Vitamin D Status May Help Explain Racial Disparities in Pancreatic Cancer Incidence and Mortality in the United States

Grant, William B.

doi:10.1016/j.cgh.2019.12.033

Cited by 3 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They include smoking and associated behaviors ( 21 ). and sex-steroid hormones ( 22 ). The factor of remoteness has also been found to explain higher mortality rates ( 23 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

Gender and racial disparities in the incidence and mortality of pancreatic cancer in Mississippi State from 2003 to 2019

Nduma¹,

Ambe²,

Ekhator³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

Background In the United States, the incidence and prevalence of pancreatic cancer are well-established relative to the factors of gender and race. These rates can be seen to be dictated by biological, behavioral, socio-environmental, socioeconomic, and structural factors. This paper focused on the context of Mississippi, with a particular emphasis on racial and gender-linked mortality and incidence from 2003 to 2019. Methods Data were obtained from the Mississippi Cancer Registry. Specific parameters that were focused upon included the data source in the form of all cancer incidents and cancer mortality, geography in terms of cancer coalition regions, cancer sites in the form of the digestive system as a category to which pancreatic cancer belongs, and the year, ranging from 2003 to 2019. Results From the findings, the rates were more dominant in blacks than their white counterparts, suggesting racial disparity. Additionally, regardless of race, females exhibited lower rates compared to males. In the state, there were also marked geographical variations in disease incidence and mortality rates, with the Delta cancer coalition region faring the worst in terms of incidence rates for both races and genders. Conclusions It was concluded that in Mississippi, being a black male poses the highest risk. In the future, certain additional factors that will need to be investigated as per their probable moderating role to inform the coining of health care interventions at the state level. They include lifestyle and behavioral factors, comorbidities, stage of disease, and geographical variations or remoteness.

show abstract

“…They include smoking and associated behaviors ( 21 ). and sex-steroid hormones ( 22 ). The factor of remoteness has also been found to explain higher mortality rates ( 23 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

Gender and racial disparities in the incidence and mortality of pancreatic cancer in Mississippi State from 2003 to 2019

Nduma¹,

Ambe²,

Ekhator³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

show abstract

“…[ 25 ] Although the association of vitamin D level with pancreatic cancer is controversial, studies have been reported linking vitamin D level to pancreatic cancer after comparing differences in vitamin D level between ethnic groups, with evidence that it has an overall effect on incidence and mortality rate. [ 24 , 26 – 29 ]…”

Section: Discussionmentioning

confidence: 99%

Risk of cancer in patients with recurrent aphthous stomatitis in Korea

et al. 2021

View full text Add to dashboard Cite

The relationship between recurrent aphthous stomatitis (RAS), a common mucosal lesion, and cancer has not been demonstrated. This study investigated the risk for developing cancer in patients with RAS, based on data from Korea's National Health Insurance Sharing Service (NHISS). Nationwide population-based cohort data from 2005 to 2009 provided by the NHISS was used. The group diagnosed with RAS for 5 years and an undiagnosed control group were constructed through 1:1 propensity score matching (PSM). The experimental design compared the incidence rate of a cancer diagnosis from 2010 to 2015 between these 2 groups. After identifying 13,808 people that met our inclusion criterion from a 1 million cohort group, 13,808 controls were included in the study through PSM. Among all cancers, pancreatic cancer had an adjusted hazard ratio of 1.26 (95% confidence interval: 1.01–1.57, P < .041). For the rest of the cancers, there was no significant incidence rate. RAS was associated with an increased risk of pancreatic cancer in the analysis using large population-based cohort data. Further long-term follow-up studies are needed.

show abstract