Vitamin D status is not associated with clinical severity of COVID-19 in pregnant women

Tekin, Arzu Bilge; Yassa, Murat; Birol, Pınar; Unlu, Sakine Nisa; Sahin, Turan; Buran, Ayca Miray; Ayanoğlu, Esra; Tuğ, Niyazi

doi:10.1007/s00394-021-02709-7

Cited by 13 publications

(33 citation statements)

References 28 publications

(46 reference statements)

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“…While we did not recruit any control group of healthy people to assess vitamin D status as a predisposing factor of COVID-19, our data suggested that none of the clinical factors was associated with vitamin D levels. Tekin et al's study found a similar finding of the no association of vitamin D levels with disease severity [19]. In controversy to our results, Vasheghani et al [20], Campi et al [21], and Meltzer et al [22] found a significant relationship between vitamin D and the severity of COVID-19.…”

Section: Discussionsupporting

confidence: 60%

Untitled

2023

J. Med. Chem. Sci.

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Background: Vitamin D linkage with COVID-19 is investigated in many studies, but there is still no single summation. Thus, this study aimed to evaluate the relationship between Vitamin D levels and clinical characteristics of COVID-19. Methods: This was a retrospective cross-sectional study on floor admitted COVID-19 patients in the Jahrom province of Iran in 2020. The patients in this study were divided into different groups based on vitamin D status after the definitive diagnosis of COVID-19. Demographic and clinical characteristics of COVID-19 patients were analyzed based on the COVID-19 status. Results: Vitamin D levels were normal for almost half of the patients (51.7%) and the rest were insufficient (25.9%) or deficient (22.4%). Serum vitamin D levels did not correlate with vital sign data and venous blood gas results (P> 0.05). Vitamin D status was not different among patients with different symptoms of COVID-19 (P> 0.05). Conclusion: Our results revealed that vitamin D levels is not correlated to clinical characteristics in COVID-19 patients. In addition, well-designed studies with a good sample size are required to draw conclusions.

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Section: Discussionsupporting

confidence: 60%

Untitled

2023

J. Med. Chem. Sci.

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“…Additionally, pregnant women with moderate/severe COVID‐19 presented severe vitamin D deficiency (9.06 ng/ml) in comparison with pregnant women with mild COVID‐19 (13.69 ng/ml) 19 . In contrast, in another study, vitamin D levels were not associated with the severity of COVID‐19 during pregnancy, as similar levels of vitamin D deficiency were found in COVID‐19‐negative‐ and COVID‐19‐positive pregnant women 24 …”

Section: Discussionmentioning

confidence: 86%

“… 19 In contrast, in another study, vitamin D levels were not associated with the severity of COVID‐19 during pregnancy, as similar levels of vitamin D deficiency were found in COVID‐19‐negative‐ and COVID‐19‐positive pregnant women. 24 …”

Section: Discussionmentioning

confidence: 99%

Oxidative stress status and vitamin D levels of asymptomatic to mild symptomatic COVID‐19 infections during the third trimester of pregnancy: A retrospective study in Metz, France

Schmitt

Labdouni²,

Soulimani

et al. 2022

Journal of Medical Virology

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It is believed that the subtle equilibrium between tolerance and immunity during the unique biological state of pregnancy, which is characterized by further physiological and hormonal changes, rends pregnant women more vulnerable to coronavirus disease 2019 . In this retrospective study, confirmed COVID-19-positive pregnant women (n = 15) during their third trimester, comprising asymptomatic (n = 7) and mild symptomatic (n = 8), and healthy pregnant controls (n = 20), were

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“…These vitamin D levels were also statistically significantly lower in those women with moderate or severe COVID-19 infection compared to those with milder infection [ 21 ]. However, another cohort study in pregnant women found no statistically significant differences in vitamin D deficiency between pregnant women with COVID-19 infection and control group, nor the severity of infection [ 22 ]. Mean 25(OH)D levels were significantly lower than the cut-off values (30 ng/mL was taken as the cut-off value) in a published study of 44 pregnant women with COVID-19 infection.…”

Section: Discussionmentioning

confidence: 99%

Serum 25(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease 2019 (COVID-19): A Case-Control Study

Ferrer-Sánchez

Díaz-Goicoechea

Mayoral-Cesar

et al. 2022

IJERPH

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The physiological changes during pregnancy may increase the risk of complications in pregnant women with coronavirus disease 2019 (COVID-19). Vitamin D is a fat-soluble secosteroid hormone and its role in immunity is appears to be of particular importance in this recent pandemic. Nevertheless, there is little research about the role of vitamin D levels regarding COVID-19 in pregnant women to date. This study aimed to establish a relationship between serum 25-hydroxyvitamin D (25(OH)D) levels in pregnant women and COVID-19. A comparative case-control study was performed with a study population of 256 pregnant women (82 pregnant women with infection and 174 women in control group). Serum 25(OH)D levels were significantly lower in pregnant women with COVID-19 infection than in those without infection. In addition, 89% of COVID-19-positive pregnant women had 25(OH)D deficiency, while in the control group the percentage was 75.30%, finding statistically significant differences (ORa = 2.68; 95% CI 1.19–6.06; p = 0.01). Our results find a relationship between vitamin D deficiency in pregnant women and COVID-19 infection. This finding could be relevant for actual clinical practice. Thus, more research is needed in this field.

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Vitamin D status is not associated with clinical severity of COVID-19 in pregnant women

Cited by 13 publications

References 28 publications

Untitled

Untitled

Oxidative stress status and vitamin D levels of asymptomatic to mild symptomatic COVID‐19 infections during the third trimester of pregnancy: A retrospective study in Metz, France

Serum 25(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease 2019 (COVID-19): A Case-Control Study

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