemical mechanisms that account for the chondrocyte signatures of RA and its potential applications for diagnosis and prognosis in RA.

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Vitamin D status in patients with rheumatoid arthritis: a correlation analysis with disease activity and progression, as well as serum IL-6 levels

Cited by 17 publications

References 24 publications

Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

The Role of IL-6RA in UHMWPE Promotes Proliferation in Fibro-Like Synovial Cells

Dual Role of Chondrocytes in Rheumatoid Arthritis: The Chicken and the Egg

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