Vitamin D Status Is Associated With Functional Limitations and Functional Decline in Older Individuals

Sohl, E.; Schoor, Natasja M. van; Jongh, Renate T. de; Visser, Marjolein; Deeg, Dorly J. H.; Lips, Paul

doi:10.1210/jc.2013-1698

Cited by 75 publications

(60 citation statements)

References 32 publications

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“…Vitamin D deficiency or insufficiency hinders muscle strength and physical performance, which can be detrimental to athletic performance in young adults and to activities of daily living in http elderly [13][14][15][16][17][18][19][20][21][22][23]. Although supplemental vitamin D increases serum 25(OH)D, results regarding the influence of supplementation on muscle strength and physical performance are inconsistent [24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study

Barker

Rogers

Levy³

et al. 2015

Cytokine

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Section: Introductionmentioning

confidence: 99%

Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study

Barker

Rogers

Levy³

et al. 2015

Cytokine

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“…A growing literature (1)(2)(3) suggests that vitamin D may be associated with reduced mortality (overall (4) and hospital-associated (5) ), incidence of cancer (6)(7)(8)(9)(10)(11)(12)(13) , CVD (14,15) , diabetes (16) , fractures (17,18) and ageing-related functional limitations (19) , although some studies find an unclear relationship (20,21) or a harmful association with disease (22) . Randomized controlled trials are underway to examine the potential role of vitamin D in the prevention of multiple diseases, including cancer, CVD and diabetes (20,23) .…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in minority populations

Taksler

Cutler

Giovannucci

et al. 2014

Public Health Nutr.

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Objective: Black and Hispanic individuals synthesize less vitamin D per unit of sun exposure than white individuals. The relationship between UV radiation and vitamin D insufficiency in minorities has not been well explored. Design: Prospective cohort study. Setting: Using the National Health and Nutrition Examination Survey, we obtained serum vitamin D levels for non-Hispanic Whites, Hispanics and non-Hispanic Blacks aged ≥18 years from [2000][2001][2002][2003][2004][2005][2006]. We linked these data with the average monthly solar UV index by census tract and data on sun exposure, vitamin D supplementation, health and demographics. We used multivariable regression analyses to assess vitamin D deficiency (<15 ng/ml) and insufficiency (<20 ng/ml) in January (when the UV index was lowest) by race/ethnicity and geography. Subjects: Adults (n 14 319) aged ≥18 years. Results: A 1-point increase in the UV index was associated with a 0·51 ng/ml increase in vitamin D (95 % CI 0·35, 0·67 ng/ml; P < 0·001). Non-Hispanic Black race and Hispanic ethnicity were associated with a 7·47 and 3·41 ng/ml decrease in vitamin D, respectively (both P < 0·001). In January, an estimated 65·4 % of nonHispanic Blacks were deficient in vitamin D, compared with 28·9 % of Hispanics and 14·0 % of non-Hispanic Whites. An estimated 84·2 % of non-Hispanic Blacks were insufficient in vitamin D v. 56·3 % of Hispanics and 34·8 % of non-Hispanic Whites. More non-Hispanic Blacks were estimated to be deficient in vitamin D in January in the highest UV index quartile than were non-Hispanic Whites in the lowest UV index quartile (60·2 % v. 25·7 %). Conclusions: Wintertime vitamin D insufficiency is pervasive among minority populations, and not uncommon among non-Hispanic Whites. KeywordsVitamins Vitamin D Disparities Race SurvivalThe Institute of Medicine estimates that 54 % of non-Hispanic Blacks have very low levels of vitamin D (25-hydroxycholecalifierol (25(OH)D 3 ) < 16 ng/ml), v. 27 % of Mexican Americans and 11 % of non-Hispanic Whites (1,2) . A growing literature (1)(2)(3) suggests that vitamin D may be associated with reduced mortality (overall (4) and hospital-associated (5) ), incidence of cancer (6)(7)(8)(9)(10)(11)(12)(13) , CVD (14,15) , diabetes (16) , fractures (17,18) and ageing-related functional limitations (19) , although some studies find an unclear relationship (20,21) or a harmful association with disease (22) . Randomized controlled trials are underway to examine the potential role of vitamin D in the prevention of multiple diseases, including cancer, CVD and diabetes (20,23) .There are known racial and seasonal variations in vitamin D. Black individuals synthesize less vitamin D per unit of sun exposure than white individuals, because darker complexion acts as a natural sunscreen (24,25) .The majority of vitamin D is estimated to derive from sunshine for most people (26) , with the liver converting cholecalciferol into 25(OH)D 3 , the form of vitamin D typically measured in blood serum. 25(OH)D 3 has a reported half-lif...

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“…Deficiency of this vitamin, along with vitamin C and carotenoids, is associated with cognitive decline in the elderly 33 . Vitamin D, which is important not only in the bone health of the elderly 13 , but also associated with muscle strength, functional capacity 34 and prevention of chronic degenerative diseases 13 , was low in 2/3 of the diets. As the solar exposure of individuals in home ENT is normally impaired due to the bedridden status of most of these elderly people, it is necessary to supplement this vitamin in the 1500 and 1800 Kcal diets.…”

Section: Resultsmentioning

confidence: 99%

Development of enteral homemade diets for elderly persons receiving home care and analysis of macro and micronutrient composition

Jansen

Generoso

Guedes

et al. 2017

Rev. bras. geriatr. gerontol.

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Objective: the development and analysis of the macro and micronutrient composition of homemade enteral diets. Method: A standard homemade enteral diet was developed at three caloric concentrations -1500, 1800 and 2100 Kcal. After preparation and testing of viscosity, stability, odor and color, plus evaluation of cost, the chemical composition of the nutrients of the diets were analytically determined. Folic acid, vitamin D and vitamin B12 values were calculated using chemical composition tables. The results were compared with recommended nutritional standards for the elderly. Result: The diets exhibited normal macronutrient distribution. The 1500 caloric level presented some mineral and vitamin deficiencies. Suitable values were obtained at the other caloric levels for all minerals except magnesium. There were appropriate levels of all the vitamins in the 2100 Kcal diet, while vitamin E, D and B6 levels were below the recommended dietary allowances in the 1800 Kcal diet. Conclusion: The standard homemade enteral diets studied can contribute to the food and nutritional safety of elderly persons undergoing home care, if all are supplemented with magnesium and the 1800 Kcal diet is supplemented with vitamin E, D and B6. The 1500 Kcal diet was not nutritionally safe in terms of micronutrients.

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Vitamin D Status Is Associated With Functional Limitations and Functional Decline in Older Individuals

Cited by 75 publications

References 32 publications

Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study

Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study

Vitamin D deficiency in minority populations

Development of enteral homemade diets for elderly persons receiving home care and analysis of macro and micronutrient composition

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